The expression profile of miR-23b is not altered in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies [v1; ref status: indexed, http://f1000r.es/20z]
Idiopathic inflammatory myopathies (IIM) belong to a group of autoimmune disorders, primarily characterized by chronic inflammation of human skeletal muscle tissue. The etiology of these diseases is unknown, however, genetic predisposition plays a significant role in disease onset. Beside the known...
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F1000 Research Ltd
2013-10-01
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| Online Access: | http://f1000research.com/articles/2-223/v1 |
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| author | Martina Remakova Tana Svitalkova Marek Skoda Jiri Vencovsky Peter Novota |
| author_facet | Martina Remakova Tana Svitalkova Marek Skoda Jiri Vencovsky Peter Novota |
| author_sort | Martina Remakova |
| collection | DOAJ |
| description | Idiopathic inflammatory myopathies (IIM) belong to a group of autoimmune disorders, primarily characterized by chronic inflammation of human skeletal muscle tissue. The etiology of these diseases is unknown, however, genetic predisposition plays a significant role in disease onset. Beside the known genetic risk located in the MHC complex, the epigenetic modifications including changes in miRNAs expression profiles have been recently implicated recently in many autoimmune diseases. Micro RNA molecules are involved in many physiological processes, including the regulation of the immune response. In our study we have focused on the miR-23b, as it represents a novel promising autoimmunity regulator molecule. Downregulation of miR-23b was recently described in patients with rheumatoid arthritis and systemic lupus erythematosus. We have measured the expression miR-23b peripheral blood mononuclear cells of patients with dermatomyositis and polymyositis. No meaningful difference was found in comparison with healthy controls. |
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| id | doaj.art-9369f1b6adf344999b2de4e8512f4e66 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-20T07:25:38Z |
| publishDate | 2013-10-01 |
| publisher | F1000 Research Ltd |
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| spelling | doaj.art-9369f1b6adf344999b2de4e8512f4e662022-12-21T19:48:33ZengF1000 Research LtdF1000Research2046-14022013-10-01210.12688/f1000research.2-223.v12627The expression profile of miR-23b is not altered in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies [v1; ref status: indexed, http://f1000r.es/20z]Martina Remakova0Tana Svitalkova1Marek Skoda2Jiri Vencovsky3Peter Novota4Department of Rheumatology, First Faculty of Medicine, Charles University in Prague and Rheumatology Institute, Prague, Czech RepublicDepartment of Experimental and Clinical Rheumatology, Institute of Rheumatology, Prague, Czech RepublicDepartment of Experimental and Clinical Rheumatology, Institute of Rheumatology, Prague, Czech RepublicDepartment of Experimental and Clinical Rheumatology, Institute of Rheumatology, Prague, Czech RepublicDepartment of Experimental and Clinical Rheumatology, Institute of Rheumatology, Prague, Czech RepublicIdiopathic inflammatory myopathies (IIM) belong to a group of autoimmune disorders, primarily characterized by chronic inflammation of human skeletal muscle tissue. The etiology of these diseases is unknown, however, genetic predisposition plays a significant role in disease onset. Beside the known genetic risk located in the MHC complex, the epigenetic modifications including changes in miRNAs expression profiles have been recently implicated recently in many autoimmune diseases. Micro RNA molecules are involved in many physiological processes, including the regulation of the immune response. In our study we have focused on the miR-23b, as it represents a novel promising autoimmunity regulator molecule. Downregulation of miR-23b was recently described in patients with rheumatoid arthritis and systemic lupus erythematosus. We have measured the expression miR-23b peripheral blood mononuclear cells of patients with dermatomyositis and polymyositis. No meaningful difference was found in comparison with healthy controls.http://f1000research.com/articles/2-223/v1Immune & Inflammatory Rheumatic Diseases (incl. Arthritis)Immunological Biomarkers |
| spellingShingle | Martina Remakova Tana Svitalkova Marek Skoda Jiri Vencovsky Peter Novota The expression profile of miR-23b is not altered in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies [v1; ref status: indexed, http://f1000r.es/20z] F1000Research Immune & Inflammatory Rheumatic Diseases (incl. Arthritis) Immunological Biomarkers |
| title | The expression profile of miR-23b is not altered in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies [v1; ref status: indexed, http://f1000r.es/20z] |
| title_full | The expression profile of miR-23b is not altered in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies [v1; ref status: indexed, http://f1000r.es/20z] |
| title_fullStr | The expression profile of miR-23b is not altered in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies [v1; ref status: indexed, http://f1000r.es/20z] |
| title_full_unstemmed | The expression profile of miR-23b is not altered in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies [v1; ref status: indexed, http://f1000r.es/20z] |
| title_short | The expression profile of miR-23b is not altered in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies [v1; ref status: indexed, http://f1000r.es/20z] |
| title_sort | expression profile of mir 23b is not altered in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies v1 ref status indexed http f1000r es 20z |
| topic | Immune & Inflammatory Rheumatic Diseases (incl. Arthritis) Immunological Biomarkers |
| url | http://f1000research.com/articles/2-223/v1 |
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