Highly Polymorphic Materials and Dissolution Behaviour: The Peculiar Case of Rifaximin

Highly Polymorphic Materials and Dissolution Behaviour: The Peculiar Case of Rifaximin

Rifaximin is a locally acting antibiotic practically insoluble in water. It presents several crystal phases characterized by different degrees of hydration. The aim of this work is to investigate the dissolution behaviour of rifaximin α, β, and amorphous forms in relation to their relative thermodyn...

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Bibliographic Details
Main Authors: Annalisa Bianchera, Marino Nebuloni, Nicola Colombo, Davide Pirola, Ruggero Bettini
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
rifaximin
dissolution
pseudopolymorphs
supersaturation
kinetic solubility
Online Access:https://www.mdpi.com/1999-4923/15/1/53

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