Effect of Acute PM2.5 Exposure on Lung Function in Children: A Systematic Review and Meta-Analysis
Yueming Zhang,1– 3 Ziyao Guo,1,2 Wen Zhang,3 Qinyuan Li,1,2 Yan Zhao,1,2 Zhili Wang,1,2 Zhengxiu Luo1,2 1Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2National Clinical Research Center for Child Health and Disorders,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-05-01
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| Series: | Journal of Asthma and Allergy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/effect-of-acute-pm25-exposure-on-lung-function-in-children-a-systemati-peer-reviewed-fulltext-article-JAA |
| _version_ | 1827949812492795904 |
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| author | Zhang Y Guo Z Zhang W Li Q Zhao Y Wang Z Luo Z |
| author_facet | Zhang Y Guo Z Zhang W Li Q Zhao Y Wang Z Luo Z |
| author_sort | Zhang Y |
| collection | DOAJ |
| description | Yueming Zhang,1– 3 Ziyao Guo,1,2 Wen Zhang,3 Qinyuan Li,1,2 Yan Zhao,1,2 Zhili Wang,1,2 Zhengxiu Luo1,2 1Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, People’s Republic of China; 3Department of Respiratory, Xi’an Children’s Hospital, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Zhengxiu Luo, Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China, Email luozhengxiu816@hospital.cqmu.edu.cnObjective: The objective of this study was to conduct a systematic review and meta-analysis to identify the adverse effects of acute PM2.5 exposure on lung function in children.Design: Systematic review and meta-analysis. Setting, participants and measures: Eligible studies analyzing PM2.5 level and lung function in children were screened out. Effect estimates of PM2.5 measurements were quantified using random effect models. Heterogeneity was investigated with Q-test and I2 statistics. We also conducted meta-regression and sensitivity analysis to explore the sources of heterogeneity, such as different countries and asthmatic status. Subgroup analyses were conducted to determine the effects of acute PM2.5 exposure on children of different asthmatic status and in different countries.Results: A total of 11 studies with 4314 participants from Brazil, China and Japan were included finally. A 10 μg/m3 increase of PM2.5 was associated with a 1.74L/min (95% CI: − 2.68, − 0.90) decrease in peak expiratory flow (PEF). Since the asthmatic status and country could partly explain the heterogeneity, we conducted the subgroup analysis. Children with severe asthma were more susceptible to PM2.5 exposure (− 3.11 L/min per 10 μg/m3 increase, 95% CI − 4.54, − 1.67) than healthy children (− 1.61 L/min per 10 μg/m3 increase, 95% CI − 2.34, − 0.91). In the children of China, PEF decreased by 1.54 L/min (95% CI − 2.33, − 0.75) with a 10 μg/m3 increase in PM2.5 exposure. In the children of Japan, PEF decreased by 2.65 L/min (95% CI − 3.82, − 1.48) with a 10 μg/m3 increase of PM2.5 exposure. In contrast, no statistic association was found between every 10 μg/m3 increase of PM2.5 and lung function in children of Brazil (− 0.38 L/min, 95% CI − 0.91, 0.15).Conclusion: Our results demonstrated that the acute PM2.5 exposure exerted adverse impacts on children’s lung function, and children with severe asthma were more susceptible to the increase of PM2.5 exposure. The impacts of acute PM2.5 exposure varied across different countries.Keywords: particulate matter 2.5, PM2.5, children, peak expiratory flow, PEF, acute exposure, meta-analysis |
| first_indexed | 2024-04-09T13:16:51Z |
| format | Article |
| id | doaj.art-9378cafa0ff14d67b9eaa2d34525f28d |
| institution | Directory Open Access Journal |
| issn | 1178-6965 |
| language | English |
| last_indexed | 2024-04-09T13:16:51Z |
| publishDate | 2023-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj.art-9378cafa0ff14d67b9eaa2d34525f28d2023-05-11T18:59:32ZengDove Medical PressJournal of Asthma and Allergy1178-69652023-05-01Volume 1652954083638Effect of Acute PM2.5 Exposure on Lung Function in Children: A Systematic Review and Meta-AnalysisZhang YGuo ZZhang WLi QZhao YWang ZLuo ZYueming Zhang,1– 3 Ziyao Guo,1,2 Wen Zhang,3 Qinyuan Li,1,2 Yan Zhao,1,2 Zhili Wang,1,2 Zhengxiu Luo1,2 1Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, People’s Republic of China; 3Department of Respiratory, Xi’an Children’s Hospital, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Zhengxiu Luo, Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China, Email luozhengxiu816@hospital.cqmu.edu.cnObjective: The objective of this study was to conduct a systematic review and meta-analysis to identify the adverse effects of acute PM2.5 exposure on lung function in children.Design: Systematic review and meta-analysis. Setting, participants and measures: Eligible studies analyzing PM2.5 level and lung function in children were screened out. Effect estimates of PM2.5 measurements were quantified using random effect models. Heterogeneity was investigated with Q-test and I2 statistics. We also conducted meta-regression and sensitivity analysis to explore the sources of heterogeneity, such as different countries and asthmatic status. Subgroup analyses were conducted to determine the effects of acute PM2.5 exposure on children of different asthmatic status and in different countries.Results: A total of 11 studies with 4314 participants from Brazil, China and Japan were included finally. A 10 μg/m3 increase of PM2.5 was associated with a 1.74L/min (95% CI: − 2.68, − 0.90) decrease in peak expiratory flow (PEF). Since the asthmatic status and country could partly explain the heterogeneity, we conducted the subgroup analysis. Children with severe asthma were more susceptible to PM2.5 exposure (− 3.11 L/min per 10 μg/m3 increase, 95% CI − 4.54, − 1.67) than healthy children (− 1.61 L/min per 10 μg/m3 increase, 95% CI − 2.34, − 0.91). In the children of China, PEF decreased by 1.54 L/min (95% CI − 2.33, − 0.75) with a 10 μg/m3 increase in PM2.5 exposure. In the children of Japan, PEF decreased by 2.65 L/min (95% CI − 3.82, − 1.48) with a 10 μg/m3 increase of PM2.5 exposure. In contrast, no statistic association was found between every 10 μg/m3 increase of PM2.5 and lung function in children of Brazil (− 0.38 L/min, 95% CI − 0.91, 0.15).Conclusion: Our results demonstrated that the acute PM2.5 exposure exerted adverse impacts on children’s lung function, and children with severe asthma were more susceptible to the increase of PM2.5 exposure. The impacts of acute PM2.5 exposure varied across different countries.Keywords: particulate matter 2.5, PM2.5, children, peak expiratory flow, PEF, acute exposure, meta-analysishttps://www.dovepress.com/effect-of-acute-pm25-exposure-on-lung-function-in-children-a-systemati-peer-reviewed-fulltext-article-JAAparticulate matter (pm2.5)childrenlung functionacute exposuremeta-analysis |
| spellingShingle | Zhang Y Guo Z Zhang W Li Q Zhao Y Wang Z Luo Z Effect of Acute PM2.5 Exposure on Lung Function in Children: A Systematic Review and Meta-Analysis Journal of Asthma and Allergy particulate matter (pm2.5) children lung function acute exposure meta-analysis |
| title | Effect of Acute PM2.5 Exposure on Lung Function in Children: A Systematic Review and Meta-Analysis |
| title_full | Effect of Acute PM2.5 Exposure on Lung Function in Children: A Systematic Review and Meta-Analysis |
| title_fullStr | Effect of Acute PM2.5 Exposure on Lung Function in Children: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effect of Acute PM2.5 Exposure on Lung Function in Children: A Systematic Review and Meta-Analysis |
| title_short | Effect of Acute PM2.5 Exposure on Lung Function in Children: A Systematic Review and Meta-Analysis |
| title_sort | effect of acute pm2 5 exposure on lung function in children a systematic review and meta analysis |
| topic | particulate matter (pm2.5) children lung function acute exposure meta-analysis |
| url | https://www.dovepress.com/effect-of-acute-pm25-exposure-on-lung-function-in-children-a-systemati-peer-reviewed-fulltext-article-JAA |
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