Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity
Annona muricata L. (Magnoliales: Annonaceae) is a tropical plant species known for its edible fruit which has some medicinal merits, but also some toxicological effects. This review focuses on the phytochemicals contents, bioactivity, biological actions and toxicological aspects of extracts and isol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-07-01
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| Series: | Arabian Journal of Chemistry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535216000058 |
| _version_ | 1818691638163144704 |
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| author | Ana V. Coria-Téllez Efigenia Montalvo-Gónzalez Elhadi M. Yahia Eva N. Obledo-Vázquez |
| author_facet | Ana V. Coria-Téllez Efigenia Montalvo-Gónzalez Elhadi M. Yahia Eva N. Obledo-Vázquez |
| author_sort | Ana V. Coria-Téllez |
| collection | DOAJ |
| description | Annona muricata L. (Magnoliales: Annonaceae) is a tropical plant species known for its edible fruit which has some medicinal merits, but also some toxicological effects. This review focuses on the phytochemicals contents, bioactivity, biological actions and toxicological aspects of extracts and isolated compounds, as well as medicinal uses of A. muricata, with the objective of stimulating further studies on extracts and fruit pulp used for human consumption. Traditional medicinal uses of A. muricata have been identified in tropical regions to treat diverse ailments such as fever, pain, respiratory and skin illness, internal and external parasites, bacterial infections, hypertension, inflammation, diabetes and cancer. More than 200 chemical compounds have been identified and isolated from this plant; the most important being alkaloids, phenols and acetogenins. Using in vitro studies, extracts and phytochemicals of A. muricata have been characterized as an antimicrobial, anti-inflammatory, anti-protozoan, antioxidant, insecticide, larvicide, and cytotoxic to tumor cells. In vivo studies of the crude extracts and isolated compounds of A. muricata were shown to possess anxiolytic, anti-stress, anti-inflammatory, contraceptive, anti-tumoral, antiulceric, wound healing, hepato-protective, anti-icteric and hypoglycemic activities. In addition, clinical studies support the hypoglycemic activity of the ethanolic extracts of A. muricata leaves. Mechanisms of action of some pharmacological activities have been elucidated, such as cytotoxic, antioxidant, antimicrobial, antinociception and hypotensive activities. However, some phytochemical compounds isolated from A. muricata have shown a neurotoxic effect in vitro and in vivo, and therefore, these crude extracts and isolated compounds need to be further investigated to define the magnitude of the effects, optimal dosage, mechanisms of action, long-term safety, and potential side effects. Additionally, clinical studies are necessary to support the therapeutic potential of this plant. Keywords: Annona muricata, Traditional medicine, Phytochemicals, Bioactivity, Cytotoxicity, Health |
| first_indexed | 2024-12-17T12:45:04Z |
| format | Article |
| id | doaj.art-937731b498244482bf84bae56e96a3ac |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-17T12:45:04Z |
| publishDate | 2018-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-937731b498244482bf84bae56e96a3ac2022-12-21T21:47:46ZengElsevierArabian Journal of Chemistry1878-53522018-07-01115662691Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicityAna V. Coria-Téllez0Efigenia Montalvo-Gónzalez1Elhadi M. Yahia2Eva N. Obledo-Vázquez3Laboratorio de Análisis y Diagnóstico del Patrimonio, El Colegio de Michoacán A.C., Cerro de Nahuatzen No. 85, Fracc. Jardines del Cerro Grande, La Piedad, C.P. 59370 Michoacán, Mexico; Unidad de Biotecnología Vegetal, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Av. Normalistas No. 800, Col. Colinas de la Normal, Guadalajara, C.P. 44270 Jalisco, MexicoLaboratorio Integral de Investigación en Alimentos, Instituto Tecnológico de Tepic, Av. Tecnológico 2595, C.P. 63175 Tepic, Nayarit, MexicoFacultad de Ciencias Naturales, Universidad Autonoma de Queretaro, Avenida de las Ciencias S/N, Juriquilla, 76230 Queretaro, Qro., MexicoUnidad de Biotecnología Vegetal, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Av. Normalistas No. 800, Col. Colinas de la Normal, Guadalajara, C.P. 44270 Jalisco, Mexico; Corresponding author. Tel.: +52 (33) 33 45 52 00.Annona muricata L. (Magnoliales: Annonaceae) is a tropical plant species known for its edible fruit which has some medicinal merits, but also some toxicological effects. This review focuses on the phytochemicals contents, bioactivity, biological actions and toxicological aspects of extracts and isolated compounds, as well as medicinal uses of A. muricata, with the objective of stimulating further studies on extracts and fruit pulp used for human consumption. Traditional medicinal uses of A. muricata have been identified in tropical regions to treat diverse ailments such as fever, pain, respiratory and skin illness, internal and external parasites, bacterial infections, hypertension, inflammation, diabetes and cancer. More than 200 chemical compounds have been identified and isolated from this plant; the most important being alkaloids, phenols and acetogenins. Using in vitro studies, extracts and phytochemicals of A. muricata have been characterized as an antimicrobial, anti-inflammatory, anti-protozoan, antioxidant, insecticide, larvicide, and cytotoxic to tumor cells. In vivo studies of the crude extracts and isolated compounds of A. muricata were shown to possess anxiolytic, anti-stress, anti-inflammatory, contraceptive, anti-tumoral, antiulceric, wound healing, hepato-protective, anti-icteric and hypoglycemic activities. In addition, clinical studies support the hypoglycemic activity of the ethanolic extracts of A. muricata leaves. Mechanisms of action of some pharmacological activities have been elucidated, such as cytotoxic, antioxidant, antimicrobial, antinociception and hypotensive activities. However, some phytochemical compounds isolated from A. muricata have shown a neurotoxic effect in vitro and in vivo, and therefore, these crude extracts and isolated compounds need to be further investigated to define the magnitude of the effects, optimal dosage, mechanisms of action, long-term safety, and potential side effects. Additionally, clinical studies are necessary to support the therapeutic potential of this plant. Keywords: Annona muricata, Traditional medicine, Phytochemicals, Bioactivity, Cytotoxicity, Healthhttp://www.sciencedirect.com/science/article/pii/S1878535216000058 |
| spellingShingle | Ana V. Coria-Téllez Efigenia Montalvo-Gónzalez Elhadi M. Yahia Eva N. Obledo-Vázquez Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity Arabian Journal of Chemistry |
| title | Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity |
| title_full | Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity |
| title_fullStr | Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity |
| title_full_unstemmed | Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity |
| title_short | Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity |
| title_sort | annona muricata a comprehensive review on its traditional medicinal uses phytochemicals pharmacological activities mechanisms of action and toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S1878535216000058 |
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