Molecular Epidemiological Characteristics and Risk Factors for Acquiring HBV Among Li Ethnic in Baisha County, Hainan Island-Subgenotype D3 Was First Discovered in China
The residents of Baisha, a county of Hainan Island, mainly composed of Li ethnic population and relatively closed living environment with its unique geographical location. Our previous study showed that Li ethnic population of Baisha is an endemic center for hepatitis C virus, with significantly hig...
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.837746/full |
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| author | Ru Xu Ru Xu Dandan Song Min Wang Min Wang Jieting Huang Jieting Huang Qiao Liao Qiao Liao Zhengang Shan Zhengang Shan Xia Rong Xia Rong Xia Rong Yongshui Fu Yongshui Fu Yongshui Fu Yongshui Fu |
| author_facet | Ru Xu Ru Xu Dandan Song Min Wang Min Wang Jieting Huang Jieting Huang Qiao Liao Qiao Liao Zhengang Shan Zhengang Shan Xia Rong Xia Rong Xia Rong Yongshui Fu Yongshui Fu Yongshui Fu Yongshui Fu |
| author_sort | Ru Xu |
| collection | DOAJ |
| description | The residents of Baisha, a county of Hainan Island, mainly composed of Li ethnic population and relatively closed living environment with its unique geographical location. Our previous study showed that Li ethnic population of Baisha is an endemic center for hepatitis C virus, with significantly higher rates than in other parts of China. However, the epidemiology of HBV in this region remains unclear. Therefore, we conducted a comprehensive epidemiological survey of HBV in Baisha County, including 1,682 Li ethnic residents. The total seropositive rate for HBsAg was 10.2% and was higher than other parts of China. HBV-positive status was associated with the 20–40-year-old group (OR = 1.27, 95%CI 1.04–1.39, P < 0.01) and alcohol consumption (OR = 2.17, 95%CI 1.58–2.99, P < 0.01). Phylogenetic analysis showed that HBV subgenotype D3 was predominant in Baisha County which was first discovered in China, followed by C5, C1, B2, and undetermined subgenotypes which were significantly different from other geographical distribution of main genotypes in China. The most recent common ancestor (tMRCA) of the HBV genotype C in the Li ethnic of Baisha County was 1846 (95%CI: 1739–1932), and Baisha-C5 was earlier than Baisha-C1 and Baisha-C2. Most Baisha-D3 sequences were concentrated in one bundle and unrelated to those D3 genome sequences elsewhere in the world. According to the phylogenetic tree, D3 was introduced into Baisha County in 1884 (95%CI: 1816–1993) and became a local endemic virus. In conclusion, HBV infection in the Li ethnic group is characterized by a high prevalence rate in 20–40-year-old individuals and a unique genotype distribution which were significantly different from other geographical distribution of main genotypes in China, and subgenotype D3 was first discovered in China. |
| first_indexed | 2024-04-11T17:58:50Z |
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| id | doaj.art-936c3a1e676b417e970a1fa5005b0026 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-11T17:58:50Z |
| publishDate | 2022-02-01 |
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| series | Frontiers in Microbiology |
| spelling | doaj.art-936c3a1e676b417e970a1fa5005b00262022-12-22T04:10:34ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-02-011310.3389/fmicb.2022.837746837746Molecular Epidemiological Characteristics and Risk Factors for Acquiring HBV Among Li Ethnic in Baisha County, Hainan Island-Subgenotype D3 Was First Discovered in ChinaRu Xu0Ru Xu1Dandan Song2Min Wang3Min Wang4Jieting Huang5Jieting Huang6Qiao Liao7Qiao Liao8Zhengang Shan9Zhengang Shan10Xia Rong11Xia Rong12Xia Rong13Yongshui Fu14Yongshui Fu15Yongshui Fu16Yongshui Fu17Institute of Clinical Blood Transfusion, Guangzhou Blood Center, Guangzhou, ChinaThe Key Medical Laboratory of Guangzhou, Guangzhou, ChinaDepartment of Clinical Laboratory, The Fifth People’s Hospital of Zhuhai, Zhuhai, ChinaInstitute of Clinical Blood Transfusion, Guangzhou Blood Center, Guangzhou, ChinaThe Key Medical Laboratory of Guangzhou, Guangzhou, ChinaInstitute of Clinical Blood Transfusion, Guangzhou Blood Center, Guangzhou, ChinaThe Key Medical Laboratory of Guangzhou, Guangzhou, ChinaInstitute of Clinical Blood Transfusion, Guangzhou Blood Center, Guangzhou, ChinaThe Key Medical Laboratory of Guangzhou, Guangzhou, ChinaInstitute of Clinical Blood Transfusion, Guangzhou Blood Center, Guangzhou, ChinaThe Key Medical Laboratory of Guangzhou, Guangzhou, ChinaInstitute of Clinical Blood Transfusion, Guangzhou Blood Center, Guangzhou, ChinaThe Key Medical Laboratory of Guangzhou, Guangzhou, ChinaSchool of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, ChinaInstitute of Clinical Blood Transfusion, Guangzhou Blood Center, Guangzhou, ChinaThe Key Medical Laboratory of Guangzhou, Guangzhou, ChinaSchool of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, ChinaZhujiang Hospital of Southern Medical University, Guangzhou, ChinaThe residents of Baisha, a county of Hainan Island, mainly composed of Li ethnic population and relatively closed living environment with its unique geographical location. Our previous study showed that Li ethnic population of Baisha is an endemic center for hepatitis C virus, with significantly higher rates than in other parts of China. However, the epidemiology of HBV in this region remains unclear. Therefore, we conducted a comprehensive epidemiological survey of HBV in Baisha County, including 1,682 Li ethnic residents. The total seropositive rate for HBsAg was 10.2% and was higher than other parts of China. HBV-positive status was associated with the 20–40-year-old group (OR = 1.27, 95%CI 1.04–1.39, P < 0.01) and alcohol consumption (OR = 2.17, 95%CI 1.58–2.99, P < 0.01). Phylogenetic analysis showed that HBV subgenotype D3 was predominant in Baisha County which was first discovered in China, followed by C5, C1, B2, and undetermined subgenotypes which were significantly different from other geographical distribution of main genotypes in China. The most recent common ancestor (tMRCA) of the HBV genotype C in the Li ethnic of Baisha County was 1846 (95%CI: 1739–1932), and Baisha-C5 was earlier than Baisha-C1 and Baisha-C2. Most Baisha-D3 sequences were concentrated in one bundle and unrelated to those D3 genome sequences elsewhere in the world. According to the phylogenetic tree, D3 was introduced into Baisha County in 1884 (95%CI: 1816–1993) and became a local endemic virus. In conclusion, HBV infection in the Li ethnic group is characterized by a high prevalence rate in 20–40-year-old individuals and a unique genotype distribution which were significantly different from other geographical distribution of main genotypes in China, and subgenotype D3 was first discovered in China.https://www.frontiersin.org/articles/10.3389/fmicb.2022.837746/fullhepatitis B virusrisk factorsepidemiologyLi ethnicHBV genotype |
| spellingShingle | Ru Xu Ru Xu Dandan Song Min Wang Min Wang Jieting Huang Jieting Huang Qiao Liao Qiao Liao Zhengang Shan Zhengang Shan Xia Rong Xia Rong Xia Rong Yongshui Fu Yongshui Fu Yongshui Fu Yongshui Fu Molecular Epidemiological Characteristics and Risk Factors for Acquiring HBV Among Li Ethnic in Baisha County, Hainan Island-Subgenotype D3 Was First Discovered in China Frontiers in Microbiology hepatitis B virus risk factors epidemiology Li ethnic HBV genotype |
| title | Molecular Epidemiological Characteristics and Risk Factors for Acquiring HBV Among Li Ethnic in Baisha County, Hainan Island-Subgenotype D3 Was First Discovered in China |
| title_full | Molecular Epidemiological Characteristics and Risk Factors for Acquiring HBV Among Li Ethnic in Baisha County, Hainan Island-Subgenotype D3 Was First Discovered in China |
| title_fullStr | Molecular Epidemiological Characteristics and Risk Factors for Acquiring HBV Among Li Ethnic in Baisha County, Hainan Island-Subgenotype D3 Was First Discovered in China |
| title_full_unstemmed | Molecular Epidemiological Characteristics and Risk Factors for Acquiring HBV Among Li Ethnic in Baisha County, Hainan Island-Subgenotype D3 Was First Discovered in China |
| title_short | Molecular Epidemiological Characteristics and Risk Factors for Acquiring HBV Among Li Ethnic in Baisha County, Hainan Island-Subgenotype D3 Was First Discovered in China |
| title_sort | molecular epidemiological characteristics and risk factors for acquiring hbv among li ethnic in baisha county hainan island subgenotype d3 was first discovered in china |
| topic | hepatitis B virus risk factors epidemiology Li ethnic HBV genotype |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.837746/full |
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