Iron Pathways and Iron Chelation Approaches in Viral, Microbial, and Fungal Infections
Iron is an essential element required to support the health of organisms. This element is critical for regulating the activities of cellular enzymes including those involved in cellular metabolism and DNA replication. Mechanisms that underlie the tight control of iron levels are crucial in mediating...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/13/10/275 |
| _version_ | 1827705422592606208 |
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| author | Ravneet Chhabra Aishwarya Saha Ashkon Chamani Nicole Schneider Riya Shah Meera Nanjundan |
| author_facet | Ravneet Chhabra Aishwarya Saha Ashkon Chamani Nicole Schneider Riya Shah Meera Nanjundan |
| author_sort | Ravneet Chhabra |
| collection | DOAJ |
| description | Iron is an essential element required to support the health of organisms. This element is critical for regulating the activities of cellular enzymes including those involved in cellular metabolism and DNA replication. Mechanisms that underlie the tight control of iron levels are crucial in mediating the interaction between microorganisms and their host and hence, the spread of infection. Microorganisms including viruses, bacteria, and fungi have differing iron acquisition/utilization mechanisms to support their ability to acquire/use iron (e.g., from free iron and heme). These pathways of iron uptake are associated with promoting their growth and virulence and consequently, their pathogenicity. Thus, controlling microorganismal survival by limiting iron availability may prove feasible through the use of agents targeting their iron uptake pathways and/or use of iron chelators as a means to hinder development of infections. This review will serve to assimilate findings regarding iron and the pathogenicity of specific microorganisms, and furthermore, find whether treating infections mediated by such organisms via iron chelation approaches may have potential clinical benefit. |
| first_indexed | 2024-03-10T16:02:52Z |
| format | Article |
| id | doaj.art-936ca801a4df4a09b8d0a9b6abba3b9b |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T16:02:52Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-936ca801a4df4a09b8d0a9b6abba3b9b2023-11-20T15:07:45ZengMDPI AGPharmaceuticals1424-82472020-09-01131027510.3390/ph13100275Iron Pathways and Iron Chelation Approaches in Viral, Microbial, and Fungal InfectionsRavneet Chhabra0Aishwarya Saha1Ashkon Chamani2Nicole Schneider3Riya Shah4Meera Nanjundan5Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL 33620, USADepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL 33620, USADepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL 33620, USADepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL 33620, USADepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL 33620, USADepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL 33620, USAIron is an essential element required to support the health of organisms. This element is critical for regulating the activities of cellular enzymes including those involved in cellular metabolism and DNA replication. Mechanisms that underlie the tight control of iron levels are crucial in mediating the interaction between microorganisms and their host and hence, the spread of infection. Microorganisms including viruses, bacteria, and fungi have differing iron acquisition/utilization mechanisms to support their ability to acquire/use iron (e.g., from free iron and heme). These pathways of iron uptake are associated with promoting their growth and virulence and consequently, their pathogenicity. Thus, controlling microorganismal survival by limiting iron availability may prove feasible through the use of agents targeting their iron uptake pathways and/or use of iron chelators as a means to hinder development of infections. This review will serve to assimilate findings regarding iron and the pathogenicity of specific microorganisms, and furthermore, find whether treating infections mediated by such organisms via iron chelation approaches may have potential clinical benefit.https://www.mdpi.com/1424-8247/13/10/275hepatitis C virushuman immunodeficiency virusgram-negative bacteriagram-positive bacteriafungiiron chelators |
| spellingShingle | Ravneet Chhabra Aishwarya Saha Ashkon Chamani Nicole Schneider Riya Shah Meera Nanjundan Iron Pathways and Iron Chelation Approaches in Viral, Microbial, and Fungal Infections Pharmaceuticals hepatitis C virus human immunodeficiency virus gram-negative bacteria gram-positive bacteria fungi iron chelators |
| title | Iron Pathways and Iron Chelation Approaches in Viral, Microbial, and Fungal Infections |
| title_full | Iron Pathways and Iron Chelation Approaches in Viral, Microbial, and Fungal Infections |
| title_fullStr | Iron Pathways and Iron Chelation Approaches in Viral, Microbial, and Fungal Infections |
| title_full_unstemmed | Iron Pathways and Iron Chelation Approaches in Viral, Microbial, and Fungal Infections |
| title_short | Iron Pathways and Iron Chelation Approaches in Viral, Microbial, and Fungal Infections |
| title_sort | iron pathways and iron chelation approaches in viral microbial and fungal infections |
| topic | hepatitis C virus human immunodeficiency virus gram-negative bacteria gram-positive bacteria fungi iron chelators |
| url | https://www.mdpi.com/1424-8247/13/10/275 |
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