Efficacy and safety of respiratory syncytial virus vaccination during pregnancy to prevent lower respiratory tract illness in newborns and infants: a systematic review and meta-analysis of randomized controlled trials
To evaluate the effectiveness and safety of respiratory syncytial virus (RSV) vaccination during pregnancy in preventing lower respiratory tract infection (LRTI) in infants and neonates, we conducted a systematic search of randomized controlled trials (RCTs) in five databases (PubMed, Embase and Coc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1260740/full |
| _version_ | 1827368419415031808 |
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| author | Juan Ma Juan Ma Juan Ma Juan Ma Long Chen ShiFang Tang Yuan Shi Yuan Shi Yuan Shi |
| author_facet | Juan Ma Juan Ma Juan Ma Juan Ma Long Chen ShiFang Tang Yuan Shi Yuan Shi Yuan Shi |
| author_sort | Juan Ma |
| collection | DOAJ |
| description | To evaluate the effectiveness and safety of respiratory syncytial virus (RSV) vaccination during pregnancy in preventing lower respiratory tract infection (LRTI) in infants and neonates, we conducted a systematic search of randomized controlled trials (RCTs) in five databases (PubMed, Embase and Cochrane Library, Web of Science, Cochrane Center Register of Controlled trial) until 1 May 2023. We performed a meta-analysis of the eligible trials using RevMan5.4.1 software. Our analysis included six articles and five RCTs. The meta-analysis revealed significant differences in the incidences of LRTI [risk ratio (RR): 0.64; 95% confidence interval (CI): 0.43, 0.96; p = 0.03)] and severe LRTI (RR: 0.37; 95% CI: 0.18, 0.79; p = 0.01) between the vaccine group and the placebo group for newborns and infants. These differences were observed at 90, 120, and 150 days after birth (p = 0.003, p = 0.05, p = 0.02, p = 0.03, p = 0.009, p = 0.05). At 180 days after birth, there was a significant difference observed in the incidence of LRTI between the two groups (RR: 0.43; 95% CI: 0.21, 0.90; p = 0.02). The safety results showed a significant difference in the incidence of common adverse events between the two groups (RR: 1.08; 95% CI: 1.04, 1.12; p < 0.0001). However, there was no significant difference observed in the incidence of serious adverse events (RR: 1.05; 95% CI: 0.97, 1.15; p = 0.23), common and serious adverse events (RR: 1.02; 95% CI: 0.96, 1.10; p = 0.23), or common and serious adverse events among pregnant women and newborns and infants (RR: 0.98; 95% CI: 0.93, 1.04; p = 0.52). In conclusion, maternal RSV vaccination is an effective and safe immunization strategy for preventing LRTI in postpartum infants, with greater efficacy observed within the first 150 days after birth. |
| first_indexed | 2024-03-08T09:31:08Z |
| format | Article |
| id | doaj.art-9368749db9c7413295af5e32fdf15744 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-08T09:31:08Z |
| publishDate | 2024-01-01 |
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| series | Frontiers in Pediatrics |
| spelling | doaj.art-9368749db9c7413295af5e32fdf157442024-01-31T04:28:40ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-01-011110.3389/fped.2023.12607401260740Efficacy and safety of respiratory syncytial virus vaccination during pregnancy to prevent lower respiratory tract illness in newborns and infants: a systematic review and meta-analysis of randomized controlled trialsJuan Ma0Juan Ma1Juan Ma2Juan Ma3Long Chen4ShiFang Tang5Yuan Shi6Yuan Shi7Yuan Shi8Department of Neonatology, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaChina International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, ChinaDepartment of Neonatology, SongShan General Hospital, Chongqing, ChinaDepartment of Neonatology, Women and Children’s Hospital of Chongqing Medical University (Chongqing Health Center for Women and Children), Chongqing, ChinaDepartment of Neonatology, SongShan General Hospital, Chongqing, ChinaDepartment of Neonatology, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaChina International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, ChinaTo evaluate the effectiveness and safety of respiratory syncytial virus (RSV) vaccination during pregnancy in preventing lower respiratory tract infection (LRTI) in infants and neonates, we conducted a systematic search of randomized controlled trials (RCTs) in five databases (PubMed, Embase and Cochrane Library, Web of Science, Cochrane Center Register of Controlled trial) until 1 May 2023. We performed a meta-analysis of the eligible trials using RevMan5.4.1 software. Our analysis included six articles and five RCTs. The meta-analysis revealed significant differences in the incidences of LRTI [risk ratio (RR): 0.64; 95% confidence interval (CI): 0.43, 0.96; p = 0.03)] and severe LRTI (RR: 0.37; 95% CI: 0.18, 0.79; p = 0.01) between the vaccine group and the placebo group for newborns and infants. These differences were observed at 90, 120, and 150 days after birth (p = 0.003, p = 0.05, p = 0.02, p = 0.03, p = 0.009, p = 0.05). At 180 days after birth, there was a significant difference observed in the incidence of LRTI between the two groups (RR: 0.43; 95% CI: 0.21, 0.90; p = 0.02). The safety results showed a significant difference in the incidence of common adverse events between the two groups (RR: 1.08; 95% CI: 1.04, 1.12; p < 0.0001). However, there was no significant difference observed in the incidence of serious adverse events (RR: 1.05; 95% CI: 0.97, 1.15; p = 0.23), common and serious adverse events (RR: 1.02; 95% CI: 0.96, 1.10; p = 0.23), or common and serious adverse events among pregnant women and newborns and infants (RR: 0.98; 95% CI: 0.93, 1.04; p = 0.52). In conclusion, maternal RSV vaccination is an effective and safe immunization strategy for preventing LRTI in postpartum infants, with greater efficacy observed within the first 150 days after birth.https://www.frontiersin.org/articles/10.3389/fped.2023.1260740/fullrespiratory syncytial virusvaccinationpregnancynewborns and infantsefficiencymeta-analysis |
| spellingShingle | Juan Ma Juan Ma Juan Ma Juan Ma Long Chen ShiFang Tang Yuan Shi Yuan Shi Yuan Shi Efficacy and safety of respiratory syncytial virus vaccination during pregnancy to prevent lower respiratory tract illness in newborns and infants: a systematic review and meta-analysis of randomized controlled trials Frontiers in Pediatrics respiratory syncytial virus vaccination pregnancy newborns and infants efficiency meta-analysis |
| title | Efficacy and safety of respiratory syncytial virus vaccination during pregnancy to prevent lower respiratory tract illness in newborns and infants: a systematic review and meta-analysis of randomized controlled trials |
| title_full | Efficacy and safety of respiratory syncytial virus vaccination during pregnancy to prevent lower respiratory tract illness in newborns and infants: a systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Efficacy and safety of respiratory syncytial virus vaccination during pregnancy to prevent lower respiratory tract illness in newborns and infants: a systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Efficacy and safety of respiratory syncytial virus vaccination during pregnancy to prevent lower respiratory tract illness in newborns and infants: a systematic review and meta-analysis of randomized controlled trials |
| title_short | Efficacy and safety of respiratory syncytial virus vaccination during pregnancy to prevent lower respiratory tract illness in newborns and infants: a systematic review and meta-analysis of randomized controlled trials |
| title_sort | efficacy and safety of respiratory syncytial virus vaccination during pregnancy to prevent lower respiratory tract illness in newborns and infants a systematic review and meta analysis of randomized controlled trials |
| topic | respiratory syncytial virus vaccination pregnancy newborns and infants efficiency meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1260740/full |
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