Interaction between Polyphenolic Antioxidants and <i>Saccharomyces cerevisiae</i> Cells Defective in Heavy Metal Transport across the Plasma Membrane
Natural polyphenols are compounds with important biological implications which include antioxidant and metal-chelating characteristics relevant for their antimicrobial, antitumor, or antiaging potential. The mechanisms linking polyphenols and heavy metals in their concerted actions on cells are not...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/11/1512 |
| _version_ | 1797548824171905024 |
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| author | Lavinia Liliana Ruta Ileana Cornelia Farcasanu |
| author_facet | Lavinia Liliana Ruta Ileana Cornelia Farcasanu |
| author_sort | Lavinia Liliana Ruta |
| collection | DOAJ |
| description | Natural polyphenols are compounds with important biological implications which include antioxidant and metal-chelating characteristics relevant for their antimicrobial, antitumor, or antiaging potential. The mechanisms linking polyphenols and heavy metals in their concerted actions on cells are not completely elucidated. In this study, we used the model eukaryotic microorganism <i>Saccharomyces cerevisiae</i> to detect the action of widely prevalent natural polyphenols on yeast cells defective in the main components involved in essential heavy metal transport across the plasma membrane. We found that caffeic and gallic acids interfered with Zn accumulation, causing delays in cell growth that were alleviated by Zn supplementation. The flavones morin and quercetin interfered with both Mn and Zn accumulation, which resulted in growth improvement, but supplemental Mn and especially Zn turned the initially benefic action of morin and quercetin into potential toxicity. Our results imply that caution is needed when administering food supplements or nutraceuticals which contain both natural polyphenols and essential elements, especially zinc. |
| first_indexed | 2024-03-10T15:05:14Z |
| format | Article |
| id | doaj.art-9374ec4dd7f44c2eb42c4b7d5a0913d5 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T15:05:14Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-9374ec4dd7f44c2eb42c4b7d5a0913d52023-11-20T19:49:15ZengMDPI AGBiomolecules2218-273X2020-11-011011151210.3390/biom10111512Interaction between Polyphenolic Antioxidants and <i>Saccharomyces cerevisiae</i> Cells Defective in Heavy Metal Transport across the Plasma MembraneLavinia Liliana Ruta0Ileana Cornelia Farcasanu1Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, Sos. Panduri 90–92, 050663 Bucharest, RomaniaDepartment of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, Sos. Panduri 90–92, 050663 Bucharest, RomaniaNatural polyphenols are compounds with important biological implications which include antioxidant and metal-chelating characteristics relevant for their antimicrobial, antitumor, or antiaging potential. The mechanisms linking polyphenols and heavy metals in their concerted actions on cells are not completely elucidated. In this study, we used the model eukaryotic microorganism <i>Saccharomyces cerevisiae</i> to detect the action of widely prevalent natural polyphenols on yeast cells defective in the main components involved in essential heavy metal transport across the plasma membrane. We found that caffeic and gallic acids interfered with Zn accumulation, causing delays in cell growth that were alleviated by Zn supplementation. The flavones morin and quercetin interfered with both Mn and Zn accumulation, which resulted in growth improvement, but supplemental Mn and especially Zn turned the initially benefic action of morin and quercetin into potential toxicity. Our results imply that caution is needed when administering food supplements or nutraceuticals which contain both natural polyphenols and essential elements, especially zinc.https://www.mdpi.com/2218-273X/10/11/1512polyphenolsheavy metalstransport<i>Saccharomyces cerevisiae</i> |
| spellingShingle | Lavinia Liliana Ruta Ileana Cornelia Farcasanu Interaction between Polyphenolic Antioxidants and <i>Saccharomyces cerevisiae</i> Cells Defective in Heavy Metal Transport across the Plasma Membrane Biomolecules polyphenols heavy metals transport <i>Saccharomyces cerevisiae</i> |
| title | Interaction between Polyphenolic Antioxidants and <i>Saccharomyces cerevisiae</i> Cells Defective in Heavy Metal Transport across the Plasma Membrane |
| title_full | Interaction between Polyphenolic Antioxidants and <i>Saccharomyces cerevisiae</i> Cells Defective in Heavy Metal Transport across the Plasma Membrane |
| title_fullStr | Interaction between Polyphenolic Antioxidants and <i>Saccharomyces cerevisiae</i> Cells Defective in Heavy Metal Transport across the Plasma Membrane |
| title_full_unstemmed | Interaction between Polyphenolic Antioxidants and <i>Saccharomyces cerevisiae</i> Cells Defective in Heavy Metal Transport across the Plasma Membrane |
| title_short | Interaction between Polyphenolic Antioxidants and <i>Saccharomyces cerevisiae</i> Cells Defective in Heavy Metal Transport across the Plasma Membrane |
| title_sort | interaction between polyphenolic antioxidants and i saccharomyces cerevisiae i cells defective in heavy metal transport across the plasma membrane |
| topic | polyphenols heavy metals transport <i>Saccharomyces cerevisiae</i> |
| url | https://www.mdpi.com/2218-273X/10/11/1512 |
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