The unique role of the frontal aslant tract in speech and language processing
The frontal aslant tract (FAT) is a recently described intralobar tract that connects the superior and inferior frontal gyri. The FAT has been implicated in various speech and language processes and disorders, including motor speech impairments, stuttering disorders, opercular syndrome, and verbal f...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222000857 |
| _version_ | 1818008813961216000 |
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| author | Allison J. Zhong Juliana V. Baldo Nina F. Dronkers Maria V. Ivanova |
| author_facet | Allison J. Zhong Juliana V. Baldo Nina F. Dronkers Maria V. Ivanova |
| author_sort | Allison J. Zhong |
| collection | DOAJ |
| description | The frontal aslant tract (FAT) is a recently described intralobar tract that connects the superior and inferior frontal gyri. The FAT has been implicated in various speech and language processes and disorders, including motor speech impairments, stuttering disorders, opercular syndrome, and verbal fluency, but the specific function(s) of the FAT have yet to be elucidated. In the current study, we aimed to address this knowledge gap by investigating the underlying role that the FAT plays in motor aspects of speech and language abilities in post-stroke aphasia. Our goals were three-fold: 1) To identify which specific motor speech or language abilities are impacted by FAT damage by utilizing a powerful imaging analysis method, High Angular Resolution Diffusion Imaging (HARDI) tractography; 2) To determine whether damage to the FAT is associated with functional deficits on a range of motor speech and language tasks even when accounting for cortical damage to adjacent cortical regions; and 3) To explore whether subsections of the FAT (lateral and medial segments) play distinct roles in motor speech performance. We hypothesized that damage to the FAT would be most strongly associated with motor speech performance in comparison to language tasks. We analyzed HARDI data from thirty-three people with aphasia (PWA) with a history of chronic left hemisphere stroke. FAT metrics were related to scores on several speech and language tests: the Motor Speech Evaluation (MSE), the Western Aphasia Battery (WAB) aphasia quotient and subtests, and the Boston Naming Test (BNT). Our results indicated that the integrity of the FAT was strongly associated with the MSE as predicted, and weakly negatively associated with WAB subtest scores including Naming, Comprehension, and Repetition, likely reflecting the fact that performance on these WAB subtests is associated with damage to posterior areas of the brain that are unlikely to be damaged with a frontal lesion. We also performed hierarchical stepwise regressions to predict language function based on FAT properties and lesion load to surrounding cortical areas. After accounting for the contributions of the inferior frontal gyrus, the ventral precentral gyrus, and the superior precentral gyrus of the insula, the FAT still remained a significant predictor of MSE apraxia scores. Our results further showed that the medial and lateral subsections of the FAT did not appear to play distinct roles but rather may indicate normal anatomical variations of the FAT. Overall, current results indicate that the FAT plays a specific and unique role in motor speech. These results further our understanding of the role that white matter tracts play in speech and language. |
| first_indexed | 2024-04-14T05:34:55Z |
| format | Article |
| id | doaj.art-937f93af14db401096ccf0365ff7ec2e |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-14T05:34:55Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-937f93af14db401096ccf0365ff7ec2e2022-12-22T02:09:42ZengElsevierNeuroImage: Clinical2213-15822022-01-0134103020The unique role of the frontal aslant tract in speech and language processingAllison J. Zhong0Juliana V. Baldo1Nina F. Dronkers2Maria V. Ivanova3School of Medicine, New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY 10595, USA; Center for Language, Imaging, Mind & Brain, VA Northern California Healthcare System, Martinez, CA, USACenter for Language, Imaging, Mind & Brain, VA Northern California Healthcare System, Martinez, CA, USAAphasia Recovery Lab, Department of Psychology, University of California, Berkeley, CA, USA; Department of Neurology, University of California, Davis, CA, USACenter for Language, Imaging, Mind & Brain, VA Northern California Healthcare System, Martinez, CA, USA; Aphasia Recovery Lab, Department of Psychology, University of California, Berkeley, CA, USA; Corresponding author at: Aphasia Recovery Lab, Department of Psychology, 210 Barker Hall, UC Berkeley, Berkeley, CA 94720, USA.The frontal aslant tract (FAT) is a recently described intralobar tract that connects the superior and inferior frontal gyri. The FAT has been implicated in various speech and language processes and disorders, including motor speech impairments, stuttering disorders, opercular syndrome, and verbal fluency, but the specific function(s) of the FAT have yet to be elucidated. In the current study, we aimed to address this knowledge gap by investigating the underlying role that the FAT plays in motor aspects of speech and language abilities in post-stroke aphasia. Our goals were three-fold: 1) To identify which specific motor speech or language abilities are impacted by FAT damage by utilizing a powerful imaging analysis method, High Angular Resolution Diffusion Imaging (HARDI) tractography; 2) To determine whether damage to the FAT is associated with functional deficits on a range of motor speech and language tasks even when accounting for cortical damage to adjacent cortical regions; and 3) To explore whether subsections of the FAT (lateral and medial segments) play distinct roles in motor speech performance. We hypothesized that damage to the FAT would be most strongly associated with motor speech performance in comparison to language tasks. We analyzed HARDI data from thirty-three people with aphasia (PWA) with a history of chronic left hemisphere stroke. FAT metrics were related to scores on several speech and language tests: the Motor Speech Evaluation (MSE), the Western Aphasia Battery (WAB) aphasia quotient and subtests, and the Boston Naming Test (BNT). Our results indicated that the integrity of the FAT was strongly associated with the MSE as predicted, and weakly negatively associated with WAB subtest scores including Naming, Comprehension, and Repetition, likely reflecting the fact that performance on these WAB subtests is associated with damage to posterior areas of the brain that are unlikely to be damaged with a frontal lesion. We also performed hierarchical stepwise regressions to predict language function based on FAT properties and lesion load to surrounding cortical areas. After accounting for the contributions of the inferior frontal gyrus, the ventral precentral gyrus, and the superior precentral gyrus of the insula, the FAT still remained a significant predictor of MSE apraxia scores. Our results further showed that the medial and lateral subsections of the FAT did not appear to play distinct roles but rather may indicate normal anatomical variations of the FAT. Overall, current results indicate that the FAT plays a specific and unique role in motor speech. These results further our understanding of the role that white matter tracts play in speech and language.http://www.sciencedirect.com/science/article/pii/S2213158222000857Frontal aslant tractDiffusion imagingTractographyAphasiaApraxia of speechStroke |
| spellingShingle | Allison J. Zhong Juliana V. Baldo Nina F. Dronkers Maria V. Ivanova The unique role of the frontal aslant tract in speech and language processing NeuroImage: Clinical Frontal aslant tract Diffusion imaging Tractography Aphasia Apraxia of speech Stroke |
| title | The unique role of the frontal aslant tract in speech and language processing |
| title_full | The unique role of the frontal aslant tract in speech and language processing |
| title_fullStr | The unique role of the frontal aslant tract in speech and language processing |
| title_full_unstemmed | The unique role of the frontal aslant tract in speech and language processing |
| title_short | The unique role of the frontal aslant tract in speech and language processing |
| title_sort | unique role of the frontal aslant tract in speech and language processing |
| topic | Frontal aslant tract Diffusion imaging Tractography Aphasia Apraxia of speech Stroke |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222000857 |
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