Time-restricted feeding alters isoflurane-induced memory deficits
Food consumption during the rest phase promotes circadian desynchrony, which is corrected with harmful physiological and mental disorders. Previously, we found that circadian desynchrony was involved in isoflurane-induced cognitive impairment. Here, we scheduled food access to modulate daily rhythm...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2020-09-01
|
| Series: | Translational Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tnsci-2020-0130 |
| _version_ | 1797987801471385600 |
|---|---|
| author | Song Jia Chu Shuaishuai Fang Xin Xu Fangxia Zhang Peng Zhao Xin Ma Zhengliang Xia Tianjiao Gu Xiaoping |
| author_facet | Song Jia Chu Shuaishuai Fang Xin Xu Fangxia Zhang Peng Zhao Xin Ma Zhengliang Xia Tianjiao Gu Xiaoping |
| author_sort | Song Jia |
| collection | DOAJ |
| description | Food consumption during the rest phase promotes circadian desynchrony, which is corrected with harmful physiological and mental disorders. Previously, we found that circadian desynchrony was involved in isoflurane-induced cognitive impairment. Here, we scheduled food access to modulate daily rhythm to examine its impact on isoflurane-induced cognitive impairments. Mice were randomly transferred to restricted feeding (RF) time groups: Control group (Zeitgeber time (ZT) 0–ZT24, ad libitum feeding), Day-Feeding group (ZT0–ZT12, misaligned feeding), and Night-Feeding group (ZT12–ZT24, aligned feeding). Then, some of them were subjected to 5 h of 1.3% isoflurane anaesthesia from ZT14 to ZT19 and were divided into the Control + Anes group, the Day-Feeding + Anes group, and the Night-Feeding + Anes group. Mini-Mitter was used to monitor the daily rhythm. Fear conditioning system was conducted to assess cognition of mice. We observed that the Night-Feeding group adapted to RF gradually, whereas the Day-Feeding group exhibited a disturbed daily rhythm. The Night-Feeding + Anes group exhibited a partially enhanced daily rhythm, whereas the Day-Feeding + Anes group exhibited sustained phase advances and diurnality score increase 7 days after isoflurane anaesthesia. Notably, in tests of hippocampus-dependent contextual memory, the Night-Feeding + Anes group demonstrated decreased deficits; the Day-Feeding + Anes group showed prolonged post-anaesthetic deficits 14 days after isoflurane anaesthesia. However, amygdala-dependent cued-fear conditioning post-anaesthesia was not altered by the RF schedule. In conclusion, we demonstrated that misaligned feeding disturbed the daily rhythm and led to persistent post-anaesthetic cognitive dysfunction. Aligned feeding enhanced the daily rhythm partially and improved post-anaesthetic cognitive dysfunction. |
| first_indexed | 2024-04-11T07:52:56Z |
| format | Article |
| id | doaj.art-9364a396548441e3a43afc43a3b05513 |
| institution | Directory Open Access Journal |
| issn | 2081-6936 |
| language | English |
| last_indexed | 2024-04-11T07:52:56Z |
| publishDate | 2020-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj.art-9364a396548441e3a43afc43a3b055132022-12-22T04:36:01ZengDe GruyterTranslational Neuroscience2081-69362020-09-0111134135510.1515/tnsci-2020-0130tnsci-2020-0130Time-restricted feeding alters isoflurane-induced memory deficitsSong Jia0Chu Shuaishuai1Fang Xin2Xu Fangxia3Zhang Peng4Zhao Xin5Ma Zhengliang6Xia Tianjiao7Gu Xiaoping8Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical Department of Nanjing University, 321 Zhong Shan Road, Nanjing, Jiangsu 210008, P. R. ChinaDepartment of Anesthesiology, Affiliated Drum Tower Hospital of Medical Department of Nanjing University, 321 Zhong Shan Road, Nanjing, Jiangsu 210008, P. R. ChinaDepartment of Anesthesiology, Affiliated Drum Tower Hospital of Medical Department of Nanjing University, 321 Zhong Shan Road, Nanjing, Jiangsu 210008, P. R. ChinaDepartment of Anesthesiology, Affiliated Drum Tower Hospital of Medical Department of Nanjing University, 321 Zhong Shan Road, Nanjing, Jiangsu 210008, P. R. ChinaDepartment of Anesthesiology, Affiliated Drum Tower Hospital of Medical Department of Nanjing University, 321 Zhong Shan Road, Nanjing, Jiangsu 210008, P. R. ChinaDepartment of Anesthesiology, Nanjing Stomatological Hospital, Medical School of Nanjing University, No 30 Zhongyang Road, Nanjing, 210008, ChinaDepartment of Anesthesiology, Affiliated Drum Tower Hospital of Medical Department of Nanjing University, 321 Zhong Shan Road, Nanjing, Jiangsu 210008, P. R. ChinaDepartment of Anesthesiology, Affiliated Drum Tower Hospital of Medical Department of Nanjing University, 321 Zhong Shan Road, Nanjing, Jiangsu 210008, P. R. ChinaDepartment of Anesthesiology, Affiliated Drum Tower Hospital of Medical Department of Nanjing University, 321 Zhong Shan Road, Nanjing, Jiangsu 210008, P. R. ChinaFood consumption during the rest phase promotes circadian desynchrony, which is corrected with harmful physiological and mental disorders. Previously, we found that circadian desynchrony was involved in isoflurane-induced cognitive impairment. Here, we scheduled food access to modulate daily rhythm to examine its impact on isoflurane-induced cognitive impairments. Mice were randomly transferred to restricted feeding (RF) time groups: Control group (Zeitgeber time (ZT) 0–ZT24, ad libitum feeding), Day-Feeding group (ZT0–ZT12, misaligned feeding), and Night-Feeding group (ZT12–ZT24, aligned feeding). Then, some of them were subjected to 5 h of 1.3% isoflurane anaesthesia from ZT14 to ZT19 and were divided into the Control + Anes group, the Day-Feeding + Anes group, and the Night-Feeding + Anes group. Mini-Mitter was used to monitor the daily rhythm. Fear conditioning system was conducted to assess cognition of mice. We observed that the Night-Feeding group adapted to RF gradually, whereas the Day-Feeding group exhibited a disturbed daily rhythm. The Night-Feeding + Anes group exhibited a partially enhanced daily rhythm, whereas the Day-Feeding + Anes group exhibited sustained phase advances and diurnality score increase 7 days after isoflurane anaesthesia. Notably, in tests of hippocampus-dependent contextual memory, the Night-Feeding + Anes group demonstrated decreased deficits; the Day-Feeding + Anes group showed prolonged post-anaesthetic deficits 14 days after isoflurane anaesthesia. However, amygdala-dependent cued-fear conditioning post-anaesthesia was not altered by the RF schedule. In conclusion, we demonstrated that misaligned feeding disturbed the daily rhythm and led to persistent post-anaesthetic cognitive dysfunction. Aligned feeding enhanced the daily rhythm partially and improved post-anaesthetic cognitive dysfunction.https://doi.org/10.1515/tnsci-2020-0130aligned/misaligned feedingdaily rhythmcognition dysfunctionisoflurane |
| spellingShingle | Song Jia Chu Shuaishuai Fang Xin Xu Fangxia Zhang Peng Zhao Xin Ma Zhengliang Xia Tianjiao Gu Xiaoping Time-restricted feeding alters isoflurane-induced memory deficits Translational Neuroscience aligned/misaligned feeding daily rhythm cognition dysfunction isoflurane |
| title | Time-restricted feeding alters isoflurane-induced memory deficits |
| title_full | Time-restricted feeding alters isoflurane-induced memory deficits |
| title_fullStr | Time-restricted feeding alters isoflurane-induced memory deficits |
| title_full_unstemmed | Time-restricted feeding alters isoflurane-induced memory deficits |
| title_short | Time-restricted feeding alters isoflurane-induced memory deficits |
| title_sort | time restricted feeding alters isoflurane induced memory deficits |
| topic | aligned/misaligned feeding daily rhythm cognition dysfunction isoflurane |
| url | https://doi.org/10.1515/tnsci-2020-0130 |
| work_keys_str_mv | AT songjia timerestrictedfeedingaltersisofluraneinducedmemorydeficits AT chushuaishuai timerestrictedfeedingaltersisofluraneinducedmemorydeficits AT fangxin timerestrictedfeedingaltersisofluraneinducedmemorydeficits AT xufangxia timerestrictedfeedingaltersisofluraneinducedmemorydeficits AT zhangpeng timerestrictedfeedingaltersisofluraneinducedmemorydeficits AT zhaoxin timerestrictedfeedingaltersisofluraneinducedmemorydeficits AT mazhengliang timerestrictedfeedingaltersisofluraneinducedmemorydeficits AT xiatianjiao timerestrictedfeedingaltersisofluraneinducedmemorydeficits AT guxiaoping timerestrictedfeedingaltersisofluraneinducedmemorydeficits |