K-RAS Gene Mutations in Patients with Non-small Cell Lung Cancer
Background and objective Recent studies indicated that Non-small cell lung cancer (NSCLC) patients with mutant K-RAS failed to benefit from adjuvant chemotherapy, and the cancer did not respond to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). These findings indicated tha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2010-06-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.06.007&path[]=1542 |
| _version_ | 1818026585798737920 |
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| author | Yang ZHANG Zhenkui PAN Xing ZHANG Fei XU Li ZHANG |
| author_facet | Yang ZHANG Zhenkui PAN Xing ZHANG Fei XU Li ZHANG |
| author_sort | Yang ZHANG |
| collection | DOAJ |
| description | Background and objective Recent studies indicated that Non-small cell lung cancer (NSCLC) patients with mutant K-RAS failed to benefit from adjuvant chemotherapy, and the cancer did not respond to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). These findings indicated that K-RAS gene status can be a biomarker to predict the sensitivity of EGFR TKIs. The aim of this study is to analyze K-RAS gene mutations with NSCLC patients in Cancer Center of Sun Yet-sen University. Methods 52 fresh frozen tumor tissues were collected and K-RAS genes were amplified by PCR. Then PCR amplification fragments were sequenced and analyzed. Results Somatic mutations in the codon 12 of K-RAS gene in tumors were identified from 2 of 52 (3.8%) patients. There were no relationships among K-RAS gene mutations and gender, pathology, smoking, differentiation and stage. Conclusion The frequency of K-RAS gene mutations with NSCLC in our center is very low and is similar to that in Asia patients, and is lower than that in Caucasian population. |
| first_indexed | 2024-12-10T04:34:21Z |
| format | Article |
| id | doaj.art-938d3788aabd4763b065518782103627 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-10T04:34:21Z |
| publishDate | 2010-06-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-938d3788aabd4763b0655187821036272022-12-22T02:02:04ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872010-06-01136602606K-RAS Gene Mutations in Patients with Non-small Cell Lung CancerYang ZHANGZhenkui PANXing ZHANGFei XULi ZHANGBackground and objective Recent studies indicated that Non-small cell lung cancer (NSCLC) patients with mutant K-RAS failed to benefit from adjuvant chemotherapy, and the cancer did not respond to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). These findings indicated that K-RAS gene status can be a biomarker to predict the sensitivity of EGFR TKIs. The aim of this study is to analyze K-RAS gene mutations with NSCLC patients in Cancer Center of Sun Yet-sen University. Methods 52 fresh frozen tumor tissues were collected and K-RAS genes were amplified by PCR. Then PCR amplification fragments were sequenced and analyzed. Results Somatic mutations in the codon 12 of K-RAS gene in tumors were identified from 2 of 52 (3.8%) patients. There were no relationships among K-RAS gene mutations and gender, pathology, smoking, differentiation and stage. Conclusion The frequency of K-RAS gene mutations with NSCLC in our center is very low and is similar to that in Asia patients, and is lower than that in Caucasian population.http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.06.007&path[]=1542Lung neoplasmsRAS geneMutation |
| spellingShingle | Yang ZHANG Zhenkui PAN Xing ZHANG Fei XU Li ZHANG K-RAS Gene Mutations in Patients with Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms RAS gene Mutation |
| title | K-RAS Gene Mutations in Patients with Non-small Cell Lung Cancer |
| title_full | K-RAS Gene Mutations in Patients with Non-small Cell Lung Cancer |
| title_fullStr | K-RAS Gene Mutations in Patients with Non-small Cell Lung Cancer |
| title_full_unstemmed | K-RAS Gene Mutations in Patients with Non-small Cell Lung Cancer |
| title_short | K-RAS Gene Mutations in Patients with Non-small Cell Lung Cancer |
| title_sort | k ras gene mutations in patients with non small cell lung cancer |
| topic | Lung neoplasms RAS gene Mutation |
| url | http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.06.007&path[]=1542 |
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