Study of Immobilization by Esteric Bond of 2-(m-Nitrophenyl)-4-(ОІ- Carboxymethyl)-О”2-Oxazolinone-5 on Gellan
The paper studies the coupling reaction, through ester-type covalent bonds, of an oxazolone derived from the N-(m-nitrobenzoyl)-L-asparagic acid, on gellan (a polysaccharide of microbian synthesis), in conditions of activation with dicyclohexyl carbodiimide. Based on a centered, rotatory, composed,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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al-Farabi Kazakh National University
2003-04-01
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| Series: | Eurasian Chemico-Technological Journal |
| Online Access: | http://ect-journal.kz/index.php/ectj/article/view/466 |
| _version_ | 1811322119854751744 |
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| author | Popa Marcel Sunel Valeriu Balaita Rusu Lacramioara Basu Cristina |
| author_facet | Popa Marcel Sunel Valeriu Balaita Rusu Lacramioara Basu Cristina |
| author_sort | Popa Marcel |
| collection | DOAJ |
| description | The paper studies the coupling reaction, through ester-type covalent bonds, of an oxazolone derived from the N-(m-nitrobenzoyl)-L-asparagic acid, on gellan (a polysaccharide of microbian synthesis), in conditions of activation with dicyclohexyl carbodiimide. Based on a centered, rotatory, composed, second order experimental program, the regression equation describing the dependence of the amount of active principle, chemically bounded to the support, on the reaction’s parameters (support/active principle ratio, active principle/activator ratio, duration) is obtained. One may observe that the efficiency of the coupling reaction is maximum when employing the parameters’ highest values, over the variation domain established. The coupling product has been characterized through elemental analysis and IR spectroscopy. For the establishment of the capacity of the active principle’s controlled release by the polymer-active principle system thus obtained, drug’s release kinetics from the polysaccharidic support is studied in conditions of basic hydrolysis. The oxazolone release from the coupling products, by basic hydrolysis proceeds conformely to a zero order kinetics, proving their retard activity. |
| first_indexed | 2024-04-13T13:29:34Z |
| format | Article |
| id | doaj.art-93745adfb5b74d51a11adb3a33433d75 |
| institution | Directory Open Access Journal |
| issn | 1562-3920 2522-4867 |
| language | English |
| last_indexed | 2024-04-13T13:29:34Z |
| publishDate | 2003-04-01 |
| publisher | al-Farabi Kazakh National University |
| record_format | Article |
| series | Eurasian Chemico-Technological Journal |
| spelling | doaj.art-93745adfb5b74d51a11adb3a33433d752022-12-22T02:45:02Zengal-Farabi Kazakh National UniversityEurasian Chemico-Technological Journal1562-39202522-48672003-04-015212112610.18321/ectj291466Study of Immobilization by Esteric Bond of 2-(m-Nitrophenyl)-4-(ОІ- Carboxymethyl)-О”2-Oxazolinone-5 on GellanPopa Marcel0Sunel Valeriu1Balaita Rusu Lacramioara2Basu Cristina3Technical University “Gh.Asachi” of Iasi, Department of Macromolecules, Bd. D. Mangeron 71A, 6600 Iasi, RomaniaUniversity “Al.I.Cuza” of Iasi, Departament of Organic Chemistry, Bd. Copou 11, 6600, Iasi, RomaniaTechnical University “Gh.Asachi” of Iasi, Department of Macromolecules, Bd. D. Mangeron 71A, 6600 Iasi, RomaniaResearch&Development Department, S.C. Antibiotice S.A., 1 Valea Lupului Street, 6600 Iasi, RomaniaThe paper studies the coupling reaction, through ester-type covalent bonds, of an oxazolone derived from the N-(m-nitrobenzoyl)-L-asparagic acid, on gellan (a polysaccharide of microbian synthesis), in conditions of activation with dicyclohexyl carbodiimide. Based on a centered, rotatory, composed, second order experimental program, the regression equation describing the dependence of the amount of active principle, chemically bounded to the support, on the reaction’s parameters (support/active principle ratio, active principle/activator ratio, duration) is obtained. One may observe that the efficiency of the coupling reaction is maximum when employing the parameters’ highest values, over the variation domain established. The coupling product has been characterized through elemental analysis and IR spectroscopy. For the establishment of the capacity of the active principle’s controlled release by the polymer-active principle system thus obtained, drug’s release kinetics from the polysaccharidic support is studied in conditions of basic hydrolysis. The oxazolone release from the coupling products, by basic hydrolysis proceeds conformely to a zero order kinetics, proving their retard activity.http://ect-journal.kz/index.php/ectj/article/view/466 |
| spellingShingle | Popa Marcel Sunel Valeriu Balaita Rusu Lacramioara Basu Cristina Study of Immobilization by Esteric Bond of 2-(m-Nitrophenyl)-4-(ОІ- Carboxymethyl)-О”2-Oxazolinone-5 on Gellan Eurasian Chemico-Technological Journal |
| title | Study of Immobilization by Esteric Bond of 2-(m-Nitrophenyl)-4-(ОІ- Carboxymethyl)-О”2-Oxazolinone-5 on Gellan |
| title_full | Study of Immobilization by Esteric Bond of 2-(m-Nitrophenyl)-4-(ОІ- Carboxymethyl)-О”2-Oxazolinone-5 on Gellan |
| title_fullStr | Study of Immobilization by Esteric Bond of 2-(m-Nitrophenyl)-4-(ОІ- Carboxymethyl)-О”2-Oxazolinone-5 on Gellan |
| title_full_unstemmed | Study of Immobilization by Esteric Bond of 2-(m-Nitrophenyl)-4-(ОІ- Carboxymethyl)-О”2-Oxazolinone-5 on Gellan |
| title_short | Study of Immobilization by Esteric Bond of 2-(m-Nitrophenyl)-4-(ОІ- Carboxymethyl)-О”2-Oxazolinone-5 on Gellan |
| title_sort | study of immobilization by esteric bond of 2 m nitrophenyl 4 оі carboxymethyl о 2 oxazolinone 5 on gellan |
| url | http://ect-journal.kz/index.php/ectj/article/view/466 |
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