An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironmentResearch in context
Summary: Background: Dietary restriction (DR), a general term for dieting, has been demonstrated as an effective intervention in reducing the occurrence of cancers. Molecular activities associated with DR are crucial in mediating its anti-cancer effects, yet a comprehensive exploration of the lands...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396424001130 |
| _version_ | 1827287942996951040 |
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| author | Xiaoyi Song Jiaxing Wei Yang Li Wen Zhu Zhiyuan Cai Kunwei Li Jingyue Wei Jieyu Lu Wanping Pan Man Li |
| author_facet | Xiaoyi Song Jiaxing Wei Yang Li Wen Zhu Zhiyuan Cai Kunwei Li Jingyue Wei Jieyu Lu Wanping Pan Man Li |
| author_sort | Xiaoyi Song |
| collection | DOAJ |
| description | Summary: Background: Dietary restriction (DR), a general term for dieting, has been demonstrated as an effective intervention in reducing the occurrence of cancers. Molecular activities associated with DR are crucial in mediating its anti-cancer effects, yet a comprehensive exploration of the landscape of these activities at the pan-cancer level is still lacking. Methods: We proposed a computational approach for quantifying DR-related molecular activities and delineating the landscape of these activities across 33 cancer types and 30 normal tissues within 27,320 samples. We thoroughly examined the associations between DR-related molecular activities and various factors, including the tumour microenvironment, immunological phenotypes, genomic features, and clinical prognosis. Meanwhile, we identified two DR genes that show potential as prognostic predictors in hepatocellular carcinoma and verified them by immunohistochemical assays in 90 patients. Findings: We found that DR-related molecular activities showed a close association with tumour immunity and hold potential for predicting immunotherapy responses in various cancers. Importantly, a higher level of DR-related molecular activities is associated with improved overall survival and cancer-specific survival. FZD1 and G6PD are two DR genes that serve as biomarkers for predicting the prognosis of patients with hepatocellular carcinoma. Interpretation: This study presents a robust link between DR-related molecular activities and tumour immunity across multiple cancer types. Our research could open the path for further investigation of DR-related molecular processes in cancer treatment. Funding: National Natural Science Foundation of China (Grant No. 82000628) and the Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine Foundation of Guangdong Province (Grant No. 2023LSYS001). |
| first_indexed | 2024-04-24T11:21:36Z |
| format | Article |
| id | doaj.art-936a35c750f34e8ba22ff4a5a34c645f |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-04-24T11:21:36Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-936a35c750f34e8ba22ff4a5a34c645f2024-04-11T04:41:29ZengElsevierEBioMedicine2352-39642024-04-01102105078An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironmentResearch in contextXiaoyi Song0Jiaxing Wei1Yang Li2Wen Zhu3Zhiyuan Cai4Kunwei Li5Jingyue Wei6Jieyu Lu7Wanping Pan8Man Li9Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, ChinaGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, ChinaGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, ChinaGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, ChinaGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, ChinaDepartment of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, ChinaGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, ChinaGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, ChinaGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, ChinaGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Biobank, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Department of Information Technology and Data Center, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China; Corresponding author. Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, 519000, China.Summary: Background: Dietary restriction (DR), a general term for dieting, has been demonstrated as an effective intervention in reducing the occurrence of cancers. Molecular activities associated with DR are crucial in mediating its anti-cancer effects, yet a comprehensive exploration of the landscape of these activities at the pan-cancer level is still lacking. Methods: We proposed a computational approach for quantifying DR-related molecular activities and delineating the landscape of these activities across 33 cancer types and 30 normal tissues within 27,320 samples. We thoroughly examined the associations between DR-related molecular activities and various factors, including the tumour microenvironment, immunological phenotypes, genomic features, and clinical prognosis. Meanwhile, we identified two DR genes that show potential as prognostic predictors in hepatocellular carcinoma and verified them by immunohistochemical assays in 90 patients. Findings: We found that DR-related molecular activities showed a close association with tumour immunity and hold potential for predicting immunotherapy responses in various cancers. Importantly, a higher level of DR-related molecular activities is associated with improved overall survival and cancer-specific survival. FZD1 and G6PD are two DR genes that serve as biomarkers for predicting the prognosis of patients with hepatocellular carcinoma. Interpretation: This study presents a robust link between DR-related molecular activities and tumour immunity across multiple cancer types. Our research could open the path for further investigation of DR-related molecular processes in cancer treatment. Funding: National Natural Science Foundation of China (Grant No. 82000628) and the Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine Foundation of Guangdong Province (Grant No. 2023LSYS001).http://www.sciencedirect.com/science/article/pii/S2352396424001130Caloric restrictionDietary restrictionPan-cancerSingle-cell transcriptomeImmunotherapy |
| spellingShingle | Xiaoyi Song Jiaxing Wei Yang Li Wen Zhu Zhiyuan Cai Kunwei Li Jingyue Wei Jieyu Lu Wanping Pan Man Li An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironmentResearch in context EBioMedicine Caloric restriction Dietary restriction Pan-cancer Single-cell transcriptome Immunotherapy |
| title | An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironmentResearch in context |
| title_full | An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironmentResearch in context |
| title_fullStr | An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironmentResearch in context |
| title_full_unstemmed | An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironmentResearch in context |
| title_short | An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironmentResearch in context |
| title_sort | integrative pan cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironmentresearch in context |
| topic | Caloric restriction Dietary restriction Pan-cancer Single-cell transcriptome Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2352396424001130 |
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