The Emerging Role of Chitosan-based Polymeric Nanoparticles in the Diagnosis and Treatment of Gynecological Cancers
Breast and gynecological cancers are the most common malignancies in females. Early-stage detection and treatment could significantly reduce the mortality rate in patients. However, common treatments such as chemotherapy and radiotherapy fail after a while and lead to recurrence and drug resistance...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2023-10-01
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| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | https://mejc.sums.ac.ir/article_49230_dcd23bee01ccd988c41ce6817a752d2b.pdf |
| _version_ | 1797663419760902144 |
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| author | Babak Arji Roudsari Elham Arkan Cyrus Jalili Kamran Mansouri Mitra Bakhtiary |
| author_facet | Babak Arji Roudsari Elham Arkan Cyrus Jalili Kamran Mansouri Mitra Bakhtiary |
| author_sort | Babak Arji Roudsari |
| collection | DOAJ |
| description | Breast and gynecological cancers are the most common malignancies in females. Early-stage detection and treatment could significantly reduce the mortality rate in patients. However, common treatments such as chemotherapy and radiotherapy fail after a while and lead to recurrence and drug resistance in cancer cells. The recent use of nanotechnology has enabled the development of novel approaches for diagnosing and treating oncological diseases. Chitosan-based polymer nanoparticles (CHPNPs) with unique properties such as non-toxicity, biocompatibility, and anti-carcinogenic effects are promising tools for the clinical development of targeted delivery systems. So far, various methods have been applied to use these nanoparticles in the diagnosis and treatment of various cancers. Identifying the most practical methods is one of the most important challenges in achieving effective treatments. A review of these studies can provide better horizons to realize effective treatment. In this review, we evaluate and discuss the use of CHPNPs from published literature to assess diagnostic and therapeutic strategies in breast and gynecological cancers, including ovarian and uterine neoplasms, as well as their advantages and challenges. |
| first_indexed | 2024-03-11T19:14:20Z |
| format | Article |
| id | doaj.art-936f906e65fc49659e08e6d1d3fa4f8a |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-03-11T19:14:20Z |
| publishDate | 2023-10-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-936f906e65fc49659e08e6d1d3fa4f8a2023-10-09T09:02:56ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872023-10-0114448149710.30476/mejc.2023.95482.177949230The Emerging Role of Chitosan-based Polymeric Nanoparticles in the Diagnosis and Treatment of Gynecological CancersBabak Arji Roudsari0Elham Arkan1Cyrus Jalili2Kamran Mansouri3Mitra Bakhtiary4Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, IranNano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Molecular Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, IranBreast and gynecological cancers are the most common malignancies in females. Early-stage detection and treatment could significantly reduce the mortality rate in patients. However, common treatments such as chemotherapy and radiotherapy fail after a while and lead to recurrence and drug resistance in cancer cells. The recent use of nanotechnology has enabled the development of novel approaches for diagnosing and treating oncological diseases. Chitosan-based polymer nanoparticles (CHPNPs) with unique properties such as non-toxicity, biocompatibility, and anti-carcinogenic effects are promising tools for the clinical development of targeted delivery systems. So far, various methods have been applied to use these nanoparticles in the diagnosis and treatment of various cancers. Identifying the most practical methods is one of the most important challenges in achieving effective treatments. A review of these studies can provide better horizons to realize effective treatment. In this review, we evaluate and discuss the use of CHPNPs from published literature to assess diagnostic and therapeutic strategies in breast and gynecological cancers, including ovarian and uterine neoplasms, as well as their advantages and challenges.https://mejc.sums.ac.ir/article_49230_dcd23bee01ccd988c41ce6817a752d2b.pdfchitosan nanoparticlesnanotechnologybreast neoplasmsovarian neoplasmsuterine neoplasms |
| spellingShingle | Babak Arji Roudsari Elham Arkan Cyrus Jalili Kamran Mansouri Mitra Bakhtiary The Emerging Role of Chitosan-based Polymeric Nanoparticles in the Diagnosis and Treatment of Gynecological Cancers Middle East Journal of Cancer chitosan nanoparticles nanotechnology breast neoplasms ovarian neoplasms uterine neoplasms |
| title | The Emerging Role of Chitosan-based Polymeric Nanoparticles in the Diagnosis and Treatment of Gynecological Cancers |
| title_full | The Emerging Role of Chitosan-based Polymeric Nanoparticles in the Diagnosis and Treatment of Gynecological Cancers |
| title_fullStr | The Emerging Role of Chitosan-based Polymeric Nanoparticles in the Diagnosis and Treatment of Gynecological Cancers |
| title_full_unstemmed | The Emerging Role of Chitosan-based Polymeric Nanoparticles in the Diagnosis and Treatment of Gynecological Cancers |
| title_short | The Emerging Role of Chitosan-based Polymeric Nanoparticles in the Diagnosis and Treatment of Gynecological Cancers |
| title_sort | emerging role of chitosan based polymeric nanoparticles in the diagnosis and treatment of gynecological cancers |
| topic | chitosan nanoparticles nanotechnology breast neoplasms ovarian neoplasms uterine neoplasms |
| url | https://mejc.sums.ac.ir/article_49230_dcd23bee01ccd988c41ce6817a752d2b.pdf |
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