SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19

SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19

Here, the authors report accelerated intrahost evolution of SARS-CoV-2 in an immunocompromised patient with non-Hodgkin’s lymphoma with 318 days long COVID-19, and show that changes in the viral genome resulted in escape from T cellular immune response.

Bibliographic Details
Main Authors: Oksana V. Stanevich, Evgeniia I. Alekseeva, Maria Sergeeva, Artem V. Fadeev, Kseniya S. Komissarova, Anna A. Ivanova, Tamara S. Simakova, Kirill A. Vasilyev, Anna-Polina Shurygina, Marina A. Stukova, Ksenia R. Safina, Elena R. Nabieva, Sofya K. Garushyants, Galya V. Klink, Evgeny A. Bakin, Jullia V. Zabutova, Anastasia N. Kholodnaia, Olga V. Lukina, Irina A. Skorokhod, Viktoria V. Ryabchikova, Nadezhda V. Medvedeva, Dmitry A. Lioznov, Daria M. Danilenko, Dmitriy M. Chudakov, Andrey B. Komissarov, Georgii A. Bazykin
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34033-x

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