Green Synthesis of Zinc Oxide Nanoparticles Using <i>Viscum album</i> Extracts: Unveiling Bioactive Compounds, Antibacterial Potential, and Antioxidant Activities
The current study explored the antioxidant and antibacterial capabilities of zinc oxide nanoparticles (ZnONPs) synthetized using methanolic leaf extracts of the medicinal herb <i>Viscum album</i>. Through TEM investigation and UV–Vis analysis, which peaked at 406 nm, the synthesis of ZnO...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/11/2130 |
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| author | Waheeda Mushtaq Muhammad Ishtiaq Mehwish Maqbool Muhammad Waqas Mazhar Ryan Casini Ahmed M. Abd-ElGawad Hosam O. Elansary |
| author_facet | Waheeda Mushtaq Muhammad Ishtiaq Mehwish Maqbool Muhammad Waqas Mazhar Ryan Casini Ahmed M. Abd-ElGawad Hosam O. Elansary |
| author_sort | Waheeda Mushtaq |
| collection | DOAJ |
| description | The current study explored the antioxidant and antibacterial capabilities of zinc oxide nanoparticles (ZnONPs) synthetized using methanolic leaf extracts of the medicinal herb <i>Viscum album</i>. Through TEM investigation and UV–Vis analysis, which peaked at 406 nm, the synthesis of ZnONPs was verified. TEM analyses showed that the synthesized ZnONPs had a size distribution with an average of 13.5 nm and a quasi-spherical shape. Forty-four phytoconstituents were found in the methanolic leaf extracts of <i>V. album</i>. Additionally, a comparison of the antibacterial effectiveness and antioxidant capacity of aqueous and methanolic extracts of wild-grown <i>V. album</i> phytomedicine and green-manufactured ZnONPs was conducted. The green-generated ZnONPs were examined against <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Pseudomonas aeruginosa</i> and shown to have superior antibacterial activity by 22%, 66%, and 44%, respectively, as compared to wild herbal medicinal extracts. Since the ZnONPs’ aqueous extracts had higher concentrations of DNA gyrase-B inhibitory components, they were shown to be more effective in limiting bacterial growth. In contrast to the percentages of 49% and 57% for a wild plant extract, the aqueous- and methanolic-extract-mediated green ZnONPs, with a 100 g/mL concentration, showed 94% and 98% scavenging capacity for DPPH free radicals, respectively. However, methanolic extracts were more effective than aqueous extracts in terms of the antioxidant analyses. This study establishes that greenly produced ZnONPs have the potential to be used in nanomedicine to treat bacteria that are resistant to a variety of drugs, as well as those with reactive oxygen species toxicity. |
| first_indexed | 2024-03-11T02:59:50Z |
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| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-11T02:59:50Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-9392c4c5721543a09865058195f3db0d2023-11-18T08:23:46ZengMDPI AGPlants2223-77472023-05-011211213010.3390/plants12112130Green Synthesis of Zinc Oxide Nanoparticles Using <i>Viscum album</i> Extracts: Unveiling Bioactive Compounds, Antibacterial Potential, and Antioxidant ActivitiesWaheeda Mushtaq0Muhammad Ishtiaq1Mehwish Maqbool2Muhammad Waqas Mazhar3Ryan Casini4Ahmed M. Abd-ElGawad5Hosam O. Elansary6Department of Botany, Mirpur University of Science & Technology (MUST), Mirpur 10250, PakistanDepartment of Botany, Mirpur University of Science & Technology (MUST), Mirpur 10250, PakistanDepartment of Botany, Mirpur University of Science & Technology (MUST), Mirpur 10250, PakistanDepartment of Botany, Mirpur University of Science & Technology (MUST), Mirpur 10250, PakistanSchool of Public Health, University of California, Berkeley, 2121 Berkeley Way, Berkeley, CA 94704, USADepartment of Plant Production, College of Food & Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi ArabiaDepartment of Plant Production, College of Food & Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi ArabiaThe current study explored the antioxidant and antibacterial capabilities of zinc oxide nanoparticles (ZnONPs) synthetized using methanolic leaf extracts of the medicinal herb <i>Viscum album</i>. Through TEM investigation and UV–Vis analysis, which peaked at 406 nm, the synthesis of ZnONPs was verified. TEM analyses showed that the synthesized ZnONPs had a size distribution with an average of 13.5 nm and a quasi-spherical shape. Forty-four phytoconstituents were found in the methanolic leaf extracts of <i>V. album</i>. Additionally, a comparison of the antibacterial effectiveness and antioxidant capacity of aqueous and methanolic extracts of wild-grown <i>V. album</i> phytomedicine and green-manufactured ZnONPs was conducted. The green-generated ZnONPs were examined against <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Pseudomonas aeruginosa</i> and shown to have superior antibacterial activity by 22%, 66%, and 44%, respectively, as compared to wild herbal medicinal extracts. Since the ZnONPs’ aqueous extracts had higher concentrations of DNA gyrase-B inhibitory components, they were shown to be more effective in limiting bacterial growth. In contrast to the percentages of 49% and 57% for a wild plant extract, the aqueous- and methanolic-extract-mediated green ZnONPs, with a 100 g/mL concentration, showed 94% and 98% scavenging capacity for DPPH free radicals, respectively. However, methanolic extracts were more effective than aqueous extracts in terms of the antioxidant analyses. This study establishes that greenly produced ZnONPs have the potential to be used in nanomedicine to treat bacteria that are resistant to a variety of drugs, as well as those with reactive oxygen species toxicity.https://www.mdpi.com/2223-7747/12/11/2130green synthesiszinc oxide nanoparticles<i>Viscum album</i>antimicrobial activitiesphytomedicines |
| spellingShingle | Waheeda Mushtaq Muhammad Ishtiaq Mehwish Maqbool Muhammad Waqas Mazhar Ryan Casini Ahmed M. Abd-ElGawad Hosam O. Elansary Green Synthesis of Zinc Oxide Nanoparticles Using <i>Viscum album</i> Extracts: Unveiling Bioactive Compounds, Antibacterial Potential, and Antioxidant Activities Plants green synthesis zinc oxide nanoparticles <i>Viscum album</i> antimicrobial activities phytomedicines |
| title | Green Synthesis of Zinc Oxide Nanoparticles Using <i>Viscum album</i> Extracts: Unveiling Bioactive Compounds, Antibacterial Potential, and Antioxidant Activities |
| title_full | Green Synthesis of Zinc Oxide Nanoparticles Using <i>Viscum album</i> Extracts: Unveiling Bioactive Compounds, Antibacterial Potential, and Antioxidant Activities |
| title_fullStr | Green Synthesis of Zinc Oxide Nanoparticles Using <i>Viscum album</i> Extracts: Unveiling Bioactive Compounds, Antibacterial Potential, and Antioxidant Activities |
| title_full_unstemmed | Green Synthesis of Zinc Oxide Nanoparticles Using <i>Viscum album</i> Extracts: Unveiling Bioactive Compounds, Antibacterial Potential, and Antioxidant Activities |
| title_short | Green Synthesis of Zinc Oxide Nanoparticles Using <i>Viscum album</i> Extracts: Unveiling Bioactive Compounds, Antibacterial Potential, and Antioxidant Activities |
| title_sort | green synthesis of zinc oxide nanoparticles using i viscum album i extracts unveiling bioactive compounds antibacterial potential and antioxidant activities |
| topic | green synthesis zinc oxide nanoparticles <i>Viscum album</i> antimicrobial activities phytomedicines |
| url | https://www.mdpi.com/2223-7747/12/11/2130 |
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