Oral Oxycodone Compared With Intravenous Morphine Sulfate for Pain Management of Isolated Limb Trauma; a Randomized Clinical Trial
Introduction:Â Appropriate pain relief enhances patient satisfaction and reduces patient anxiety. This study aimed to compare oral oxycodone with intravenous (IV) morphine sulfate (MS) in pain management of acute limb trauma. Method:Â In this randomized double-blind clinical trial, patients over 14...
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| Format: | Article |
| Language: | English |
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Shahid Beheshti University of Medical Sciences
2018-08-01
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| Series: | Archives of Academic Emergency Medicine |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/137 |
| _version_ | 1828351959734681600 |
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| author | Parisa Eizadi Mohammad Jalili Ahmadreza Dehpour |
| author_facet | Parisa Eizadi Mohammad Jalili Ahmadreza Dehpour |
| author_sort | Parisa Eizadi |
| collection | DOAJ |
| description | Introduction:Â Appropriate pain relief enhances patient satisfaction and reduces patient anxiety. This study aimed to compare oral oxycodone with intravenous (IV) morphine sulfate (MS) in pain management of acute limb trauma.
Method:Â In this randomized double-blind clinical trial, patients over 14 years old, with acute isolated limb trauma were randomized to receive either 5mg IV MS or 5 mg oral oxycodone. Pain intensity and adverse effects of medications were recorded 0, 30 and 60 minutes after drug administration and compared between the groups.
Result:Â 58 patients were studied. Pain intensity was similar between the two studied groups at 30 minutes (P = 0.834) and 60 minutes (P = 0.880) after drug administration. Furthermore, there was no significant difference between the two groups regarding decrease in pain within the defined time interval. Drowsiness was reported more frequently in MS group after 30 minutes (p = 0.006). Patients in MS group asked for more rescue analgesia. Other adverse effects were similar in both groups.
Conclusion:Â Oral oxycodone is as effective as IV morphine sulfate in treatment of acute musculoskeletal pain following blunt limb trauma. |
| first_indexed | 2024-04-14T01:47:07Z |
| format | Article |
| id | doaj.art-93821a2995824f36997abc9d79ec905d |
| institution | Directory Open Access Journal |
| issn | 2645-4904 |
| language | English |
| last_indexed | 2024-04-14T01:47:07Z |
| publishDate | 2018-08-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Archives of Academic Emergency Medicine |
| spelling | doaj.art-93821a2995824f36997abc9d79ec905d2022-12-22T02:19:30ZengShahid Beheshti University of Medical SciencesArchives of Academic Emergency Medicine2645-49042018-08-016110.22037/aaem.v6i1.137Oral Oxycodone Compared With Intravenous Morphine Sulfate for Pain Management of Isolated Limb Trauma; a Randomized Clinical TrialParisa Eizadi0Mohammad Jalili1Ahmadreza Dehpour2Department of Emergency Medicine, Tehran University of Medical SciencesDepartment of Emergency Medicine, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran.Introduction:Â Appropriate pain relief enhances patient satisfaction and reduces patient anxiety. This study aimed to compare oral oxycodone with intravenous (IV) morphine sulfate (MS) in pain management of acute limb trauma. Method:Â In this randomized double-blind clinical trial, patients over 14 years old, with acute isolated limb trauma were randomized to receive either 5mg IV MS or 5 mg oral oxycodone. Pain intensity and adverse effects of medications were recorded 0, 30 and 60 minutes after drug administration and compared between the groups. Result:Â 58 patients were studied. Pain intensity was similar between the two studied groups at 30 minutes (P = 0.834) and 60 minutes (P = 0.880) after drug administration. Furthermore, there was no significant difference between the two groups regarding decrease in pain within the defined time interval. Drowsiness was reported more frequently in MS group after 30 minutes (p = 0.006). Patients in MS group asked for more rescue analgesia. Other adverse effects were similar in both groups. Conclusion:Â Oral oxycodone is as effective as IV morphine sulfate in treatment of acute musculoskeletal pain following blunt limb trauma.https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/137oxycodonemorphinewounds and injuriesacute pain |
| spellingShingle | Parisa Eizadi Mohammad Jalili Ahmadreza Dehpour Oral Oxycodone Compared With Intravenous Morphine Sulfate for Pain Management of Isolated Limb Trauma; a Randomized Clinical Trial Archives of Academic Emergency Medicine oxycodone morphine wounds and injuries acute pain |
| title | Oral Oxycodone Compared With Intravenous Morphine Sulfate for Pain Management of Isolated Limb Trauma; a Randomized Clinical Trial |
| title_full | Oral Oxycodone Compared With Intravenous Morphine Sulfate for Pain Management of Isolated Limb Trauma; a Randomized Clinical Trial |
| title_fullStr | Oral Oxycodone Compared With Intravenous Morphine Sulfate for Pain Management of Isolated Limb Trauma; a Randomized Clinical Trial |
| title_full_unstemmed | Oral Oxycodone Compared With Intravenous Morphine Sulfate for Pain Management of Isolated Limb Trauma; a Randomized Clinical Trial |
| title_short | Oral Oxycodone Compared With Intravenous Morphine Sulfate for Pain Management of Isolated Limb Trauma; a Randomized Clinical Trial |
| title_sort | oral oxycodone compared with intravenous morphine sulfate for pain management of isolated limb trauma a randomized clinical trial |
| topic | oxycodone morphine wounds and injuries acute pain |
| url | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/137 |
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