Stereotactic Body Radiotherapy for Lung Lesions using Multiple Phase 3D-CT Based on the Analysis of Radiobiological Parameters
Introduction: Planning target volume (PTV) is generated from internal treatment volume (ITV) using four-dimensional computed tomography (4D-CT) for enhanced therapeutic gain in the stereotactic body radiotherapy for lung lesions (SBRT-Lung). This study aimed to propose a strategy to generate ITV on...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2019-07-01
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| Series: | Iranian Journal of Medical Physics |
| Subjects: | |
| Online Access: | http://ijmp.mums.ac.ir/article_11902_248b4b33cf56f478e50bed2759677110.pdf |
| Summary: | Introduction: Planning target volume (PTV) is generated from internal treatment volume (ITV) using four-dimensional computed tomography (4D-CT) for enhanced therapeutic gain in the stereotactic body radiotherapy for lung lesions (SBRT-Lung). This study aimed to propose a strategy to generate ITV on multiple-phase 3D-CT and enhance therapeutic gain in SBRT-Lung.
Material and Methods: This study was conducted on 6 peripherally located and 5 centrally located lung lesions suitable for SBRT. The PTV was delineated based on 3D-CT datasets acquired at three different phases of respiratory motion. The prescribed dose of 50 Gy in 5 fractions was delivered using RapidArc technique. The therapeutic-gain was compared based on tumor control probability (TCP) and normal tissue complication probability (NTCP) against a multicenter trial, which uses single-phase 3D-CT for PTV delineation. The TCP and NTCP were calculated by Poisson’s linear-quadratic and Lyman-Kutcher-Burman models, respectively.
Results: Regarding the multicentre trial, the PTVs were maximally reduced to 42% and 57% among the 6 peripherally and 5 centrally located lung lesions, respectively. In peripheral lung lesions, TCP was significantly enhanced to 0.6% for long-term (>5years) local control (P |
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| ISSN: | 2345-3672 2345-3672 |