Co-expressing GroEL–GroES, Ssa1–Sis1 and Bip–PDI chaperones for enhanced intracellular production and partial-wall breaking improved stability of porcine growth hormone

Co-expressing GroEL–GroES, Ssa1–Sis1 and Bip–PDI chaperones for enhanced intracellular production and partial-wall breaking improved stability of porcine growth hormone

Abstract Porcine growth hormone (pGH) is a class of peptide hormones secreted from the pituitary gland, which can significantly improve growth and feed utilization of pigs. However, it is unstable and volatile in vitro. It needs to be encapsulated in liposomes when feeding livestock, whose high cost...

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Bibliographic Details
Main Authors: Jinbo Deng, Jiaoqing Li, Miaopeng Ma, Peijing Zhao, Feiping Ming, Zhipeng Lu, Juqing Shi, Qin Fan, Qianyi Liang, Junhao Jia, Jiayi Li, Shuxia Zhang, Linghua Zhang
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Microbial Cell Factories
Subjects:
Porcine growth hormone
Pichia pastoris
Molecular chaperones
Intracellular soluble expression
Partial broken-wall
Online Access:http://link.springer.com/article/10.1186/s12934-020-01304-5

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