Copy Number Alterations of Depressed Colorectal Neoplasm Predict the Survival and Response to Oxaliplatin in Proximal Colon Cancer
Depressed colorectal neoplasm exhibits high malignant potential and shows rapid invasiveness. We investigated the genomic profile of depressed neoplasms and clarified the survival outcome and treatment response of the cancers arising from them. We examined 20 depressed and 13 polypoid neoplasms by g...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/6/1527 |
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| author | Li-Chun Chang Han-Mo Chiu Bing-Ching Ho Min-Hsuan Chen Yin-Chen Hsu Wei-Tzu Chiu Kang-Yi Su Chia-Tung Shun Jin-Tung Liang Sung-Liang Yu Ming-Shiang Wu |
| author_facet | Li-Chun Chang Han-Mo Chiu Bing-Ching Ho Min-Hsuan Chen Yin-Chen Hsu Wei-Tzu Chiu Kang-Yi Su Chia-Tung Shun Jin-Tung Liang Sung-Liang Yu Ming-Shiang Wu |
| author_sort | Li-Chun Chang |
| collection | DOAJ |
| description | Depressed colorectal neoplasm exhibits high malignant potential and shows rapid invasiveness. We investigated the genomic profile of depressed neoplasms and clarified the survival outcome and treatment response of the cancers arising from them. We examined 20 depressed and 13 polypoid neoplasms by genome-wide copy number analysis. Subsequently, we validated the identified copy number alterations (CNAs) in an independent cohort of 37 depressed and 42 polypoid neoplasms. Finally, the CNAs were tested as biomarkers in 530 colorectal cancers (CRCs) to clarify the clinical outcome of depressed neoplasms. CNAs in <i>MYC</i>, <i>CCNA1</i>, and <i>BIRC7</i> were significantly enriched in depressed neoplasms and designated as the D-marker panel. CRCs with a D-marker panel have significantly shorter progression-free survival compared with those without (<i>p</i> = 0.012), especially in stage I (<i>p</i> = 0.049), stages T<sub>1+2</sub> (<i>p</i> = 0.027), and proximal cancers (<i>p</i> = 0.002). The positivity of the D-marker panel was an independent risk factor of cancer progression (hazard ratio (95% confidence interval) = 1.52 (1.09–2.11)). Furthermore, the proximal CRCs with D-marker panels had worse overall and progression-free survival when taking oxaliplatin as chemotherapy than those that did not. The D-marker panel may help to optimize treatment and surveillance in proximal CRC and develop a molecular test. However, the current result remains preliminary, and further validation in prospective trials is warranted in the future. |
| first_indexed | 2024-03-10T19:15:13Z |
| format | Article |
| id | doaj.art-9366b9e92b8e44eeb27b27d2ed54d731 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:15:13Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9366b9e92b8e44eeb27b27d2ed54d7312023-11-20T03:27:55ZengMDPI AGCancers2072-66942020-06-01126152710.3390/cancers12061527Copy Number Alterations of Depressed Colorectal Neoplasm Predict the Survival and Response to Oxaliplatin in Proximal Colon CancerLi-Chun Chang0Han-Mo Chiu1Bing-Ching Ho2Min-Hsuan Chen3Yin-Chen Hsu4Wei-Tzu Chiu5Kang-Yi Su6Chia-Tung Shun7Jin-Tung Liang8Sung-Liang Yu9Ming-Shiang Wu10Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, TaiwanCenters of Genomic and Precision Medicine, National Taiwan University, Taipei 100, TaiwanCenters of Genomic and Precision Medicine, National Taiwan University, Taipei 100, TaiwanDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 100, TaiwanDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 100, TaiwanDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 100, TaiwanDepartment of Pathology and Forensic Medicine, National Taiwan University Hospital, Taipei 100, TaiwanDepartment of Surgery, National Taiwan University Hospital, Taipei 100, TaiwanGraduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, TaiwanDepressed colorectal neoplasm exhibits high malignant potential and shows rapid invasiveness. We investigated the genomic profile of depressed neoplasms and clarified the survival outcome and treatment response of the cancers arising from them. We examined 20 depressed and 13 polypoid neoplasms by genome-wide copy number analysis. Subsequently, we validated the identified copy number alterations (CNAs) in an independent cohort of 37 depressed and 42 polypoid neoplasms. Finally, the CNAs were tested as biomarkers in 530 colorectal cancers (CRCs) to clarify the clinical outcome of depressed neoplasms. CNAs in <i>MYC</i>, <i>CCNA1</i>, and <i>BIRC7</i> were significantly enriched in depressed neoplasms and designated as the D-marker panel. CRCs with a D-marker panel have significantly shorter progression-free survival compared with those without (<i>p</i> = 0.012), especially in stage I (<i>p</i> = 0.049), stages T<sub>1+2</sub> (<i>p</i> = 0.027), and proximal cancers (<i>p</i> = 0.002). The positivity of the D-marker panel was an independent risk factor of cancer progression (hazard ratio (95% confidence interval) = 1.52 (1.09–2.11)). Furthermore, the proximal CRCs with D-marker panels had worse overall and progression-free survival when taking oxaliplatin as chemotherapy than those that did not. The D-marker panel may help to optimize treatment and surveillance in proximal CRC and develop a molecular test. However, the current result remains preliminary, and further validation in prospective trials is warranted in the future.https://www.mdpi.com/2072-6694/12/6/1527colorectal cancerCNAschemotherapy<i>MYC</i><i>CCNA1</i><i>BIRC7</i> |
| spellingShingle | Li-Chun Chang Han-Mo Chiu Bing-Ching Ho Min-Hsuan Chen Yin-Chen Hsu Wei-Tzu Chiu Kang-Yi Su Chia-Tung Shun Jin-Tung Liang Sung-Liang Yu Ming-Shiang Wu Copy Number Alterations of Depressed Colorectal Neoplasm Predict the Survival and Response to Oxaliplatin in Proximal Colon Cancer Cancers colorectal cancer CNAs chemotherapy <i>MYC</i> <i>CCNA1</i> <i>BIRC7</i> |
| title | Copy Number Alterations of Depressed Colorectal Neoplasm Predict the Survival and Response to Oxaliplatin in Proximal Colon Cancer |
| title_full | Copy Number Alterations of Depressed Colorectal Neoplasm Predict the Survival and Response to Oxaliplatin in Proximal Colon Cancer |
| title_fullStr | Copy Number Alterations of Depressed Colorectal Neoplasm Predict the Survival and Response to Oxaliplatin in Proximal Colon Cancer |
| title_full_unstemmed | Copy Number Alterations of Depressed Colorectal Neoplasm Predict the Survival and Response to Oxaliplatin in Proximal Colon Cancer |
| title_short | Copy Number Alterations of Depressed Colorectal Neoplasm Predict the Survival and Response to Oxaliplatin in Proximal Colon Cancer |
| title_sort | copy number alterations of depressed colorectal neoplasm predict the survival and response to oxaliplatin in proximal colon cancer |
| topic | colorectal cancer CNAs chemotherapy <i>MYC</i> <i>CCNA1</i> <i>BIRC7</i> |
| url | https://www.mdpi.com/2072-6694/12/6/1527 |
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