Association of T-wave electrocardiogram changes and type 2 diabetes: a cross-sectional sub-analysis of the MASHAD cohort population using the Minnesota coding system
Abstract Background Type 2 Diabetes Mellitus (T2DM) has become a major health concern with an increasing prevalence and is now one of the leading attributable causes of death globally. T2DM and cardiovascular disease are strongly associated and T2DM is an important independent risk factor for ischem...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03649-2 |
| _version_ | 1797355995920334848 |
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| author | Sara Soflaei Saffar Eisa Nazar Toktam Sahranavard Farzad Fayedeh AmirAli Moodi Ghalibaf Mahmoud Ebrahimi Hedieh Alimi Bahram Shahri Azadeh Izadi-Moud Gordon A. Ferns Alireza Ghodsi Saeed Mehrabi Milad Tarhimi Habibollah Esmaily Mohsen Moohebati Majid Ghayour-Mobarhan |
| author_facet | Sara Soflaei Saffar Eisa Nazar Toktam Sahranavard Farzad Fayedeh AmirAli Moodi Ghalibaf Mahmoud Ebrahimi Hedieh Alimi Bahram Shahri Azadeh Izadi-Moud Gordon A. Ferns Alireza Ghodsi Saeed Mehrabi Milad Tarhimi Habibollah Esmaily Mohsen Moohebati Majid Ghayour-Mobarhan |
| author_sort | Sara Soflaei Saffar |
| collection | DOAJ |
| description | Abstract Background Type 2 Diabetes Mellitus (T2DM) has become a major health concern with an increasing prevalence and is now one of the leading attributable causes of death globally. T2DM and cardiovascular disease are strongly associated and T2DM is an important independent risk factor for ischemic heart disease. T-wave abnormalities (TWA) on electrocardiogram (ECG) can indicate several pathologies including ischemia. In this study, we aimed to investigate the association between T2DM and T-wave changes using the Minnesota coding system. Methods A cross-sectional study was conducted on the MASHAD cohort study population. All participants of the cohort population were enrolled in the study. 12-lead ECG and Minnesota coding system (codes 5–1 to 5–4) were utilized for T-wave observation and interpretation. Regression models were used for the final evaluation with a level of significance being considered at p < 0.05. Results A total of 9035 participants aged 35–65 years old were included in the study, of whom 1273 were diabetic. The prevalence of code 5–2, 5–3, major and minor TWA were significantly higher in diabetics (p < 0.05). However, following adjustment for age, gender, and hypertension, the presence of TWAs was not significantly associated with T2DM (p > 0.05). Hypertension, age, and body mass index were significantly associated with T2DM (p < 0.05). Conclusions Although some T-wave abnormalities were more frequent in diabetics, they were not statistically associated with the presence of T2DM in our study. |
| first_indexed | 2024-03-08T14:19:19Z |
| format | Article |
| id | doaj.art-93835c48e8cc44ab88a8510e8c5601f3 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-08T14:19:19Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-93835c48e8cc44ab88a8510e8c5601f32024-01-14T12:11:16ZengBMCBMC Cardiovascular Disorders1471-22612024-01-0124111010.1186/s12872-023-03649-2Association of T-wave electrocardiogram changes and type 2 diabetes: a cross-sectional sub-analysis of the MASHAD cohort population using the Minnesota coding systemSara Soflaei Saffar0Eisa Nazar1Toktam Sahranavard2Farzad Fayedeh3AmirAli Moodi Ghalibaf4Mahmoud Ebrahimi5Hedieh Alimi6Bahram Shahri7Azadeh Izadi-Moud8Gordon A. Ferns9Alireza Ghodsi10Saeed Mehrabi11Milad Tarhimi12Habibollah Esmaily13Mohsen Moohebati14Majid Ghayour-Mobarhan15International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical SciencesOrthopedic Research Center, Mazandaran University of Medical SciencesInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical SciencesStudent Research Committee, Birjand University of Medical SciencesStudent Research Committee, Birjand University of Medical SciencesVascular and Endovascular Research Center, Faculty of Medicine, Mashhad University of Medical SciencesVascular and Endovascular Research Center, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Cardiology, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Cardiology, Faculty of Medicine, Mashhad University of Medical SciencesBrighton and Sussex Medical School, Division of Medical EducationInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical SciencesDepartment of Cardiology, Faculty of Medicine, Gonabad University of Medical SciencesDepartment of Cardiology, Faculty of Medicine, Gonabad University of Medical SciencesDepartment of Biostatistics, School of Health, Mashhad University of Medical SciencesVascular and Endovascular Research Center, Faculty of Medicine, Mashhad University of Medical SciencesInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical SciencesAbstract Background Type 2 Diabetes Mellitus (T2DM) has become a major health concern with an increasing prevalence and is now one of the leading attributable causes of death globally. T2DM and cardiovascular disease are strongly associated and T2DM is an important independent risk factor for ischemic heart disease. T-wave abnormalities (TWA) on electrocardiogram (ECG) can indicate several pathologies including ischemia. In this study, we aimed to investigate the association between T2DM and T-wave changes using the Minnesota coding system. Methods A cross-sectional study was conducted on the MASHAD cohort study population. All participants of the cohort population were enrolled in the study. 12-lead ECG and Minnesota coding system (codes 5–1 to 5–4) were utilized for T-wave observation and interpretation. Regression models were used for the final evaluation with a level of significance being considered at p < 0.05. Results A total of 9035 participants aged 35–65 years old were included in the study, of whom 1273 were diabetic. The prevalence of code 5–2, 5–3, major and minor TWA were significantly higher in diabetics (p < 0.05). However, following adjustment for age, gender, and hypertension, the presence of TWAs was not significantly associated with T2DM (p > 0.05). Hypertension, age, and body mass index were significantly associated with T2DM (p < 0.05). Conclusions Although some T-wave abnormalities were more frequent in diabetics, they were not statistically associated with the presence of T2DM in our study.https://doi.org/10.1186/s12872-023-03649-2ElectrocardiogramType 2 diabetes mellitusT-wave |
| spellingShingle | Sara Soflaei Saffar Eisa Nazar Toktam Sahranavard Farzad Fayedeh AmirAli Moodi Ghalibaf Mahmoud Ebrahimi Hedieh Alimi Bahram Shahri Azadeh Izadi-Moud Gordon A. Ferns Alireza Ghodsi Saeed Mehrabi Milad Tarhimi Habibollah Esmaily Mohsen Moohebati Majid Ghayour-Mobarhan Association of T-wave electrocardiogram changes and type 2 diabetes: a cross-sectional sub-analysis of the MASHAD cohort population using the Minnesota coding system BMC Cardiovascular Disorders Electrocardiogram Type 2 diabetes mellitus T-wave |
| title | Association of T-wave electrocardiogram changes and type 2 diabetes: a cross-sectional sub-analysis of the MASHAD cohort population using the Minnesota coding system |
| title_full | Association of T-wave electrocardiogram changes and type 2 diabetes: a cross-sectional sub-analysis of the MASHAD cohort population using the Minnesota coding system |
| title_fullStr | Association of T-wave electrocardiogram changes and type 2 diabetes: a cross-sectional sub-analysis of the MASHAD cohort population using the Minnesota coding system |
| title_full_unstemmed | Association of T-wave electrocardiogram changes and type 2 diabetes: a cross-sectional sub-analysis of the MASHAD cohort population using the Minnesota coding system |
| title_short | Association of T-wave electrocardiogram changes and type 2 diabetes: a cross-sectional sub-analysis of the MASHAD cohort population using the Minnesota coding system |
| title_sort | association of t wave electrocardiogram changes and type 2 diabetes a cross sectional sub analysis of the mashad cohort population using the minnesota coding system |
| topic | Electrocardiogram Type 2 diabetes mellitus T-wave |
| url | https://doi.org/10.1186/s12872-023-03649-2 |
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