Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein S1 Induces Methylglyoxal-Derived Hydroimidazolone/Receptor for Advanced Glycation End Products (MG-H1/RAGE) Activation to Promote Inflammation in Human Bronchial BEAS-2B Cells

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein S1 Induces Methylglyoxal-Derived Hydroimidazolone/Receptor for Advanced Glycation End Products (MG-H1/RAGE) Activation to Promote Inflammation in Human Bronchial BEAS-2B Cells

The pathogenesis of coronavirus disease 2019 (COVID-19) is associated with a hyperinflammatory response. The mechanisms of SARS-CoV-2-induced inflammation are scantly known. Methylglyoxal (MG) is a glycolysis-derived byproduct endowed with a potent glycating action, leading to the formation of advan...

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Bibliographic Details
Main Authors: Dominga Manfredelli, Marilena Pariano, Claudio Costantini, Alessandro Graziani, Silvia Bozza, Luigina Romani, Paolo Puccetti, Vincenzo Nicola Talesa, Cinzia Antognelli
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
COVID-19
methylglyoxal
methylglyoxal-derived AGEs
Nrf2
A549
Online Access:https://www.mdpi.com/1422-0067/24/19/14868

Internet

https://www.mdpi.com/1422-0067/24/19/14868

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