Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes
Abstract The emergence and rapid spread of antimicrobial resistance is of global public health concern. The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of an...
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| Language: | English |
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Wiley
2023-12-01
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| Series: | mLife |
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| Online Access: | https://doi.org/10.1002/mlf2.12101 |
| _version_ | 1797372381299212288 |
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| author | Yuhao Fu Qingyuan Dou Kornelia Smalla Yu Wang Timothy A. Johnson Kristian K. Brandt Zhi Mei Maoyuan Liao Syed A. Hashsham Andreas Schäffer Hauke Smidt Tong Zhang Hui Li Robert Stedtfeld Hongjie Sheng Benli Chai Marko Virta Xin Jiang Fang Wang Yong‐Guan Zhu James M. Tiedje |
| author_facet | Yuhao Fu Qingyuan Dou Kornelia Smalla Yu Wang Timothy A. Johnson Kristian K. Brandt Zhi Mei Maoyuan Liao Syed A. Hashsham Andreas Schäffer Hauke Smidt Tong Zhang Hui Li Robert Stedtfeld Hongjie Sheng Benli Chai Marko Virta Xin Jiang Fang Wang Yong‐Guan Zhu James M. Tiedje |
| author_sort | Yuhao Fu |
| collection | DOAJ |
| description | Abstract The emergence and rapid spread of antimicrobial resistance is of global public health concern. The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of antibiotic resistance genes (ARGs). In this review, we describe the reservoirs of gut ARGs and their dynamics in both animals and humans, use the One Health perspective to track the transmission of ARG‐containing bacteria between humans, animals, and the environment, and assess the impact of antimicrobial resistance on human health and socioeconomic development. The gut resistome can evolve in an environment subject to various selective pressures, including antibiotic administration and environmental and lifestyle factors (e.g., diet, age, gender, and living conditions), and interventions through probiotics. Strategies to reduce the abundance of clinically relevant antibiotic‐resistant bacteria and their resistance determinants in various environmental niches are needed to ensure the mitigation of acquired antibiotic resistance. With the help of effective measures taken at the national, local, personal, and intestinal management, it will also result in preventing or minimizing the spread of infectious diseases. This review aims to improve our understanding of the correlations between intestinal microbiota and antimicrobial resistance and provide a basis for the development of management strategies to mitigate the antimicrobial resistance crisis. |
| first_indexed | 2024-03-08T18:33:50Z |
| format | Article |
| id | doaj.art-937af0719be049469640f99e188805a3 |
| institution | Directory Open Access Journal |
| issn | 2770-100X |
| language | English |
| last_indexed | 2024-03-08T18:33:50Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | mLife |
| spelling | doaj.art-937af0719be049469640f99e188805a32023-12-29T16:36:04ZengWileymLife2770-100X2023-12-012435036410.1002/mlf2.12101Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomesYuhao Fu0Qingyuan Dou1Kornelia Smalla2Yu Wang3Timothy A. Johnson4Kristian K. Brandt5Zhi Mei6Maoyuan Liao7Syed A. Hashsham8Andreas Schäffer9Hauke Smidt10Tong Zhang11Hui Li12Robert Stedtfeld13Hongjie Sheng14Benli Chai15Marko Virta16Xin Jiang17Fang Wang18Yong‐Guan Zhu19James M. Tiedje20State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science Chinese Academy of Sciences Nanjing ChinaState Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science Chinese Academy of Sciences Nanjing ChinaJulius Kühn Institute (JKI) Federal Research Centre for Cultivated Plants Braunschweig GermanyState Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science Chinese Academy of Sciences Nanjing ChinaDepartment of Animal Sciences Purdue University West Lafayette Indiana USASection for Microbial Ecology and Biotechnology, Department of Plant and Environmental Sciences University of Copenhagen Frederiksberg C DenmarkState Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science Chinese Academy of Sciences Nanjing ChinaState Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science Chinese Academy of Sciences Nanjing ChinaDepartment of Plant, Soil and Microbial Sciences, Center for Microbial Ecology Michigan State University Michigan USAInstitute for Environmental Research RWTH Aachen University Aachen GermanyLaboratory of Microbiology Wageningen University & Research Wageningen The NetherlandsEnvironmental Microbiome Engineering and Biotechnology Laboratory, Center for Environmental Engineering Research, Department of Civil Engineering The University of Hong Kong Pokfulam Hong Kong ChinaDepartment of Plant, Soil and Microbial Sciences, Center for Microbial Ecology Michigan State University Michigan USADepartment of Civil and Environmental Engineering Michigan State University Michigan USAInstitute of Agricultural Resources and Environment Jiangsu Academy of Agricultural Sciences Nanjing ChinaDepartment of Plant, Soil and Microbial Sciences, Center for Microbial Ecology Michigan State University Michigan USADepartment of Microbiology University of Helsinki Helsinki FinlandState Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science Chinese Academy of Sciences Nanjing ChinaState Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science Chinese Academy of Sciences Nanjing ChinaUniversity of Chinese Academy of Sciences Beijing ChinaDepartment of Plant, Soil and Microbial Sciences, Center for Microbial Ecology Michigan State University Michigan USAAbstract The emergence and rapid spread of antimicrobial resistance is of global public health concern. The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of antibiotic resistance genes (ARGs). In this review, we describe the reservoirs of gut ARGs and their dynamics in both animals and humans, use the One Health perspective to track the transmission of ARG‐containing bacteria between humans, animals, and the environment, and assess the impact of antimicrobial resistance on human health and socioeconomic development. The gut resistome can evolve in an environment subject to various selective pressures, including antibiotic administration and environmental and lifestyle factors (e.g., diet, age, gender, and living conditions), and interventions through probiotics. Strategies to reduce the abundance of clinically relevant antibiotic‐resistant bacteria and their resistance determinants in various environmental niches are needed to ensure the mitigation of acquired antibiotic resistance. With the help of effective measures taken at the national, local, personal, and intestinal management, it will also result in preventing or minimizing the spread of infectious diseases. This review aims to improve our understanding of the correlations between intestinal microbiota and antimicrobial resistance and provide a basis for the development of management strategies to mitigate the antimicrobial resistance crisis.https://doi.org/10.1002/mlf2.12101antibioticantimicrobial resistancegut microbiotamodulatory strategiesOne Health |
| spellingShingle | Yuhao Fu Qingyuan Dou Kornelia Smalla Yu Wang Timothy A. Johnson Kristian K. Brandt Zhi Mei Maoyuan Liao Syed A. Hashsham Andreas Schäffer Hauke Smidt Tong Zhang Hui Li Robert Stedtfeld Hongjie Sheng Benli Chai Marko Virta Xin Jiang Fang Wang Yong‐Guan Zhu James M. Tiedje Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes mLife antibiotic antimicrobial resistance gut microbiota modulatory strategies One Health |
| title | Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes |
| title_full | Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes |
| title_fullStr | Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes |
| title_full_unstemmed | Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes |
| title_short | Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes |
| title_sort | gut microbiota research nexus one health relationship between human animal and environmental resistomes |
| topic | antibiotic antimicrobial resistance gut microbiota modulatory strategies One Health |
| url | https://doi.org/10.1002/mlf2.12101 |
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