VHH-Based Bispecific Antibodies Targeting Cytokine Production

VHH-Based Bispecific Antibodies Targeting Cytokine Production

Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because proinflammatory cytokines possess non-redundant protective and immunoregulatory functions, their systemic neutralization carries the potential for...

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Bibliographic Details
Main Authors: Maxim A. Nosenko, Kamar-Sulu N. Atretkhany, Vladislav V. Mokhonov, Grigory A. Efimov, Andrey A. Kruglov, Sergei V. Tillib, Marina S. Drutskaya, Sergei A. Nedospasov
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
TNF
IL-6
macrophages
single-chain antibodies
VHH
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01073/full

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