FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors

Epidemiological and phenomenological studies suggest shared underpinnings between multiple addictive behaviors. The present genetic association study was conducted as part of the Psychological and Genetic Factors of Addictions study (<i>n</i> = 3003) and aimed to investigate genetic over...

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Main Authors: Andrea Vereczkei, Csaba Barta, Anna Magi, Judit Farkas, Andrea Eisinger, Orsolya Király, Andrea Belik, Mark D. Griffiths, Anna Szekely, Mária Sasvári-Székely, Róbert Urbán, Marc N. Potenza, Rajendra D. Badgaiyan, Kenneth Blum, Zsolt Demetrovics, Eszter Kotyuk
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Journal of Personalized Medicine
Subjects:
Online Access:https://www.mdpi.com/2075-4426/12/5/690
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author Andrea Vereczkei
Csaba Barta
Anna Magi
Judit Farkas
Andrea Eisinger
Orsolya Király
Andrea Belik
Mark D. Griffiths
Anna Szekely
Mária Sasvári-Székely
Róbert Urbán
Marc N. Potenza
Rajendra D. Badgaiyan
Kenneth Blum
Zsolt Demetrovics
Eszter Kotyuk
author_facet Andrea Vereczkei
Csaba Barta
Anna Magi
Judit Farkas
Andrea Eisinger
Orsolya Király
Andrea Belik
Mark D. Griffiths
Anna Szekely
Mária Sasvári-Székely
Róbert Urbán
Marc N. Potenza
Rajendra D. Badgaiyan
Kenneth Blum
Zsolt Demetrovics
Eszter Kotyuk
author_sort Andrea Vereczkei
collection DOAJ
description Epidemiological and phenomenological studies suggest shared underpinnings between multiple addictive behaviors. The present genetic association study was conducted as part of the Psychological and Genetic Factors of Addictions study (<i>n</i> = 3003) and aimed to investigate genetic overlaps between different substance use, addictive, and other compulsive behaviors. Association analyses targeted 32 single-nucleotide polymorphisms, potentially addictive substances (alcohol, tobacco, cannabis, and other drugs), and potentially addictive or compulsive behaviors (internet use, gaming, social networking site use, gambling, exercise, hair-pulling, and eating). Analyses revealed 29 nominally significant associations, from which, nine survived an FDRbl correction. Four associations were observed between FOXN3 rs759364 and potentially addictive behaviors: rs759364 showed an association with the frequency of alcohol consumption and mean scores of scales assessing internet addiction, gaming disorder, and exercise addiction. Significant associations were found between GDNF rs1549250, rs2973033, CNR1 rs806380, DRD2/ANKK1 rs1800497 variants, and the “lifetime other drugs” variable. These suggested that genetic factors may contribute similarly to specific substance use and addictive behaviors. Specifically, FOXN3 rs759364 and GDNF rs1549250 and rs2973033 may constitute genetic risk factors for multiple addictive behaviors. Due to limitations (e.g., convenience sampling, lack of structured scales for substance use), further studies are needed. Functional correlates and mechanisms underlying these relationships should also be investigated.
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spelling doaj.art-93788f283af14fc898f6957c413e210d2023-11-23T11:43:13ZengMDPI AGJournal of Personalized Medicine2075-44262022-04-0112569010.3390/jpm12050690FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive BehaviorsAndrea Vereczkei0Csaba Barta1Anna Magi2Judit Farkas3Andrea Eisinger4Orsolya Király5Andrea Belik6Mark D. Griffiths7Anna Szekely8Mária Sasvári-Székely9Róbert Urbán10Marc N. Potenza11Rajendra D. Badgaiyan12Kenneth Blum13Zsolt Demetrovics14Eszter Kotyuk15Department of Molecular Biology, Institute of Biochemistry and Molecular Biology, Semmelweis University, 1094 Budapest, HungaryDepartment of Molecular Biology, Institute of Biochemistry and Molecular Biology, Semmelweis University, 1094 Budapest, HungaryInstitute of Psychology, ELTE Eötvös Loránd University, 1075 Budapest, HungaryInstitute of Psychology, ELTE Eötvös Loránd University, 1075 Budapest, HungaryInstitute of Psychology, ELTE Eötvös Loránd University, 1075 Budapest, HungaryInstitute of Psychology, ELTE Eötvös Loránd University, 1075 Budapest, HungaryDepartment of Molecular Biology, Institute of Biochemistry and Molecular Biology, Semmelweis University, 1094 Budapest, HungaryInternational Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham NG1 4FQ, UKInstitute of Psychology, ELTE Eötvös Loránd University, 1075 Budapest, HungaryDepartment of Molecular Biology, Institute of Biochemistry and Molecular Biology, Semmelweis University, 1094 Budapest, HungaryInstitute of Psychology, ELTE Eötvös Loránd University, 1075 Budapest, HungaryDepartments of Psychiatry, Child Study and Neuroscience, Yale University School of Medicine, New Haven, CT 06511, USADepartment of Psychiatry, Ichan School of Medicine at Mount Sinai, New York, NY 10029, USADivision of Addiction Research & Education, Center for Psychiatry, Medicine, & Primary Care (Office of the Provost), Western University Health Sciences, Pomona, CA 91766, USAInstitute of Psychology, ELTE Eötvös Loránd University, 1075 Budapest, HungaryInstitute of Psychology, ELTE Eötvös Loránd University, 1075 Budapest, HungaryEpidemiological and phenomenological studies suggest shared underpinnings between multiple addictive behaviors. The present genetic association study was conducted as part of the Psychological and Genetic Factors of Addictions study (<i>n</i> = 3003) and aimed to investigate genetic overlaps between different substance use, addictive, and other compulsive behaviors. Association analyses targeted 32 single-nucleotide polymorphisms, potentially addictive substances (alcohol, tobacco, cannabis, and other drugs), and potentially addictive or compulsive behaviors (internet use, gaming, social networking site use, gambling, exercise, hair-pulling, and eating). Analyses revealed 29 nominally significant associations, from which, nine survived an FDRbl correction. Four associations were observed between FOXN3 rs759364 and potentially addictive behaviors: rs759364 showed an association with the frequency of alcohol consumption and mean scores of scales assessing internet addiction, gaming disorder, and exercise addiction. Significant associations were found between GDNF rs1549250, rs2973033, CNR1 rs806380, DRD2/ANKK1 rs1800497 variants, and the “lifetime other drugs” variable. These suggested that genetic factors may contribute similarly to specific substance use and addictive behaviors. Specifically, FOXN3 rs759364 and GDNF rs1549250 and rs2973033 may constitute genetic risk factors for multiple addictive behaviors. Due to limitations (e.g., convenience sampling, lack of structured scales for substance use), further studies are needed. Functional correlates and mechanisms underlying these relationships should also be investigated.https://www.mdpi.com/2075-4426/12/5/690addictive behaviorsgenetic association analysissubstance usesubstance-related disorders<i>FOXN3</i><i>GDNF</i>
spellingShingle Andrea Vereczkei
Csaba Barta
Anna Magi
Judit Farkas
Andrea Eisinger
Orsolya Király
Andrea Belik
Mark D. Griffiths
Anna Szekely
Mária Sasvári-Székely
Róbert Urbán
Marc N. Potenza
Rajendra D. Badgaiyan
Kenneth Blum
Zsolt Demetrovics
Eszter Kotyuk
FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors
Journal of Personalized Medicine
addictive behaviors
genetic association analysis
substance use
substance-related disorders
<i>FOXN3</i>
<i>GDNF</i>
title FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors
title_full FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors
title_fullStr FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors
title_full_unstemmed FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors
title_short FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors
title_sort foxn3 and gdnf polymorphisms as common genetic factors of substance use and addictive behaviors
topic addictive behaviors
genetic association analysis
substance use
substance-related disorders
<i>FOXN3</i>
<i>GDNF</i>
url https://www.mdpi.com/2075-4426/12/5/690
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