Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease
This systematic review with meta-analysis evaluated the antioxidant effect of lycopene as an adjuvant treatment for periodontal disease. PubMed, EMBASE and Web of Science databases were consulted. According to the PICOs strategy, inclusion criteria were established for intervention studies Randomize...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1309851/full |
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| author | Nansi López-Valverde Antonio López-Valverde Bruno Macedo de Sousa José Antonio Blanco Rueda |
| author_facet | Nansi López-Valverde Antonio López-Valverde Bruno Macedo de Sousa José Antonio Blanco Rueda |
| author_sort | Nansi López-Valverde |
| collection | DOAJ |
| description | This systematic review with meta-analysis evaluated the antioxidant effect of lycopene as an adjuvant treatment for periodontal disease. PubMed, EMBASE and Web of Science databases were consulted. According to the PICOs strategy, inclusion criteria were established for intervention studies Randomized Controlled Trials in Probing depth subjects (participants) treated with conventional treatment and lycopene (intervention) compared to patients treated with conventional treatment (control) in which periodontal response to treatment (outcome) was assessed. The risk of bias for randomized studies was assessed using the Cochrane Risk of Bias Tool. The methodological quality of the studies included in the meta-analysis was measured using the Jadad scale. Quantitative data were analyzed using six random-effects meta-analyses, taking into account periodontal parameters: Probing Pocket Depth, Clinical Attachment Loss, Bleeding on Probing, Plaque Index, Uric Acid and Gingival Index. Six further meta-analyses were performed, according to the follow-up of the studies (short-, medium- and long-term). Of the 339 studies identified, only 7 met the eligibility criteria. The meta-analysis of the studies according to the parameters evaluated only obtained statistical significance in the assessment of plaque index (p = 0.003). Regarding follow-up periods, PPD was significant (p = 0.03) in the short term. bleeding on probing estimates were significant in the short and medium term (p = 0.008 and p = 0.03, respectively), IP was significant in the short and medium term (p = 0.0003 and p = 0.01, respectively) and gingival index in the short and medium term (p = 0.002 and p = 0.02, respectively). Heterogeneity was high (I2 >50%) in all assessments, except for Clinical Attachment Loss (I2 = 16.7%). The results demonstrate that antioxidant treatment with lycopene could be useful as an adjunctive treatment for periodontal disease. |
| first_indexed | 2024-03-08T04:40:03Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-08T04:40:03Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-93865f207c304702951fd23d78bb2de92024-02-08T12:51:22ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-01-011110.3389/fbioe.2023.13098511309851Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal diseaseNansi López-Valverde0Antonio López-Valverde1Bruno Macedo de Sousa2José Antonio Blanco Rueda3Department of Medicine and Medical Specialties, Faculty of Health Sciences, Universidad Alcalá de Henares, Madrid, SpainDepartment of Surgery, University of Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, SpainInstitute for Occlusion and Orofacial Pain Faculty of Medicine, University of Coimbra, Polo I‐Edifício Central Rua Larga, Coimbra, PortugalDepartment of Surgery, University of Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, SpainThis systematic review with meta-analysis evaluated the antioxidant effect of lycopene as an adjuvant treatment for periodontal disease. PubMed, EMBASE and Web of Science databases were consulted. According to the PICOs strategy, inclusion criteria were established for intervention studies Randomized Controlled Trials in Probing depth subjects (participants) treated with conventional treatment and lycopene (intervention) compared to patients treated with conventional treatment (control) in which periodontal response to treatment (outcome) was assessed. The risk of bias for randomized studies was assessed using the Cochrane Risk of Bias Tool. The methodological quality of the studies included in the meta-analysis was measured using the Jadad scale. Quantitative data were analyzed using six random-effects meta-analyses, taking into account periodontal parameters: Probing Pocket Depth, Clinical Attachment Loss, Bleeding on Probing, Plaque Index, Uric Acid and Gingival Index. Six further meta-analyses were performed, according to the follow-up of the studies (short-, medium- and long-term). Of the 339 studies identified, only 7 met the eligibility criteria. The meta-analysis of the studies according to the parameters evaluated only obtained statistical significance in the assessment of plaque index (p = 0.003). Regarding follow-up periods, PPD was significant (p = 0.03) in the short term. bleeding on probing estimates were significant in the short and medium term (p = 0.008 and p = 0.03, respectively), IP was significant in the short and medium term (p = 0.0003 and p = 0.01, respectively) and gingival index in the short and medium term (p = 0.002 and p = 0.02, respectively). Heterogeneity was high (I2 >50%) in all assessments, except for Clinical Attachment Loss (I2 = 16.7%). The results demonstrate that antioxidant treatment with lycopene could be useful as an adjunctive treatment for periodontal disease.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1309851/fulllycopeneantioxidantperiodontal diseasegingivitisperiodontitismeta-analysis |
| spellingShingle | Nansi López-Valverde Antonio López-Valverde Bruno Macedo de Sousa José Antonio Blanco Rueda Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease Frontiers in Bioengineering and Biotechnology lycopene antioxidant periodontal disease gingivitis periodontitis meta-analysis |
| title | Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease |
| title_full | Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease |
| title_fullStr | Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease |
| title_full_unstemmed | Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease |
| title_short | Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease |
| title_sort | systematic review and meta analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease |
| topic | lycopene antioxidant periodontal disease gingivitis periodontitis meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1309851/full |
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