Review of the mechanism of biomimetic intrafibrillar mineralization
Bone is a hierarchically structured and highly mineralized hard tissue composed of an organic phase (type I collagen and noncollagenous proteins) and an inorganic phase (nanohydroxyapatite). Intrafibrillar mineralized col⁃ lagen is the basic structural unit of bone tissue and is of high significan...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2018-06-01
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| Series: | 口腔疾病防治 |
| Subjects: | |
| Online Access: | http://www.kqjbfz.com/EN/10.12016/j.issn.2096-1456.2018.06.002 |
| _version_ | 1818837875463028736 |
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| author | NIU Lina CHEN Jihua JIAO Kai |
| author_facet | NIU Lina CHEN Jihua JIAO Kai |
| author_sort | NIU Lina |
| collection | DOAJ |
| description | Bone is a hierarchically structured and highly mineralized hard tissue composed of an organic phase
(type I collagen and noncollagenous proteins) and an inorganic phase (nanohydroxyapatite). Intrafibrillar mineralized col⁃
lagen is the basic structural unit of bone tissue and is of high significance due to its superior mechanical and biological
properties. Thus, to truly understand the unique properties of bone, it is necessary to review the most basic structural
level of bone. In this article, we review the recent advances in understanding the development of intrafibrillar mineral⁃
ization and the prevailing theories in the formation of such intrafibrillar minerals. Understanding the mechanisms of in⁃
trafibrillar mineralization may facilitate the development of engineered bone for clinical applications and provide deeper
insight into the nature of biomineralization. |
| first_indexed | 2024-12-19T03:29:27Z |
| format | Article |
| id | doaj.art-93871db6c2354505844f5c5910cb9201 |
| institution | Directory Open Access Journal |
| issn | 2096-1456 2096-1456 |
| language | zho |
| last_indexed | 2024-12-19T03:29:27Z |
| publishDate | 2018-06-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-93871db6c2354505844f5c5910cb92012022-12-21T20:37:33ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562096-14562018-06-0126634735310.12016/j.issn.2096⁃1456.2018.06.002Review of the mechanism of biomimetic intrafibrillar mineralizationNIU Lina0CHEN Jihua1JIAO Kai2State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical UniversityBone is a hierarchically structured and highly mineralized hard tissue composed of an organic phase (type I collagen and noncollagenous proteins) and an inorganic phase (nanohydroxyapatite). Intrafibrillar mineralized col⁃ lagen is the basic structural unit of bone tissue and is of high significance due to its superior mechanical and biological properties. Thus, to truly understand the unique properties of bone, it is necessary to review the most basic structural level of bone. In this article, we review the recent advances in understanding the development of intrafibrillar mineral⁃ ization and the prevailing theories in the formation of such intrafibrillar minerals. Understanding the mechanisms of in⁃ trafibrillar mineralization may facilitate the development of engineered bone for clinical applications and provide deeper insight into the nature of biomineralization.http://www.kqjbfz.com/EN/10.12016/j.issn.2096-1456.2018.06.002Biomimetic mineralizationNon⁃collagenous proteinIntrafibrillar mineralizationAmorphous calcium phosphatePre⁃nucleation cluster |
| spellingShingle | NIU Lina CHEN Jihua JIAO Kai Review of the mechanism of biomimetic intrafibrillar mineralization 口腔疾病防治 Biomimetic mineralization Non⁃collagenous protein Intrafibrillar mineralization Amorphous calcium phosphate Pre⁃nucleation cluster |
| title | Review of the mechanism of biomimetic intrafibrillar mineralization |
| title_full | Review of the mechanism of biomimetic intrafibrillar mineralization |
| title_fullStr | Review of the mechanism of biomimetic intrafibrillar mineralization |
| title_full_unstemmed | Review of the mechanism of biomimetic intrafibrillar mineralization |
| title_short | Review of the mechanism of biomimetic intrafibrillar mineralization |
| title_sort | review of the mechanism of biomimetic intrafibrillar mineralization |
| topic | Biomimetic mineralization Non⁃collagenous protein Intrafibrillar mineralization Amorphous calcium phosphate Pre⁃nucleation cluster |
| url | http://www.kqjbfz.com/EN/10.12016/j.issn.2096-1456.2018.06.002 |
| work_keys_str_mv | AT niulina reviewofthemechanismofbiomimeticintrafibrillarmineralization AT chenjihua reviewofthemechanismofbiomimeticintrafibrillarmineralization AT jiaokai reviewofthemechanismofbiomimeticintrafibrillarmineralization |