Protective effects of chrysin in rats with ovarian torsion
The objective of this study is to assess the protective eff ect of chrysin (CH) against ovarian torsion-detorsion injury. Thirty-two female albino rats were divided into 4 groups as Control, Torsion/Detorsion (T/D), TD-CH, and CH. Ovarian torsion was done for 3 hours on TD and TD-CH groups and then...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kafkas University, Faculty of Veterinary Medicine
2021-06-01
|
| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://vetdergikafkas.org/pdf.php?id=2811 |
| _version_ | 1827922287484993536 |
|---|---|
| author | Deniz DİRİK Ahmet Ufuk KÖMÜROĞLU Volkan KOŞAL Yıldıray BAŞBUĞAN Uğur ÖZDEK Pınar KOLUSARI Ömer Faruk KELEŞ |
| author_facet | Deniz DİRİK Ahmet Ufuk KÖMÜROĞLU Volkan KOŞAL Yıldıray BAŞBUĞAN Uğur ÖZDEK Pınar KOLUSARI Ömer Faruk KELEŞ |
| author_sort | Deniz DİRİK |
| collection | DOAJ |
| description | The objective of this study is to assess the protective eff ect of chrysin (CH) against ovarian torsion-detorsion injury. Thirty-two female albino rats
were divided into 4 groups as Control, Torsion/Detorsion (T/D), TD-CH, and CH. Ovarian torsion was done for 3 hours on TD and TD-CH groups
and then detorsion was performed. 50 mg/kg of CH was administered to the TD-CH group via oral gavage half an hour before the detorsion.
Subsequently, 50 mg/kg of CH was administered via oral gavage to TD-CH and CH groups for 14 days. At the end of the experiment, blood
samples were collected and ovarian tissue were taken. SOD and GPx activities and GSH and 8-OHdG levels were studied in serum and ovarian
tissue. Also, IL-18, KIM-1, NGAL, Cys-C levels were studied in serum samples. GSH levels and GPx, SOD activities in both serum and ovarian tissue
were significantly lower in TD group compared to the control and TD-CH groups (P<0.05), whereas the 8-OHdG level was significantly higher
(P<0.05). Treatment with CH resulted in a decrease in 8-OHdG level and an increase in GSH level, GPx and SOD activities in both serum and
ovarian tissue in the TD-CH group compared to TD group (P<0.05). Chrysin could ameliorate ovarian injury. Essentially, this outcome is thanks to
the antioxidant, anti-infl ammatory, and antiapoptotic eff ects of chrysin. Furthermore, it also has significant eff ects on DNA oxidative damage. |
| first_indexed | 2024-03-13T04:39:30Z |
| format | Article |
| id | doaj.art-937af904abe44a538a38b46f21de00e5 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:39:30Z |
| publishDate | 2021-06-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-937af904abe44a538a38b46f21de00e52023-06-19T06:29:46ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512021-06-0127441742410.9775/kvfd.2021.253572811Protective effects of chrysin in rats with ovarian torsionDeniz DİRİK0Ahmet Ufuk KÖMÜROĞLU1Volkan KOŞAL2Yıldıray BAŞBUĞAN3Uğur ÖZDEK4Pınar KOLUSARI5Ömer Faruk KELEŞ6Van Yuzuncu Yil University, Faculty of Medical, Obstetrics and Gynecology Department, TR-65080 Van - TURKEYVan Yuzuncu Yil University, Health Service Vocational School of Higher Education, TR-65080 Van - TURKEYVan Yuzuncu Yil University, Faculty of Veterinary, Department of Artificial Insemination, TR-65080 Van - TURKEYVan Yuzuncu Yil University, Faculty of Veterinary, Internal Medicine, TR-65080 Van - TURKEYVan Yuzuncu Yil University, Health Service Vocational School of Higher Education, TR-65080 Van - TURKEYVan Educational and Research Hospital, Department of Anesthesiology and Reanimation, TR-65080 Van -TURKEYVan Yuzuncu Yil University, Faculty of Veterinary, Department of Pathology, TR-65080 Van - TURKEYThe objective of this study is to assess the protective eff ect of chrysin (CH) against ovarian torsion-detorsion injury. Thirty-two female albino rats were divided into 4 groups as Control, Torsion/Detorsion (T/D), TD-CH, and CH. Ovarian torsion was done for 3 hours on TD and TD-CH groups and then detorsion was performed. 50 mg/kg of CH was administered to the TD-CH group via oral gavage half an hour before the detorsion. Subsequently, 50 mg/kg of CH was administered via oral gavage to TD-CH and CH groups for 14 days. At the end of the experiment, blood samples were collected and ovarian tissue were taken. SOD and GPx activities and GSH and 8-OHdG levels were studied in serum and ovarian tissue. Also, IL-18, KIM-1, NGAL, Cys-C levels were studied in serum samples. GSH levels and GPx, SOD activities in both serum and ovarian tissue were significantly lower in TD group compared to the control and TD-CH groups (P<0.05), whereas the 8-OHdG level was significantly higher (P<0.05). Treatment with CH resulted in a decrease in 8-OHdG level and an increase in GSH level, GPx and SOD activities in both serum and ovarian tissue in the TD-CH group compared to TD group (P<0.05). Chrysin could ameliorate ovarian injury. Essentially, this outcome is thanks to the antioxidant, anti-infl ammatory, and antiapoptotic eff ects of chrysin. Furthermore, it also has significant eff ects on DNA oxidative damage.https://vetdergikafkas.org/pdf.php?id=2811ovary torsionchrysin8-ohdgantioxidant |
| spellingShingle | Deniz DİRİK Ahmet Ufuk KÖMÜROĞLU Volkan KOŞAL Yıldıray BAŞBUĞAN Uğur ÖZDEK Pınar KOLUSARI Ömer Faruk KELEŞ Protective effects of chrysin in rats with ovarian torsion Kafkas Universitesi Veteriner Fakültesi Dergisi ovary torsion chrysin 8-ohdg antioxidant |
| title | Protective effects of chrysin in rats with ovarian torsion |
| title_full | Protective effects of chrysin in rats with ovarian torsion |
| title_fullStr | Protective effects of chrysin in rats with ovarian torsion |
| title_full_unstemmed | Protective effects of chrysin in rats with ovarian torsion |
| title_short | Protective effects of chrysin in rats with ovarian torsion |
| title_sort | protective effects of chrysin in rats with ovarian torsion |
| topic | ovary torsion chrysin 8-ohdg antioxidant |
| url | https://vetdergikafkas.org/pdf.php?id=2811 |
| work_keys_str_mv | AT denizdirik protectiveeffectsofchrysininratswithovariantorsion AT ahmetufukkomuroglu protectiveeffectsofchrysininratswithovariantorsion AT volkankosal protectiveeffectsofchrysininratswithovariantorsion AT yıldıraybasbugan protectiveeffectsofchrysininratswithovariantorsion AT ugurozdek protectiveeffectsofchrysininratswithovariantorsion AT pınarkolusari protectiveeffectsofchrysininratswithovariantorsion AT omerfarukkeles protectiveeffectsofchrysininratswithovariantorsion |