Circulating choline pathway nutrients and risk of moyamoya disease
BackgroundCirculating choline pathway nutrients play a critical role in first stroke and recurrent stroke. However, there is limited information available on the effects of choline pathway nutrients on the risk of moyamoya disease (MMD) and its subtypes. We investigated the association between circu...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.953426/full |
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| author | Peicong Ge Peicong Ge Peicong Ge Peicong Ge Peicong Ge Yaobo Zhao Yaobo Zhao Yuanren Zhai Yuanren Zhai Yuanren Zhai Yuanren Zhai Yuanren Zhai Qian Zhang Qian Zhang Qian Zhang Qian Zhang Qian Zhang Xun Ye Xun Ye Xun Ye Xun Ye Xun Ye Jia Wang Jia Wang Jia Wang Jia Wang Jia Wang Rong Wang Rong Wang Rong Wang Rong Wang Rong Wang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Dong Zhang Dong Zhang Dong Zhang Dong Zhang Dong Zhang Dong Zhang Jizong Zhao Jizong Zhao Jizong Zhao Jizong Zhao Jizong Zhao Jizong Zhao |
| author_facet | Peicong Ge Peicong Ge Peicong Ge Peicong Ge Peicong Ge Yaobo Zhao Yaobo Zhao Yuanren Zhai Yuanren Zhai Yuanren Zhai Yuanren Zhai Yuanren Zhai Qian Zhang Qian Zhang Qian Zhang Qian Zhang Qian Zhang Xun Ye Xun Ye Xun Ye Xun Ye Xun Ye Jia Wang Jia Wang Jia Wang Jia Wang Jia Wang Rong Wang Rong Wang Rong Wang Rong Wang Rong Wang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Dong Zhang Dong Zhang Dong Zhang Dong Zhang Dong Zhang Dong Zhang Jizong Zhao Jizong Zhao Jizong Zhao Jizong Zhao Jizong Zhao Jizong Zhao |
| author_sort | Peicong Ge |
| collection | DOAJ |
| description | BackgroundCirculating choline pathway nutrients play a critical role in first stroke and recurrent stroke. However, there is limited information available on the effects of choline pathway nutrients on the risk of moyamoya disease (MMD) and its subtypes. We investigated the association between circulating choline and betaine and the incident risk of MMD and its subtypes.MethodsThe case-control study enrolled 385 patients with MMD [i.e., 110 transient ischemic attack (TIA)-type MMD, 157 infarction-type MMD, and 118 hemorrhagic-type MMD] and 89 matched healthy controls.ResultsSerum choline and betaine were inversely related to the risk of MMD and its subtypes. The risk of MMD was decreased with each increment in choline level [per 1 μmol increase: odds ratio (OR), 0.756; 95% CI, 0.678–0.843] and betaine level (per 1 μmol increase: OR, 0.952; 95% CI, 0.932–0.972), respectively. When choline and betaine were assessed as quartiles, compared with the lowest quartile of serum choline and betaine levels, those in the highest quartile had a significantly decreased risk of MMD (choline, Q4 vs. Q1: OR, 0.023; 95% CI, 0.005–0.118; betaine, Q4 vs. Q1: OR, 0.058; 95% CI, 0.018–0.184).ConclusionsSerum choline and betaine were associated with the decreased risk of MMD and its subtypes. |
| first_indexed | 2024-12-10T17:41:34Z |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-10T17:41:34Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-938cb2c930f74268b5ee439b340e8adc2022-12-22T01:39:22ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-08-01910.3389/fnut.2022.953426953426Circulating choline pathway nutrients and risk of moyamoya diseasePeicong Ge0Peicong Ge1Peicong Ge2Peicong Ge3Peicong Ge4Yaobo Zhao5Yaobo Zhao6Yuanren Zhai7Yuanren Zhai8Yuanren Zhai9Yuanren Zhai10Yuanren Zhai11Qian Zhang12Qian Zhang13Qian Zhang14Qian Zhang15Qian Zhang16Xun Ye17Xun Ye18Xun Ye19Xun Ye20Xun Ye21Jia Wang22Jia Wang23Jia Wang24Jia Wang25Jia Wang26Rong Wang27Rong Wang28Rong Wang29Rong Wang30Rong Wang31Yan Zhang32Yan Zhang33Yan Zhang34Yan Zhang35Yan Zhang36Dong Zhang37Dong Zhang38Dong Zhang39Dong Zhang40Dong Zhang41Dong Zhang42Jizong Zhao43Jizong Zhao44Jizong Zhao45Jizong Zhao46Jizong Zhao47Jizong Zhao48Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaBeijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaBeijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaBeijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaBeijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaBeijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaBeijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaBeijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaBeijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, ChinaDepartment of Neurosurgery, Beijing Hospital, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaBeijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, ChinaSavaid Medical School, University of Chinese Academy of Sciences, Beijing, ChinaBackgroundCirculating choline pathway nutrients play a critical role in first stroke and recurrent stroke. However, there is limited information available on the effects of choline pathway nutrients on the risk of moyamoya disease (MMD) and its subtypes. We investigated the association between circulating choline and betaine and the incident risk of MMD and its subtypes.MethodsThe case-control study enrolled 385 patients with MMD [i.e., 110 transient ischemic attack (TIA)-type MMD, 157 infarction-type MMD, and 118 hemorrhagic-type MMD] and 89 matched healthy controls.ResultsSerum choline and betaine were inversely related to the risk of MMD and its subtypes. The risk of MMD was decreased with each increment in choline level [per 1 μmol increase: odds ratio (OR), 0.756; 95% CI, 0.678–0.843] and betaine level (per 1 μmol increase: OR, 0.952; 95% CI, 0.932–0.972), respectively. When choline and betaine were assessed as quartiles, compared with the lowest quartile of serum choline and betaine levels, those in the highest quartile had a significantly decreased risk of MMD (choline, Q4 vs. Q1: OR, 0.023; 95% CI, 0.005–0.118; betaine, Q4 vs. Q1: OR, 0.058; 95% CI, 0.018–0.184).ConclusionsSerum choline and betaine were associated with the decreased risk of MMD and its subtypes.https://www.frontiersin.org/articles/10.3389/fnut.2022.953426/fullmoyamoyacholinebetainerisk factorssubtypes |
| spellingShingle | Peicong Ge Peicong Ge Peicong Ge Peicong Ge Peicong Ge Yaobo Zhao Yaobo Zhao Yuanren Zhai Yuanren Zhai Yuanren Zhai Yuanren Zhai Yuanren Zhai Qian Zhang Qian Zhang Qian Zhang Qian Zhang Qian Zhang Xun Ye Xun Ye Xun Ye Xun Ye Xun Ye Jia Wang Jia Wang Jia Wang Jia Wang Jia Wang Rong Wang Rong Wang Rong Wang Rong Wang Rong Wang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Dong Zhang Dong Zhang Dong Zhang Dong Zhang Dong Zhang Dong Zhang Jizong Zhao Jizong Zhao Jizong Zhao Jizong Zhao Jizong Zhao Jizong Zhao Circulating choline pathway nutrients and risk of moyamoya disease Frontiers in Nutrition moyamoya choline betaine risk factors subtypes |
| title | Circulating choline pathway nutrients and risk of moyamoya disease |
| title_full | Circulating choline pathway nutrients and risk of moyamoya disease |
| title_fullStr | Circulating choline pathway nutrients and risk of moyamoya disease |
| title_full_unstemmed | Circulating choline pathway nutrients and risk of moyamoya disease |
| title_short | Circulating choline pathway nutrients and risk of moyamoya disease |
| title_sort | circulating choline pathway nutrients and risk of moyamoya disease |
| topic | moyamoya choline betaine risk factors subtypes |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.953426/full |
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