High-Titer Hepatitis C Virus Production in a Scalable Single-Use High Cell Density Bioreactor

High-Titer Hepatitis C Virus Production in a Scalable Single-Use High Cell Density Bioreactor

Hepatitis C virus (HCV) infections pose a major public health burden due to high chronicity rates and associated morbidity and mortality. A vaccine protecting against chronic infection is not available but would be important for global control of HCV infections. In this study, cell culture-based HCV...

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Bibliographic Details
Main Authors: Anna Offersgaard, Carlos Rene Duarte Hernandez, Anne Finne Pihl, Nandini Prabhakar Venkatesan, Henrik Krarup, Xiangliang Lin, Udo Reichl, Jens Bukh, Yvonne Genzel, Judith Margarete Gottwein
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Vaccines
Subjects:
packed-bed bioreactor
CelCradle™
high cell density cell culture
Huh7.5 cells
whole virus vaccine
inactivated virus vaccine
Online Access:https://www.mdpi.com/2076-393X/10/2/249

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