Quality-by-Design-Based Development of n-Propyl-Gallate-Loaded Hyaluronic-Acid-Coated Liposomes for Intranasal Administration

Quality-by-Design-Based Development of n-Propyl-Gallate-Loaded Hyaluronic-Acid-Coated Liposomes for Intranasal Administration

The present study aimed to develop n-propyl gallate (PG)-encapsulated liposomes through a novel direct pouring method using the quality-by-design (QbD) approach. A further aim was to coat liposomes with hyaluronic acid (HA) to improve the stability of the formulation in nasal mucosa. The QbD method...

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Bibliographic Details
Main Authors: Fakhara Sabir, Gábor Katona, Edina Pallagi, Dorina Gabriella Dobó, Hussein Akel, Dániel Berkesi, Zoltán Kónya, Ildikó Csóka
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
intranasal delivery
hyaluronic acid
scavenging assay
risk assessment
in vitro release study
Online Access:https://www.mdpi.com/1420-3049/26/5/1429

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