Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration
Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health. Epigenetic gestational age acceleration, a discrepancy between clinical and DNA methylation-based gestational age, may underlie these...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2023.2165321 |
| _version_ | 1827811398533513216 |
|---|---|
| author | Irene Marques Susana Santos Giulietta S. Monasso Serena Fossati Martine Vrijheid Mark Nieuwenhuijsen Vincent W. V. Jaddoe Janine F. Felix |
| author_facet | Irene Marques Susana Santos Giulietta S. Monasso Serena Fossati Martine Vrijheid Mark Nieuwenhuijsen Vincent W. V. Jaddoe Janine F. Felix |
| author_sort | Irene Marques |
| collection | DOAJ |
| description | Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health. Epigenetic gestational age acceleration, a discrepancy between clinical and DNA methylation-based gestational age, may underlie these associations. In 1359 mother-newborn pairs from the population-based Generation R Study, we examined the associations of natural space exposure, defined as surrounding greenness, distance to major green and blue (water) space, and size of the blue space during pregnancy with offspring epigenetic gestational age acceleration. Natural space exposure was based on participants’ geocoded addresses, and epigenetic gestational age acceleration was calculated from cord blood DNA methylation using Bohlin’s and Knight’s epigenetic clocks. Sensitivity analyses were conducted in a subgroup of newborns with optimal pregnancy dating, based on last menstrual period. Surrounding greenness, measured in normalized difference vegetation index values, was intermediate (median 0.4, IQR 0.2), and 84% and 56% of the participants had a major green or blue space near their home address, respectively. We did not observe associations of natural space availability during pregnancy with offspring epigenetic gestational age acceleration. This could imply that epigenetic gestational age acceleration in cord blood does not underlie the effects of residential natural space availability in pregnancy on offspring health. Future studies could investigate whether residential natural space availability during pregnancy is associated with offspring differential DNA methylation at other CpGs than those included in the epigenetic gestational clocks. |
| first_indexed | 2024-03-11T23:05:40Z |
| format | Article |
| id | doaj.art-937cadbe20e343c3b2f0c445fdea06c3 |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:05:40Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-937cadbe20e343c3b2f0c445fdea06c32023-09-21T13:23:13ZengTaylor & Francis GroupEpigenetics1559-22941559-23082023-12-0118110.1080/15592294.2023.21653212165321Associations of green and blue space exposure in pregnancy with epigenetic gestational age accelerationIrene Marques0Susana Santos1Giulietta S. Monasso2Serena Fossati3Martine Vrijheid4Mark Nieuwenhuijsen5Vincent W. V. Jaddoe6Janine F. Felix7Erasmus MC, University Medical Center RotterdamErasmus MC, University Medical Center RotterdamErasmus MC, University Medical Center RotterdamISGlobal, Institute for Global HealthISGlobal, Institute for Global HealthISGlobal, Institute for Global HealthErasmus MC, University Medical Center RotterdamErasmus MC, University Medical Center RotterdamEarly life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health. Epigenetic gestational age acceleration, a discrepancy between clinical and DNA methylation-based gestational age, may underlie these associations. In 1359 mother-newborn pairs from the population-based Generation R Study, we examined the associations of natural space exposure, defined as surrounding greenness, distance to major green and blue (water) space, and size of the blue space during pregnancy with offspring epigenetic gestational age acceleration. Natural space exposure was based on participants’ geocoded addresses, and epigenetic gestational age acceleration was calculated from cord blood DNA methylation using Bohlin’s and Knight’s epigenetic clocks. Sensitivity analyses were conducted in a subgroup of newborns with optimal pregnancy dating, based on last menstrual period. Surrounding greenness, measured in normalized difference vegetation index values, was intermediate (median 0.4, IQR 0.2), and 84% and 56% of the participants had a major green or blue space near their home address, respectively. We did not observe associations of natural space availability during pregnancy with offspring epigenetic gestational age acceleration. This could imply that epigenetic gestational age acceleration in cord blood does not underlie the effects of residential natural space availability in pregnancy on offspring health. Future studies could investigate whether residential natural space availability during pregnancy is associated with offspring differential DNA methylation at other CpGs than those included in the epigenetic gestational clocks.http://dx.doi.org/10.1080/15592294.2023.2165321green spacesblue spacesenvironmental exposuresdna methylationageingepigenetic agegestational age accelerationpregnancycohort study |
| spellingShingle | Irene Marques Susana Santos Giulietta S. Monasso Serena Fossati Martine Vrijheid Mark Nieuwenhuijsen Vincent W. V. Jaddoe Janine F. Felix Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration Epigenetics green spaces blue spaces environmental exposures dna methylation ageing epigenetic age gestational age acceleration pregnancy cohort study |
| title | Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration |
| title_full | Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration |
| title_fullStr | Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration |
| title_full_unstemmed | Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration |
| title_short | Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration |
| title_sort | associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration |
| topic | green spaces blue spaces environmental exposures dna methylation ageing epigenetic age gestational age acceleration pregnancy cohort study |
| url | http://dx.doi.org/10.1080/15592294.2023.2165321 |
| work_keys_str_mv | AT irenemarques associationsofgreenandbluespaceexposureinpregnancywithepigeneticgestationalageacceleration AT susanasantos associationsofgreenandbluespaceexposureinpregnancywithepigeneticgestationalageacceleration AT giuliettasmonasso associationsofgreenandbluespaceexposureinpregnancywithepigeneticgestationalageacceleration AT serenafossati associationsofgreenandbluespaceexposureinpregnancywithepigeneticgestationalageacceleration AT martinevrijheid associationsofgreenandbluespaceexposureinpregnancywithepigeneticgestationalageacceleration AT marknieuwenhuijsen associationsofgreenandbluespaceexposureinpregnancywithepigeneticgestationalageacceleration AT vincentwvjaddoe associationsofgreenandbluespaceexposureinpregnancywithepigeneticgestationalageacceleration AT janineffelix associationsofgreenandbluespaceexposureinpregnancywithepigeneticgestationalageacceleration |