The effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chloride

There is no treatment for Alzheimer's disease. However, some treatments can have a slowing and controlling effect on the disease process. The aim of this study was to investigate the effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer'...

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Main Authors: Saeedeh Shadmehri, Afrooz Ramezanian
Format: Article
Language:English
Published: JEOCT publisher 2022-03-01
Series:Journal of Exercise & Organ Cross Talk
Subjects:
Online Access:https://www.jeoct.com/article_146977_500af0cc766db2a478b657454943068b.pdf
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author Saeedeh Shadmehri
Afrooz Ramezanian
author_facet Saeedeh Shadmehri
Afrooz Ramezanian
author_sort Saeedeh Shadmehri
collection DOAJ
description There is no treatment for Alzheimer's disease. However, some treatments can have a slowing and controlling effect on the disease process. The aim of this study was to investigate the effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chloride. In this experimental study, 32 male Sprague-Dawley rats with the weight of 180±20 g were selected and after Alzheimer's induction (by intraperitoneal injection of 80 mg/kg trimethyltin chloride) were randomly divided into 4 groups; control, aerobic training, saffron extract, saffron extract- aerobic training. Saffron extract was injected intraperitoneally at the dose of 25 mg/kg daily for eight weeks. The aerobic training program consisted of incremental running on the treadmill at a speed of 15 to 20 m/min and 15 to 30 min per session and 3 sessions per week for 8 weeks. Data were analyzed using two-way ANOVA at the P<0.05. The results showed that aerobic training (P=0.13), saffron extract (P=0.14) and the interaction of aerobic training and saffron extract (P=0.13) had no significant effect on apo E4in rats. Also, aerobic training (P=0.68), saffron consumption (P=0.67) and interaction of aerobic training and saffron extract (P=0.32) had no significant effect on persniline gene in rats. According to the results, it seems that aerobic training and saffron extract do not significantly alter the levels of apo E4 and the presenilin of Alzheimer's rats.
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spelling doaj.art-9387874c55b1421899983d19066414052023-12-03T15:27:28ZengJEOCT publisherJournal of Exercise & Organ Cross Talk2783-20742022-03-0121152110.22034/jeoct.2022.334360.1033146977The effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chlorideSaeedeh Shadmehri0Afrooz Ramezanian1Department of Physical Education and Sport Sciences, Yadegar-e-Imam Khomeini (RAH) Shahr-e Ray Branch, Islamic Azad University, Tehran, IranM.Sc. in Exercise Physiology, Marvdasht branch, Islamic Azad University, Marvdasht, Iran.There is no treatment for Alzheimer's disease. However, some treatments can have a slowing and controlling effect on the disease process. The aim of this study was to investigate the effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chloride. In this experimental study, 32 male Sprague-Dawley rats with the weight of 180±20 g were selected and after Alzheimer's induction (by intraperitoneal injection of 80 mg/kg trimethyltin chloride) were randomly divided into 4 groups; control, aerobic training, saffron extract, saffron extract- aerobic training. Saffron extract was injected intraperitoneally at the dose of 25 mg/kg daily for eight weeks. The aerobic training program consisted of incremental running on the treadmill at a speed of 15 to 20 m/min and 15 to 30 min per session and 3 sessions per week for 8 weeks. Data were analyzed using two-way ANOVA at the P<0.05. The results showed that aerobic training (P=0.13), saffron extract (P=0.14) and the interaction of aerobic training and saffron extract (P=0.13) had no significant effect on apo E4in rats. Also, aerobic training (P=0.68), saffron consumption (P=0.67) and interaction of aerobic training and saffron extract (P=0.32) had no significant effect on persniline gene in rats. According to the results, it seems that aerobic training and saffron extract do not significantly alter the levels of apo E4 and the presenilin of Alzheimer's rats.https://www.jeoct.com/article_146977_500af0cc766db2a478b657454943068b.pdfalzheimerexercisesaffron extractapo e4persniline
spellingShingle Saeedeh Shadmehri
Afrooz Ramezanian
The effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chloride
Journal of Exercise & Organ Cross Talk
alzheimer
exercise
saffron extract
apo e4
persniline
title The effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chloride
title_full The effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chloride
title_fullStr The effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chloride
title_full_unstemmed The effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chloride
title_short The effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chloride
title_sort effect of aerobic training with saffron extract on plasma levels of apo e4 and presenilin gene in alzheimer s rats by trimethyltin chloride
topic alzheimer
exercise
saffron extract
apo e4
persniline
url https://www.jeoct.com/article_146977_500af0cc766db2a478b657454943068b.pdf
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