Slower Titration of Liraglutide Achieves better Tolerability in some Patients
ABSTRACT: Objective: Liraglutide, when titrated according to the package insert, has a 20% incidence of nausea. More recently, liraglutide was studied in combination with insulin degludec. The titration schedule for the combination injection is considerably slower than that recommended for liragluti...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | AACE Clinical Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2376060520304491 |
| _version_ | 1818414144516259840 |
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| author | Martin M. Grajower, MD, FACP, FACE |
| author_facet | Martin M. Grajower, MD, FACP, FACE |
| author_sort | Martin M. Grajower, MD, FACP, FACE |
| collection | DOAJ |
| description | ABSTRACT: Objective: Liraglutide, when titrated according to the package insert, has a 20% incidence of nausea. More recently, liraglutide was studied in combination with insulin degludec. The titration schedule for the combination injection is considerably slower than that recommended for liraglutide alone, and has only a 9% incidence of nausea.Methods: A slower titration of liraglutide was administered to 3 patients who were unable to tolerate a higher dose due to nausea.Results: In all 3 patients, the slower titration allowed them to ultimately tolerate the higher dose.Conclusion: Slower titration of liraglutide may improve tolerability and should be considered as an “off-label” means of achieving slower, but improved, tolerability for this drug in some patients. A larger study looking at different titration schedules to see which achieves optimal tolerability in the shortest amount of time should be encouraged. |
| first_indexed | 2024-12-14T11:14:26Z |
| format | Article |
| id | doaj.art-936510406bf1426b8c47f49ed85c7be2 |
| institution | Directory Open Access Journal |
| issn | 2376-0605 |
| language | English |
| last_indexed | 2024-12-14T11:14:26Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AACE Clinical Case Reports |
| spelling | doaj.art-936510406bf1426b8c47f49ed85c7be22022-12-21T23:04:06ZengElsevierAACE Clinical Case Reports2376-06052018-01-014178Slower Titration of Liraglutide Achieves better Tolerability in some PatientsMartin M. Grajower, MD, FACP, FACE0From Division of Endocrinology, Albert Einstein College of Medicine, Bronx, New York.; Address correspondence to Dr. Martin M. Grajower, Division of Endocrinology, Albert Einstein College of Medicine, 3736 Henry Hudson Parkway, Bronx, NY 10463.ABSTRACT: Objective: Liraglutide, when titrated according to the package insert, has a 20% incidence of nausea. More recently, liraglutide was studied in combination with insulin degludec. The titration schedule for the combination injection is considerably slower than that recommended for liraglutide alone, and has only a 9% incidence of nausea.Methods: A slower titration of liraglutide was administered to 3 patients who were unable to tolerate a higher dose due to nausea.Results: In all 3 patients, the slower titration allowed them to ultimately tolerate the higher dose.Conclusion: Slower titration of liraglutide may improve tolerability and should be considered as an “off-label” means of achieving slower, but improved, tolerability for this drug in some patients. A larger study looking at different titration schedules to see which achieves optimal tolerability in the shortest amount of time should be encouraged.http://www.sciencedirect.com/science/article/pii/S2376060520304491 |
| spellingShingle | Martin M. Grajower, MD, FACP, FACE Slower Titration of Liraglutide Achieves better Tolerability in some Patients AACE Clinical Case Reports |
| title | Slower Titration of Liraglutide Achieves better Tolerability in some Patients |
| title_full | Slower Titration of Liraglutide Achieves better Tolerability in some Patients |
| title_fullStr | Slower Titration of Liraglutide Achieves better Tolerability in some Patients |
| title_full_unstemmed | Slower Titration of Liraglutide Achieves better Tolerability in some Patients |
| title_short | Slower Titration of Liraglutide Achieves better Tolerability in some Patients |
| title_sort | slower titration of liraglutide achieves better tolerability in some patients |
| url | http://www.sciencedirect.com/science/article/pii/S2376060520304491 |
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