Soluble Guanylyl Cyclase Activators—Promising Therapeutic Option in the Pharmacotherapy of Heart Failure and Pulmonary Hypertension

Soluble Guanylyl Cyclase Activators—Promising Therapeutic Option in the Pharmacotherapy of Heart Failure and Pulmonary Hypertension

Endogenous nitric oxide (NO)-dependent vascular relaxation plays a leading role in the homeostasis of the cardiovascular, pulmonary, and vascular systems and organs, such as the kidneys, brain, and liver. The mechanism of the intracellular action of NO in blood vessels involves the stimulation of th...

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Bibliographic Details
Main Authors: Grzegorz Grześk, Adrianna Witczyńska, Magdalena Węglarz, Łukasz Wołowiec, Jacek Nowaczyk, Elżbieta Grześk, Alicja Nowaczyk
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
guanylate cyclase (GC)
chronic heart failure (CHF)
pulmonary arterial hypertension (PAH)
vericiguat
riociguat
Online Access:https://www.mdpi.com/1420-3049/28/2/861

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