Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain
Central integration of peripheral appetite-regulating signals ensures maintenance of energy homeostasis. Thus, plasticity of circulating molecule access to neuronal circuits involved in feeding behavior plays a key role in the adaptive response to metabolic changes. However, the mechanisms involved...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical investigation
2023-02-01
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| Series: | JCI Insight |
| Subjects: | |
| Online Access: | https://doi.org/10.1172/jci.insight.165763 |
| _version_ | 1797634376582823936 |
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| author | Nicola Romanò Chrystel Lafont Pauline Campos Anne Guillou Tatiana Fiordelisio David J. Hodson Patrice Mollard Marie Schaeffer |
| author_facet | Nicola Romanò Chrystel Lafont Pauline Campos Anne Guillou Tatiana Fiordelisio David J. Hodson Patrice Mollard Marie Schaeffer |
| author_sort | Nicola Romanò |
| collection | DOAJ |
| description | Central integration of peripheral appetite-regulating signals ensures maintenance of energy homeostasis. Thus, plasticity of circulating molecule access to neuronal circuits involved in feeding behavior plays a key role in the adaptive response to metabolic changes. However, the mechanisms involved remain poorly understood despite their relevance for therapeutic development. Here, we investigated the role of median eminence mural cells, including smooth muscle cells and pericytes, in modulating gut hormone effects on orexigenic/anorexigenic circuits. We found that conditional activation of median eminence vascular cells impinged on local blood flow velocity and altered ghrelin-stimulated food intake by delaying ghrelin access to target neurons. Thus, activation of median eminence vascular cells modulates food intake in response to peripheral ghrelin by reducing local blood flow velocity and access to the metabolic brain. |
| first_indexed | 2024-03-11T12:06:48Z |
| format | Article |
| id | doaj.art-9366357e78f9456aafa1ebc66f4c08d6 |
| institution | Directory Open Access Journal |
| issn | 2379-3708 |
| language | English |
| last_indexed | 2024-03-11T12:06:48Z |
| publishDate | 2023-02-01 |
| publisher | American Society for Clinical investigation |
| record_format | Article |
| series | JCI Insight |
| spelling | doaj.art-9366357e78f9456aafa1ebc66f4c08d62023-11-07T16:25:10ZengAmerican Society for Clinical investigationJCI Insight2379-37082023-02-0183Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brainNicola RomanòChrystel LafontPauline CamposAnne GuillouTatiana FiordelisioDavid J. HodsonPatrice MollardMarie SchaefferCentral integration of peripheral appetite-regulating signals ensures maintenance of energy homeostasis. Thus, plasticity of circulating molecule access to neuronal circuits involved in feeding behavior plays a key role in the adaptive response to metabolic changes. However, the mechanisms involved remain poorly understood despite their relevance for therapeutic development. Here, we investigated the role of median eminence mural cells, including smooth muscle cells and pericytes, in modulating gut hormone effects on orexigenic/anorexigenic circuits. We found that conditional activation of median eminence vascular cells impinged on local blood flow velocity and altered ghrelin-stimulated food intake by delaying ghrelin access to target neurons. Thus, activation of median eminence vascular cells modulates food intake in response to peripheral ghrelin by reducing local blood flow velocity and access to the metabolic brain.https://doi.org/10.1172/jci.insight.165763Metabolism |
| spellingShingle | Nicola Romanò Chrystel Lafont Pauline Campos Anne Guillou Tatiana Fiordelisio David J. Hodson Patrice Mollard Marie Schaeffer Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain JCI Insight Metabolism |
| title | Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain |
| title_full | Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain |
| title_fullStr | Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain |
| title_full_unstemmed | Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain |
| title_short | Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain |
| title_sort | median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain |
| topic | Metabolism |
| url | https://doi.org/10.1172/jci.insight.165763 |
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