Evaluation of optimal dose of intra-articular injection of Triamcinolone in treatment of tempromandibular joint arthritis in Rat
Introduction: 20-30% of adult population has experiences of temporomandibular joint (TMJ) disorders. Primary step for reduction of pain and joint dysfunction is nonsurgical treatments like Intra-articular injection of glucocorticosteroid. The aim of this investigation was to determine optimal dose o...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2009-01-01
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| Series: | مجله دانشکده دندانپزشکی اصفهان |
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| Online Access: | http://jids.mui.ac.ir/index.php/jids/article/view/140 |
| _version_ | 1797766802448580608 |
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| author | A Peymani |
| author_facet | A Peymani |
| author_sort | A Peymani |
| collection | DOAJ |
| description | Introduction: 20-30% of adult population has experiences of temporomandibular joint (TMJ) disorders. Primary step for reduction of pain and joint dysfunction is nonsurgical treatments like Intra-articular injection of glucocorticosteroid. The aim of this investigation was to determine optimal dose of triamcinolone injection in treatment of arthritis in order to control its side effects. Methods and Materials: In this experimental animal study, after the sedation of 25 rats, experimental chronic inflammation induced by injection of Complete Freund's Adjuvant (CFA) in left TMJ of all 5 groups. After 7 days, injection of Triamcinolone acetonide performed differently in five groups: Group A. 0.1 mg/kg; Group B. 0.2 mg/kg; Group C. 0.5 mg/kg; Group D. 1 mg/kg; and group E. only equivalent volume of normal saline. After 10 days, rats were sacrificed and according to modified Gynther system, three factors of inflammatory cells infiltration, vascularity and number of synovial cell layers were evaluated and got scored. Results: All the groups with injection of Triamcinolone acetonide showed lower scores but only differences in vascularity and number of synovial cells in group B were statistically significant and in addition group B showed more predictable results than other groups in every three factors. Conclusion: We suggest that the best dose of intra-articular injection of Triamcinolone acetonide in rat TMJ is 0.2 mg/kg which caused the most reasonable therapeutic results. So evaluating the optimal dose for human joint leads to achieve the best results with the least side effects is recommended.Key words: TMJ arthritis, intra-articular injection, Triamcinolone acetonide, rat |
| first_indexed | 2024-03-12T20:30:27Z |
| format | Article |
| id | doaj.art-9392aaccb5114ed680cf2164c2dee219 |
| institution | Directory Open Access Journal |
| issn | 1735-255X 2008-6989 |
| language | fas |
| last_indexed | 2024-03-12T20:30:27Z |
| publishDate | 2009-01-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده دندانپزشکی اصفهان |
| spelling | doaj.art-9392aaccb5114ed680cf2164c2dee2192023-08-02T00:07:53ZfasIsfahan University of Medical Sciencesمجله دانشکده دندانپزشکی اصفهان1735-255X2008-69892009-01-0144192198Evaluation of optimal dose of intra-articular injection of Triamcinolone in treatment of tempromandibular joint arthritis in RatA PeymaniIntroduction: 20-30% of adult population has experiences of temporomandibular joint (TMJ) disorders. Primary step for reduction of pain and joint dysfunction is nonsurgical treatments like Intra-articular injection of glucocorticosteroid. The aim of this investigation was to determine optimal dose of triamcinolone injection in treatment of arthritis in order to control its side effects. Methods and Materials: In this experimental animal study, after the sedation of 25 rats, experimental chronic inflammation induced by injection of Complete Freund's Adjuvant (CFA) in left TMJ of all 5 groups. After 7 days, injection of Triamcinolone acetonide performed differently in five groups: Group A. 0.1 mg/kg; Group B. 0.2 mg/kg; Group C. 0.5 mg/kg; Group D. 1 mg/kg; and group E. only equivalent volume of normal saline. After 10 days, rats were sacrificed and according to modified Gynther system, three factors of inflammatory cells infiltration, vascularity and number of synovial cell layers were evaluated and got scored. Results: All the groups with injection of Triamcinolone acetonide showed lower scores but only differences in vascularity and number of synovial cells in group B were statistically significant and in addition group B showed more predictable results than other groups in every three factors. Conclusion: We suggest that the best dose of intra-articular injection of Triamcinolone acetonide in rat TMJ is 0.2 mg/kg which caused the most reasonable therapeutic results. So evaluating the optimal dose for human joint leads to achieve the best results with the least side effects is recommended.Key words: TMJ arthritis, intra-articular injection, Triamcinolone acetonide, rathttp://jids.mui.ac.ir/index.php/jids/article/view/140Key words: TMJ arthritisintra-articular injectionTriamcinolone acetoniderat |
| spellingShingle | A Peymani Evaluation of optimal dose of intra-articular injection of Triamcinolone in treatment of tempromandibular joint arthritis in Rat مجله دانشکده دندانپزشکی اصفهان Key words: TMJ arthritis intra-articular injection Triamcinolone acetonide rat |
| title | Evaluation of optimal dose of intra-articular injection of Triamcinolone in treatment of tempromandibular joint arthritis in Rat |
| title_full | Evaluation of optimal dose of intra-articular injection of Triamcinolone in treatment of tempromandibular joint arthritis in Rat |
| title_fullStr | Evaluation of optimal dose of intra-articular injection of Triamcinolone in treatment of tempromandibular joint arthritis in Rat |
| title_full_unstemmed | Evaluation of optimal dose of intra-articular injection of Triamcinolone in treatment of tempromandibular joint arthritis in Rat |
| title_short | Evaluation of optimal dose of intra-articular injection of Triamcinolone in treatment of tempromandibular joint arthritis in Rat |
| title_sort | evaluation of optimal dose of intra articular injection of triamcinolone in treatment of tempromandibular joint arthritis in rat |
| topic | Key words: TMJ arthritis intra-articular injection Triamcinolone acetonide rat |
| url | http://jids.mui.ac.ir/index.php/jids/article/view/140 |
| work_keys_str_mv | AT apeymani evaluationofoptimaldoseofintraarticularinjectionoftriamcinoloneintreatmentoftempromandibularjointarthritisinrat |