Relationship between Cardiovascular Risk Factors and Composite Cardiovascular Outcomes in Patients Hospitalized with Takotsubo Syndrome: A Nationwide Analysis
The association of traditional cardiovascular disease (CVD) risk factors with outcomes of Takotsubo syndrome (TTS) is not well-defined. This study examined how modifiable CVD risk factors affect composite cardiovascular outcomes in TTS hospitalizations. TTS admissions were identified using ICD-10 co...
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MDPI AG
2023-09-01
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| Online Access: | https://www.mdpi.com/2076-3271/11/3/62 |
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| author | Nanush Damarlapally Rupak Desai Aanchal Sawhney Jyoti Verma Harroop Singh Klair Dhanush Kolli Birimroz Singh Sibia Vardhan Chalasani Rasya Reddy Jithin Kolli Ikechukwu Ogbu Jyotsna Gummadi |
| author_facet | Nanush Damarlapally Rupak Desai Aanchal Sawhney Jyoti Verma Harroop Singh Klair Dhanush Kolli Birimroz Singh Sibia Vardhan Chalasani Rasya Reddy Jithin Kolli Ikechukwu Ogbu Jyotsna Gummadi |
| author_sort | Nanush Damarlapally |
| collection | DOAJ |
| description | The association of traditional cardiovascular disease (CVD) risk factors with outcomes of Takotsubo syndrome (TTS) is not well-defined. This study examined how modifiable CVD risk factors affect composite cardiovascular outcomes in TTS hospitalizations. TTS admissions were identified using ICD-10 codes and compared for demographics and comorbidities using the 2019 National Inpatient Sample. A multivariable regression examined the association of traditional CVD risk variables with adverse composite cardiovascular outcomes in TTS, controlling for confounders including sociodemographic or hospital-level characteristics and other relevant comorbidities. A total of 16,055 (38.1%) of the 41,855 adult TTS admissions had composite cardiovascular outcomes (TACCO). The TACCO cohort was 81.5% white, 77.3% female, and 72 years old. This group had higher rates of diabetes and peripheral vascular disease (PVD). The results showed that a higher prevalence of diabetes with chronic complications (OR = 1.18) and complicated hypertension (HTN) (OR = 1.1) predicted TACCO, whereas tobacco use disorder (OR = 0.84), hyperlipidemia (OR = 0.76), and uncomplicated HTN (OR = 0.65) (<i>p</i> < 0.001) showed a paradoxical effect with TACCO. TACCO had fewer routine discharges (35.3% vs. 63.4%), longer stays (6 vs. 3 days), and higher median hospital costs (78,309 USD vs. 44,966 USD). This population-based study found that complicated HTN and DM with chronic complications are strongly associated with adverse cardiovascular outcomes in TTS hospitalizations. But still, some risk factors, such as hyperlipidemia and uncomplicated HTN, have counterintuitive effects that require further evaluation. To prevent cardiac events in TTS patients, traditional CVD risk factors must be addressed. |
| first_indexed | 2024-03-10T22:29:10Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3271 |
| language | English |
| last_indexed | 2024-03-10T22:29:10Z |
| publishDate | 2023-09-01 |
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| spelling | doaj.art-936d84fa4fdd4451a99027b5bfbdf7f92023-11-19T11:53:54ZengMDPI AGMedical Sciences2076-32712023-09-011136210.3390/medsci11030062Relationship between Cardiovascular Risk Factors and Composite Cardiovascular Outcomes in Patients Hospitalized with Takotsubo Syndrome: A Nationwide AnalysisNanush Damarlapally0Rupak Desai1Aanchal Sawhney2Jyoti Verma3Harroop Singh Klair4Dhanush Kolli5Birimroz Singh Sibia6Vardhan Chalasani7Rasya Reddy8Jithin Kolli9Ikechukwu Ogbu10Jyotsna Gummadi11Department of Health Sciences, Houston Community College (Coleman), Houston, TX 77030, USAIndependent Researcher, Atlanta, GA 30033, USADepartment of Internal Medicine, Crozer Chester Medical Center, Upland, PA 19015, USADepartment of Internal Medicine, North Alabama Medical Center, Florence, AL 35630, USADepartment of Medicine, Government Medical College, Patiala 147001, IndiaDepartment of Medicine, Kasturba Medical College, Manipal 576104, IndiaDepartment of Medicine, Kasturba Medical College, Manipal 576104, IndiaDepartment of Medicine, Kasturba Medical College, Manipal 576104, IndiaDepartment of Medicine, Kasturba Medical College, Manipal 576104, IndiaDepartment of Medicine, Jagadguru Sri Shivarathreeshwara Medical College, Mysore 570015, IndiaDepartment of Internal Medicine, Mountainview Hospital Sunrise GME, Las Vegas, NV 89128, USADepartment of Medicine, Medstar Franklin Square Medical Center, Baltimore, MD 21237, USAThe association of traditional cardiovascular disease (CVD) risk factors with outcomes of Takotsubo syndrome (TTS) is not well-defined. This study examined how modifiable CVD risk factors affect composite cardiovascular outcomes in TTS hospitalizations. TTS admissions were identified using ICD-10 codes and compared for demographics and comorbidities using the 2019 National Inpatient Sample. A multivariable regression examined the association of traditional CVD risk variables with adverse composite cardiovascular outcomes in TTS, controlling for confounders including sociodemographic or hospital-level characteristics and other relevant comorbidities. A total of 16,055 (38.1%) of the 41,855 adult TTS admissions had composite cardiovascular outcomes (TACCO). The TACCO cohort was 81.5% white, 77.3% female, and 72 years old. This group had higher rates of diabetes and peripheral vascular disease (PVD). The results showed that a higher prevalence of diabetes with chronic complications (OR = 1.18) and complicated hypertension (HTN) (OR = 1.1) predicted TACCO, whereas tobacco use disorder (OR = 0.84), hyperlipidemia (OR = 0.76), and uncomplicated HTN (OR = 0.65) (<i>p</i> < 0.001) showed a paradoxical effect with TACCO. TACCO had fewer routine discharges (35.3% vs. 63.4%), longer stays (6 vs. 3 days), and higher median hospital costs (78,309 USD vs. 44,966 USD). This population-based study found that complicated HTN and DM with chronic complications are strongly associated with adverse cardiovascular outcomes in TTS hospitalizations. But still, some risk factors, such as hyperlipidemia and uncomplicated HTN, have counterintuitive effects that require further evaluation. To prevent cardiac events in TTS patients, traditional CVD risk factors must be addressed.https://www.mdpi.com/2076-3271/11/3/62Takotsubo syndromecardiovascular disease riskhypertensiondiabeteshyperlipidemiasmoking |
| spellingShingle | Nanush Damarlapally Rupak Desai Aanchal Sawhney Jyoti Verma Harroop Singh Klair Dhanush Kolli Birimroz Singh Sibia Vardhan Chalasani Rasya Reddy Jithin Kolli Ikechukwu Ogbu Jyotsna Gummadi Relationship between Cardiovascular Risk Factors and Composite Cardiovascular Outcomes in Patients Hospitalized with Takotsubo Syndrome: A Nationwide Analysis Medical Sciences Takotsubo syndrome cardiovascular disease risk hypertension diabetes hyperlipidemia smoking |
| title | Relationship between Cardiovascular Risk Factors and Composite Cardiovascular Outcomes in Patients Hospitalized with Takotsubo Syndrome: A Nationwide Analysis |
| title_full | Relationship between Cardiovascular Risk Factors and Composite Cardiovascular Outcomes in Patients Hospitalized with Takotsubo Syndrome: A Nationwide Analysis |
| title_fullStr | Relationship between Cardiovascular Risk Factors and Composite Cardiovascular Outcomes in Patients Hospitalized with Takotsubo Syndrome: A Nationwide Analysis |
| title_full_unstemmed | Relationship between Cardiovascular Risk Factors and Composite Cardiovascular Outcomes in Patients Hospitalized with Takotsubo Syndrome: A Nationwide Analysis |
| title_short | Relationship between Cardiovascular Risk Factors and Composite Cardiovascular Outcomes in Patients Hospitalized with Takotsubo Syndrome: A Nationwide Analysis |
| title_sort | relationship between cardiovascular risk factors and composite cardiovascular outcomes in patients hospitalized with takotsubo syndrome a nationwide analysis |
| topic | Takotsubo syndrome cardiovascular disease risk hypertension diabetes hyperlipidemia smoking |
| url | https://www.mdpi.com/2076-3271/11/3/62 |
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