Anti-Candida and Antibiofilm Activity of Selected Lamiaceae Essential Oils
Background: Candidiasis is a common oral and vaginal infection. Some papers have presented that the essential oils of Lamiaceae plants can have antifungal activity. This study aimed to investigate the activity of 7 essential oils of the Lamiaceae family with known phytochemical compositions against...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-02-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/28/2/10.31083/j.fbl2802028 |
| _version_ | 1811160699459600384 |
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| author | Tomasz M. Karpiński Marcin Ożarowski Agnieszka Seremak-Mrozikiewicz Hubert Wolski |
| author_facet | Tomasz M. Karpiński Marcin Ożarowski Agnieszka Seremak-Mrozikiewicz Hubert Wolski |
| author_sort | Tomasz M. Karpiński |
| collection | DOAJ |
| description | Background: Candidiasis is a common oral and vaginal infection. Some papers have presented that the essential oils of Lamiaceae plants can have antifungal activity. This study aimed to investigate the activity of 7 essential oils of the Lamiaceae family with known phytochemical compositions against Candida fungi. Methods: Forty-four strains belonging to six species were tested: C. albicans, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis, and C. tropicalis. During this investigation, the following methods were used: determination of the minimal inhibitory concentrations (MICs), biofilm inhibition studies, and in silicotoxicity tests. Results: Essential oils of lemon balm (Melissa officinalis) and oregano (Origanum vulgare) showed the best anti-Candida activity, with MIC values below 3.125 mg/mL. Lavender (Lavandula stoechas), mint (Mentha × piperita), rosemary (Rosmarinus officinalis), and thyme (Thymus vulgaris) essential oils were also very active (0.39 to 6.25 or 12.5 mg/mL). Sage (Salvia officinalis) essential oil presented the lowest activity, with MIC values ranging from 3.125 to 100 mg/mL. In an antibiofilm study using MIC values, oregano and thyme essential oils showed the greatest effect, followed by lavender, mint, and rosemary oils. The weakest antibiofilm activity was observed with the lemon balm and sage oils. In silico toxicity research suggests that most of main compounds of Lamiaceae essential oils probably do not exhibit carcinogenicity, mutagenicity, or cytotoxicity. Conclusions: The obtained results showed that Lamiaceae essential oils have anti-Candida and antibiofilm activity. Further research is required to confirm the safety and efficacy of essential oils in the topical treatment of candidiasis. |
| first_indexed | 2024-04-10T06:01:50Z |
| format | Article |
| id | doaj.art-937de51e24a24c1ca0a8dd158112c812 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-04-10T06:01:50Z |
| publishDate | 2023-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-937de51e24a24c1ca0a8dd158112c8122023-03-03T08:24:30ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-02-012822810.31083/j.fbl2802028S2768-6701(23)00777-3Anti-Candida and Antibiofilm Activity of Selected Lamiaceae Essential OilsTomasz M. Karpiński0Marcin Ożarowski1Agnieszka Seremak-Mrozikiewicz2Hubert Wolski3Chair and Department of Medical Microbiology, Poznań University of Medical Sciences, 60-806 Poznań, PolandDepartment of Biotechnology, Institute of Natural Fibres and Medicinal Plants – National Research Institute, 60-630 Poznań, PolandDivision of Perinatology and Women's Disease, Poznań University of Medical Sciences, 60-535 Poznań, PolandDivision of Perinatology and Women's Disease, Poznań University of Medical Sciences, 60-535 Poznań, PolandBackground: Candidiasis is a common oral and vaginal infection. Some papers have presented that the essential oils of Lamiaceae plants can have antifungal activity. This study aimed to investigate the activity of 7 essential oils of the Lamiaceae family with known phytochemical compositions against Candida fungi. Methods: Forty-four strains belonging to six species were tested: C. albicans, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis, and C. tropicalis. During this investigation, the following methods were used: determination of the minimal inhibitory concentrations (MICs), biofilm inhibition studies, and in silicotoxicity tests. Results: Essential oils of lemon balm (Melissa officinalis) and oregano (Origanum vulgare) showed the best anti-Candida activity, with MIC values below 3.125 mg/mL. Lavender (Lavandula stoechas), mint (Mentha × piperita), rosemary (Rosmarinus officinalis), and thyme (Thymus vulgaris) essential oils were also very active (0.39 to 6.25 or 12.5 mg/mL). Sage (Salvia officinalis) essential oil presented the lowest activity, with MIC values ranging from 3.125 to 100 mg/mL. In an antibiofilm study using MIC values, oregano and thyme essential oils showed the greatest effect, followed by lavender, mint, and rosemary oils. The weakest antibiofilm activity was observed with the lemon balm and sage oils. In silico toxicity research suggests that most of main compounds of Lamiaceae essential oils probably do not exhibit carcinogenicity, mutagenicity, or cytotoxicity. Conclusions: The obtained results showed that Lamiaceae essential oils have anti-Candida and antibiofilm activity. Further research is required to confirm the safety and efficacy of essential oils in the topical treatment of candidiasis.https://www.imrpress.com/journal/FBL/28/2/10.31083/j.fbl2802028essential oilsantifungalantibiofilmlamiaceaephytocompoundsdrug sensitivityin silicotoxicity |
| spellingShingle | Tomasz M. Karpiński Marcin Ożarowski Agnieszka Seremak-Mrozikiewicz Hubert Wolski Anti-Candida and Antibiofilm Activity of Selected Lamiaceae Essential Oils Frontiers in Bioscience-Landmark essential oils antifungal antibiofilm lamiaceae phytocompounds drug sensitivity in silico toxicity |
| title | Anti-Candida and Antibiofilm Activity of Selected Lamiaceae Essential Oils |
| title_full | Anti-Candida and Antibiofilm Activity of Selected Lamiaceae Essential Oils |
| title_fullStr | Anti-Candida and Antibiofilm Activity of Selected Lamiaceae Essential Oils |
| title_full_unstemmed | Anti-Candida and Antibiofilm Activity of Selected Lamiaceae Essential Oils |
| title_short | Anti-Candida and Antibiofilm Activity of Selected Lamiaceae Essential Oils |
| title_sort | anti candida and antibiofilm activity of selected lamiaceae essential oils |
| topic | essential oils antifungal antibiofilm lamiaceae phytocompounds drug sensitivity in silico toxicity |
| url | https://www.imrpress.com/journal/FBL/28/2/10.31083/j.fbl2802028 |
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