Association between gestational weight gain and preterm birth and post-term birth: a longitudinal study from the National Vital Statistics System database
Abstract Background To evaluate the association between gestational weight gain (GWG) and preterm birth and post-term birth. Methods This longitudinal-based research studied singleton pregnant women from the National Vital Statistics System (NVSS) (2019). Total GWG (kg) was converted to gestational...
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BMC
2023-03-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-023-03951-0 |
| _version_ | 1797863549112942592 |
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| author | Yifang Zhu Jiani Zhang Qiaoyu Li Min Lin |
| author_facet | Yifang Zhu Jiani Zhang Qiaoyu Li Min Lin |
| author_sort | Yifang Zhu |
| collection | DOAJ |
| description | Abstract Background To evaluate the association between gestational weight gain (GWG) and preterm birth and post-term birth. Methods This longitudinal-based research studied singleton pregnant women from the National Vital Statistics System (NVSS) (2019). Total GWG (kg) was converted to gestational age-standardized z scores. The z-scores of GWG were divided into four categories according to the quartile of GWG, and the quantile 2 interval was used as the reference for the analysis. Univariate and multivariate logistic regression analyses were performed to investigate the association between GWG and preterm birth, post-term birth, and total adverse outcome (preterm birth + post-term birth). Subgroup analysis stratified by pre-pregnancy body mass index (BMI) was used to estimate associations between z-scores and outcomes. Results Of the 3,100,122 women, preterm birth occurred in 9.45% (292,857) population, with post-term birth accounting for 4.54% (140,851). The results demonstrated that low GWG z-score [odds ratio (OR): 1.04, 95% confidence interval (CI): 1.03 to 1.05, P < 0.001], and higher GWG z-scores (quantile 3: OR: 1.42, 95% CI: 1.41 to 1.44, P < 0.001; quantile 4: OR: 2.79, 95% CI: 2.76 to 2.82, P < 0.001) were positively associated with preterm birth. Low GWG z-score (OR: 1.18, 95% CI: 1.16 to 1.19, P < 0.001) was positively associated with an increased risk of post-term birth. However, higher GWG z-scores (quantile 3: OR: 0.84, 95% CI: 0.83 to 0.85, P < 0.001; quantile 4: 0.59, 95% CI: 0.58 to 0.60, P < 0.001) was associated with a decreased risk of post-term birth. In addition, low GWG z-score and higher GWG z-scores were related to total adverse outcome. A subgroup analysis demonstrated that pre-pregnancy BMI, low GWG z-score was associated with a decreased risk of preterm birth among BMI-obesity women (OR: 0.96, 95% CI: 0.94 to 0.98, P < 0.001). Conclusion Our result suggests that the management of GWG may be an important strategy to reduce the number of preterm birth and post-term birth. |
| first_indexed | 2024-04-09T22:37:17Z |
| format | Article |
| id | doaj.art-938903e561c040e5ab231932be5e5671 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-04-09T22:37:17Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
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| series | BMC Pediatrics |
| spelling | doaj.art-938903e561c040e5ab231932be5e56712023-03-22T12:24:06ZengBMCBMC Pediatrics1471-24312023-03-0123111110.1186/s12887-023-03951-0Association between gestational weight gain and preterm birth and post-term birth: a longitudinal study from the National Vital Statistics System databaseYifang Zhu0Jiani Zhang1Qiaoyu Li2Min Lin3Department of Pediatrics, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Pediatrics, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Pediatrics, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Pediatrics, The Second Affiliated Hospital of Fujian Medical UniversityAbstract Background To evaluate the association between gestational weight gain (GWG) and preterm birth and post-term birth. Methods This longitudinal-based research studied singleton pregnant women from the National Vital Statistics System (NVSS) (2019). Total GWG (kg) was converted to gestational age-standardized z scores. The z-scores of GWG were divided into four categories according to the quartile of GWG, and the quantile 2 interval was used as the reference for the analysis. Univariate and multivariate logistic regression analyses were performed to investigate the association between GWG and preterm birth, post-term birth, and total adverse outcome (preterm birth + post-term birth). Subgroup analysis stratified by pre-pregnancy body mass index (BMI) was used to estimate associations between z-scores and outcomes. Results Of the 3,100,122 women, preterm birth occurred in 9.45% (292,857) population, with post-term birth accounting for 4.54% (140,851). The results demonstrated that low GWG z-score [odds ratio (OR): 1.04, 95% confidence interval (CI): 1.03 to 1.05, P < 0.001], and higher GWG z-scores (quantile 3: OR: 1.42, 95% CI: 1.41 to 1.44, P < 0.001; quantile 4: OR: 2.79, 95% CI: 2.76 to 2.82, P < 0.001) were positively associated with preterm birth. Low GWG z-score (OR: 1.18, 95% CI: 1.16 to 1.19, P < 0.001) was positively associated with an increased risk of post-term birth. However, higher GWG z-scores (quantile 3: OR: 0.84, 95% CI: 0.83 to 0.85, P < 0.001; quantile 4: 0.59, 95% CI: 0.58 to 0.60, P < 0.001) was associated with a decreased risk of post-term birth. In addition, low GWG z-score and higher GWG z-scores were related to total adverse outcome. A subgroup analysis demonstrated that pre-pregnancy BMI, low GWG z-score was associated with a decreased risk of preterm birth among BMI-obesity women (OR: 0.96, 95% CI: 0.94 to 0.98, P < 0.001). Conclusion Our result suggests that the management of GWG may be an important strategy to reduce the number of preterm birth and post-term birth.https://doi.org/10.1186/s12887-023-03951-0Preterm birthPost-term birthGestational weight gainBody mass index |
| spellingShingle | Yifang Zhu Jiani Zhang Qiaoyu Li Min Lin Association between gestational weight gain and preterm birth and post-term birth: a longitudinal study from the National Vital Statistics System database BMC Pediatrics Preterm birth Post-term birth Gestational weight gain Body mass index |
| title | Association between gestational weight gain and preterm birth and post-term birth: a longitudinal study from the National Vital Statistics System database |
| title_full | Association between gestational weight gain and preterm birth and post-term birth: a longitudinal study from the National Vital Statistics System database |
| title_fullStr | Association between gestational weight gain and preterm birth and post-term birth: a longitudinal study from the National Vital Statistics System database |
| title_full_unstemmed | Association between gestational weight gain and preterm birth and post-term birth: a longitudinal study from the National Vital Statistics System database |
| title_short | Association between gestational weight gain and preterm birth and post-term birth: a longitudinal study from the National Vital Statistics System database |
| title_sort | association between gestational weight gain and preterm birth and post term birth a longitudinal study from the national vital statistics system database |
| topic | Preterm birth Post-term birth Gestational weight gain Body mass index |
| url | https://doi.org/10.1186/s12887-023-03951-0 |
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