Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate.
AIM:To evaluate the influence of dietary lipid quality on the body mass, carbohydrate metabolism and morphology of the rat ventral prostate. MATERIALS AND METHODS:Wistar rats were divided into four groups: SC (standard chow), HF-S (high-fat diet rich in saturated fatty acids), HF-P (high-fat diet ri...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4100933?pdf=render |
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| author | Angélica Furriel Pamella Campos-Silva Paola Cariello Guedes Picarote Silva Waldemar Silva Costa Francisco José Barcellos Sampaio Bianca Martins Gregório |
| author_facet | Angélica Furriel Pamella Campos-Silva Paola Cariello Guedes Picarote Silva Waldemar Silva Costa Francisco José Barcellos Sampaio Bianca Martins Gregório |
| author_sort | Angélica Furriel |
| collection | DOAJ |
| description | AIM:To evaluate the influence of dietary lipid quality on the body mass, carbohydrate metabolism and morphology of the rat ventral prostate. MATERIALS AND METHODS:Wistar rats were divided into four groups: SC (standard chow), HF-S (high-fat diet rich in saturated fatty acids), HF-P (high-fat diet rich in polyunsaturated fatty acids) and HF-SP (high-fat diet rich in saturated and polyunsaturated fatty acids). We analyzed body mass, fat mass deposits, plasma blood, insulin resistance and the ventral prostate structure. RESULTS:Groups that received high-fat diets were heavier and presented larger fat deposits than SC group. The HF-S and HF-SP groups had higher glucose, insulin and total cholesterol serum levels and insulin resistance compared with the SC. The acinar area, epithelium height and area density of the lumen were higher in the HF-SP than in the other groups. The epithelium area density and epithelial cell proliferation were greater in the HF-P and HF-SP than in the SC group. All of the groups that received high-fat diets had greater area density of the stroma, area density of smooth muscle cells and stromal cell proliferation compared with the SC group. CONCLUSION:Diets rich in saturated and/or polyunsaturated fatty acids induced overweight. Independently of insulin resistance, polyunsaturated fatty acids increased prostate stromal and epithelial cell proliferation. Saturated fatty acids influenced only stromal cellular proliferation. These structural and morphometric alterations may be considered risk factors for the development of adverse remodeling process in the rat ventral prostate. |
| first_indexed | 2024-04-14T06:26:19Z |
| format | Article |
| id | doaj.art-93902a1f5bf8425b9e5f7efcb6e6c6e3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T06:26:19Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-93902a1f5bf8425b9e5f7efcb6e6c6e32022-12-22T02:07:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10287610.1371/journal.pone.0102876Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate.Angélica FurrielPamella Campos-SilvaPaola Cariello Guedes Picarote SilvaWaldemar Silva CostaFrancisco José Barcellos SampaioBianca Martins GregórioAIM:To evaluate the influence of dietary lipid quality on the body mass, carbohydrate metabolism and morphology of the rat ventral prostate. MATERIALS AND METHODS:Wistar rats were divided into four groups: SC (standard chow), HF-S (high-fat diet rich in saturated fatty acids), HF-P (high-fat diet rich in polyunsaturated fatty acids) and HF-SP (high-fat diet rich in saturated and polyunsaturated fatty acids). We analyzed body mass, fat mass deposits, plasma blood, insulin resistance and the ventral prostate structure. RESULTS:Groups that received high-fat diets were heavier and presented larger fat deposits than SC group. The HF-S and HF-SP groups had higher glucose, insulin and total cholesterol serum levels and insulin resistance compared with the SC. The acinar area, epithelium height and area density of the lumen were higher in the HF-SP than in the other groups. The epithelium area density and epithelial cell proliferation were greater in the HF-P and HF-SP than in the SC group. All of the groups that received high-fat diets had greater area density of the stroma, area density of smooth muscle cells and stromal cell proliferation compared with the SC group. CONCLUSION:Diets rich in saturated and/or polyunsaturated fatty acids induced overweight. Independently of insulin resistance, polyunsaturated fatty acids increased prostate stromal and epithelial cell proliferation. Saturated fatty acids influenced only stromal cellular proliferation. These structural and morphometric alterations may be considered risk factors for the development of adverse remodeling process in the rat ventral prostate.http://europepmc.org/articles/PMC4100933?pdf=render |
| spellingShingle | Angélica Furriel Pamella Campos-Silva Paola Cariello Guedes Picarote Silva Waldemar Silva Costa Francisco José Barcellos Sampaio Bianca Martins Gregório Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate. PLoS ONE |
| title | Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate. |
| title_full | Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate. |
| title_fullStr | Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate. |
| title_full_unstemmed | Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate. |
| title_short | Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate. |
| title_sort | diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate |
| url | http://europepmc.org/articles/PMC4100933?pdf=render |
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