Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole Moiety

A series of new 1,2,3-triazolylphosphonates were synthesized through multicomponent alkyne-azide 1,3-dipolar cycloaddition catalyzed by copper nanoparticles on activated carbon. The reactions were carried out in water and at a very low copper loading as green conditions, leading to the triazolylphos...

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Main Authors: Esteban Bjerg, Joaquín Marchán-García, Gabriel Radivoy, Yanina Moglie, Eduardo Buxaderas
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Chemistry Proceedings
Subjects:
Online Access:https://www.mdpi.com/2673-4583/12/1/9
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author Esteban Bjerg
Joaquín Marchán-García
Gabriel Radivoy
Yanina Moglie
Eduardo Buxaderas
author_facet Esteban Bjerg
Joaquín Marchán-García
Gabriel Radivoy
Yanina Moglie
Eduardo Buxaderas
author_sort Esteban Bjerg
collection DOAJ
description A series of new 1,2,3-triazolylphosphonates were synthesized through multicomponent alkyne-azide 1,3-dipolar cycloaddition catalyzed by copper nanoparticles on activated carbon. The reactions were carried out in water and at a very low copper loading as green conditions, leading to the triazolylphosphonate products in moderate to good yields. Studies into their activity as butyrylcholinesterase inhibitors are underway.
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spelling doaj.art-93708d1d53f448bba5e48e738762bc5f2023-11-18T09:47:43ZengMDPI AGChemistry Proceedings2673-45832022-11-01121910.3390/ecsoc-26-13585Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole MoietyEsteban Bjerg0Joaquín Marchán-García1Gabriel Radivoy2Yanina Moglie3Eduardo Buxaderas4Departamento de Química, INQUISUR-CONICET, Universidad Nacional del Sur, Av. Alem 1253, Bahía Blanca B8000CPB, ArgentinaDepartamento de Química, INQUISUR-CONICET, Universidad Nacional del Sur, Av. Alem 1253, Bahía Blanca B8000CPB, ArgentinaDepartamento de Química, INQUISUR-CONICET, Universidad Nacional del Sur, Av. Alem 1253, Bahía Blanca B8000CPB, ArgentinaDepartamento de Química, INQUISUR-CONICET, Universidad Nacional del Sur, Av. Alem 1253, Bahía Blanca B8000CPB, ArgentinaDepartamento de Química, INQUISUR-CONICET, Universidad Nacional del Sur, Av. Alem 1253, Bahía Blanca B8000CPB, ArgentinaA series of new 1,2,3-triazolylphosphonates were synthesized through multicomponent alkyne-azide 1,3-dipolar cycloaddition catalyzed by copper nanoparticles on activated carbon. The reactions were carried out in water and at a very low copper loading as green conditions, leading to the triazolylphosphonate products in moderate to good yields. Studies into their activity as butyrylcholinesterase inhibitors are underway.https://www.mdpi.com/2673-4583/12/1/9phosphonatestriazolecopper nanoparticles
spellingShingle Esteban Bjerg
Joaquín Marchán-García
Gabriel Radivoy
Yanina Moglie
Eduardo Buxaderas
Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole Moiety
Chemistry Proceedings
phosphonates
triazole
copper nanoparticles
title Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole Moiety
title_full Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole Moiety
title_fullStr Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole Moiety
title_full_unstemmed Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole Moiety
title_short Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole Moiety
title_sort organophosphorus chemistry synthesis of new phosphonic acid derivatives bearing a triazole moiety
topic phosphonates
triazole
copper nanoparticles
url https://www.mdpi.com/2673-4583/12/1/9
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