Gorham–Stout disease with life-threatening pleural effusion treated with a pleuro-peritoneal shunt: a case report
Gorham–Stout disease (GSD) is a rare bone disease characterized by massive osteolysis and lymphatic proliferation. The origin of the condition is unknown, and no established treatment protocol exists. Massive pleural effusion is a frequent complication of GSD in the thoracic region. We present the c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-06-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
| Online Access: | https://edm.bioscientifica.com/view/journals/edm/2022/1/EDM21-0101.xml |
| _version_ | 1828832138576789504 |
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| author | Leevi A Toivonen Marko H Neva Thanos Sioris Pia Isomäki Saara Metso |
| author_facet | Leevi A Toivonen Marko H Neva Thanos Sioris Pia Isomäki Saara Metso |
| author_sort | Leevi A Toivonen |
| collection | DOAJ |
| description | Gorham–Stout disease (GSD) is a rare bone disease characterized by massive osteolysis and lymphatic proliferation. The origin of the condition is unknown, and no established treatment protocol exists. Massive pleural effusion is a frequent complication of GSD in the thoracic region. We present the case of a 23-year-old male with thoracic GSD, subsequent paraparesis, and life-threatening pleural effusion. The patient was managed by a multidisciplinary team with a good recovery. The pleural effusion was successfully treated with a pleuro-peritoneal shunt. This is the first report of the use of this mini-invasive technique in the management of pleural effusion related to GSD. Further, we present the potential role of interleukin-6 and bone resorption markers in the measurement of the disease activity. |
| first_indexed | 2024-12-12T16:47:45Z |
| format | Article |
| id | doaj.art-93918d4f9f044cf1804c7cf53d3436a2 |
| institution | Directory Open Access Journal |
| issn | 2052-0573 |
| language | English |
| last_indexed | 2024-12-12T16:47:45Z |
| publishDate | 2022-06-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj.art-93918d4f9f044cf1804c7cf53d3436a22022-12-22T00:18:26ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732022-06-01111510.1530/EDM-21-0101Gorham–Stout disease with life-threatening pleural effusion treated with a pleuro-peritoneal shunt: a case reportLeevi A Toivonen0Marko H Neva1Thanos Sioris2Pia Isomäki3Saara Metso4Department of Orthopaedic and Trauma SurgeryDepartment of Orthopaedic and Trauma SurgeryDepartment of Cardiothoracic SurgeryCentre for Rheumatic Diseases, Department of Internal MedicineUnit of Endocrinology, Department of Internal Medicine, Faculty of Medicine and Health Technology, Tampere University, Tampere University Hospital, Tampere, FinlandGorham–Stout disease (GSD) is a rare bone disease characterized by massive osteolysis and lymphatic proliferation. The origin of the condition is unknown, and no established treatment protocol exists. Massive pleural effusion is a frequent complication of GSD in the thoracic region. We present the case of a 23-year-old male with thoracic GSD, subsequent paraparesis, and life-threatening pleural effusion. The patient was managed by a multidisciplinary team with a good recovery. The pleural effusion was successfully treated with a pleuro-peritoneal shunt. This is the first report of the use of this mini-invasive technique in the management of pleural effusion related to GSD. Further, we present the potential role of interleukin-6 and bone resorption markers in the measurement of the disease activity.https://edm.bioscientifica.com/view/journals/edm/2022/1/EDM21-0101.xml |
| spellingShingle | Leevi A Toivonen Marko H Neva Thanos Sioris Pia Isomäki Saara Metso Gorham–Stout disease with life-threatening pleural effusion treated with a pleuro-peritoneal shunt: a case report Endocrinology, Diabetes & Metabolism Case Reports |
| title | Gorham–Stout disease with life-threatening pleural effusion treated with a pleuro-peritoneal shunt: a case report |
| title_full | Gorham–Stout disease with life-threatening pleural effusion treated with a pleuro-peritoneal shunt: a case report |
| title_fullStr | Gorham–Stout disease with life-threatening pleural effusion treated with a pleuro-peritoneal shunt: a case report |
| title_full_unstemmed | Gorham–Stout disease with life-threatening pleural effusion treated with a pleuro-peritoneal shunt: a case report |
| title_short | Gorham–Stout disease with life-threatening pleural effusion treated with a pleuro-peritoneal shunt: a case report |
| title_sort | gorham stout disease with life threatening pleural effusion treated with a pleuro peritoneal shunt a case report |
| url | https://edm.bioscientifica.com/view/journals/edm/2022/1/EDM21-0101.xml |
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