Stoichiometry of multi-specific immune checkpoint RNA Abs for T cell activation and tumor inhibition using ultra-stable RNA nanoparticles

Stoichiometry of multi-specific immune checkpoint RNA Abs for T cell activation and tumor inhibition using ultra-stable RNA nanoparticles

Immunotherapy has become a revolutionary subject in cancer therapy during the past few years. Immune checkpoint-targeting antibodies (Abs) could boost anticancer immune responses. However, certain protein-based immunotherapies revealed side effects and unfavorable biodistribution, so effective non-p...

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Bibliographic Details
Main Authors: Dan Shu, Long Zhang, Xuefeng Bai, Jianhua Yu, Peixuan Guo
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
RNA nanotechnology
3WJ nano-scaffold
immunotherapy
multi-specific drugs
Ab-like RNA NPs
checkpoint
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000780

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