The genetic legacy of the Hunyadi descendants
The Hunyadi family is one of the most influential families in the history of Central Europe in the 14th–16th centuries. The family’s prestige was established by Johannes Hunyadi, a Turk-beater who rose to the position of governor of the Kingdom of Hungary. His second son, Matthias Hunyadi, became th...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022030195 |
| _version_ | 1811321546461937664 |
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| author | Endre Neparáczki Luca Kis Zoltán Maróti Bence Kovács Gergely I.B. Varga Miklós Makoldi Pamjav Horolma Éva Teiszler Balázs Tihanyi Péter L. Nagy Kitti Maár Attila Gyenesei Oszkár Schütz Eszter Dudás Tibor Török Vesna Pascuttini-Juraga Ivančica Peharda László Tamás Vizi Gábor Horváth-Lugossy Miklós Kásler |
| author_facet | Endre Neparáczki Luca Kis Zoltán Maróti Bence Kovács Gergely I.B. Varga Miklós Makoldi Pamjav Horolma Éva Teiszler Balázs Tihanyi Péter L. Nagy Kitti Maár Attila Gyenesei Oszkár Schütz Eszter Dudás Tibor Török Vesna Pascuttini-Juraga Ivančica Peharda László Tamás Vizi Gábor Horváth-Lugossy Miklós Kásler |
| author_sort | Endre Neparáczki |
| collection | DOAJ |
| description | The Hunyadi family is one of the most influential families in the history of Central Europe in the 14th–16th centuries. The family’s prestige was established by Johannes Hunyadi, a Turk-beater who rose to the position of governor of the Kingdom of Hungary. His second son, Matthias Hunyadi, became the elected ruler of the Kingdom of Hungary in 1458. The Hunyadi family had unknown origin. Moreover, Matthias failed to found a dynasty because of lacking a legitimate heir and his illegitimate son Johannes Corvinus was unable to obtain the crown. His grandson, Christophorus Corvinus, died in childhood, thus the direct male line of the family ended.In the framework of on interdisciplinary research, we have determined the whole genome sequences of Johannes Corvinus and Christophorus Corvinus by next-generation sequencing technology. Both of them carried the Y-chromosome haplogroup is E1b1b1a1b1a6a1c ∼, which is widespread in Eurasia. The father-son relationship was verified using the classical STR method and whole genome data. Christophorus Corvinus belongs to the rare, sporadically occurring T2c1+146 mitochondrial haplogroup, most frequent around the Mediterranean, while his father belongs to the T2b mitochondrial haplogroup, widespread in Eurasia, both are consistent with the known origin of the mothers. Archaeogenomic analysis indicated that the Corvinus had an ancient European genome composition.Based on the reported genetic data, it will be possible to identify all the other Hunyadi family member, whose only known grave site is known, but who are resting assorted with several other skeletons. |
| first_indexed | 2024-04-13T13:19:12Z |
| format | Article |
| id | doaj.art-93732f9940704f35a075183b9b5d9c4c |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-13T13:19:12Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-93732f9940704f35a075183b9b5d9c4c2022-12-22T02:45:22ZengElsevierHeliyon2405-84402022-11-01811e11731The genetic legacy of the Hunyadi descendantsEndre Neparáczki0Luca Kis1Zoltán Maróti2Bence Kovács3Gergely I.B. Varga4Miklós Makoldi5Pamjav Horolma6 Éva Teiszler7Balázs Tihanyi8Péter L. Nagy9Kitti Maár10Attila Gyenesei11Oszkár Schütz12Eszter Dudás13Tibor Török14Vesna Pascuttini-Juraga15Ivančica Peharda16László Tamás Vizi17Gábor Horváth-Lugossy18Miklós Kásler19Department of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary; Department of Genetics, University of Szeged, Szeged, Hungary; Corresponding author.Department of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary; Department of Biological Anthropology, University of Szeged, Szeged, HungaryDepartment of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary; Department of Pediatrics and Pediatric Health Center, University of Szeged, Szeged, HungaryDepartment of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary; Department of Genetics, University of Szeged, Szeged, HungaryDepartment of Archaeogenetics, Institute of Hungarian Research, Budapest, HungaryDepartment of Archaeology, Institute of Hungarian Research, Budapest, HungaryInstitute of Forensic Genetics, Hungarian Institute for Forensic Sciences, Budapest, HungaryDepartment of History, Institute of Hungarian Research, Budapest, HungaryDepartment of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary; Department of Biological Anthropology, University of Szeged, Szeged, HungaryPraxis Genomics LLC, Atlanta, GA, USADepartment of Genetics, University of Szeged, Szeged, HungaryGenomics and Bioinformatics Core Facility, Szentágothai Research Centre, University of Pécs, Pécs, HungaryDepartment of Genetics, University of Szeged, Szeged, HungaryInstitute of Forensic Genetics, Hungarian Institute for Forensic Sciences, Budapest, HungaryDepartment of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary; Department of Genetics, University of Szeged, Szeged, HungaryMinistry of Culture and Media, Conservation Department in Varaždin for the Areas of the Varaždin and Međimurje Counties, Varazdin, CroatiaMinistry of Culture and Media, Conservation Department in Varaždin for the Areas of the Varaždin and Međimurje Counties, Varazdin, CroatiaDepartment of History, Institute of Hungarian Research, Budapest, HungaryInstitute of Hungarian Research, Budapest, HungaryNational Institute of Oncology, Budapest, Hungary; Minister of Human Capacities of the Republic of Hungary, Budapest, HungaryThe Hunyadi family is one of the most influential families in the history of Central Europe in the 14th–16th centuries. The family’s prestige was established by Johannes Hunyadi, a Turk-beater who rose to the position of governor of the Kingdom of Hungary. His second son, Matthias Hunyadi, became the elected ruler of the Kingdom of Hungary in 1458. The Hunyadi family had unknown origin. Moreover, Matthias failed to found a dynasty because of lacking a legitimate heir and his illegitimate son Johannes Corvinus was unable to obtain the crown. His grandson, Christophorus Corvinus, died in childhood, thus the direct male line of the family ended.In the framework of on interdisciplinary research, we have determined the whole genome sequences of Johannes Corvinus and Christophorus Corvinus by next-generation sequencing technology. Both of them carried the Y-chromosome haplogroup is E1b1b1a1b1a6a1c ∼, which is widespread in Eurasia. The father-son relationship was verified using the classical STR method and whole genome data. Christophorus Corvinus belongs to the rare, sporadically occurring T2c1+146 mitochondrial haplogroup, most frequent around the Mediterranean, while his father belongs to the T2b mitochondrial haplogroup, widespread in Eurasia, both are consistent with the known origin of the mothers. Archaeogenomic analysis indicated that the Corvinus had an ancient European genome composition.Based on the reported genetic data, it will be possible to identify all the other Hunyadi family member, whose only known grave site is known, but who are resting assorted with several other skeletons.http://www.sciencedirect.com/science/article/pii/S2405844022030195Ancient genomesHunyadiCorvinusHungarian Nobel family |
| spellingShingle | Endre Neparáczki Luca Kis Zoltán Maróti Bence Kovács Gergely I.B. Varga Miklós Makoldi Pamjav Horolma Éva Teiszler Balázs Tihanyi Péter L. Nagy Kitti Maár Attila Gyenesei Oszkár Schütz Eszter Dudás Tibor Török Vesna Pascuttini-Juraga Ivančica Peharda László Tamás Vizi Gábor Horváth-Lugossy Miklós Kásler The genetic legacy of the Hunyadi descendants Heliyon Ancient genomes Hunyadi Corvinus Hungarian Nobel family |
| title | The genetic legacy of the Hunyadi descendants |
| title_full | The genetic legacy of the Hunyadi descendants |
| title_fullStr | The genetic legacy of the Hunyadi descendants |
| title_full_unstemmed | The genetic legacy of the Hunyadi descendants |
| title_short | The genetic legacy of the Hunyadi descendants |
| title_sort | genetic legacy of the hunyadi descendants |
| topic | Ancient genomes Hunyadi Corvinus Hungarian Nobel family |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022030195 |
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