Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study
Abstract Background Regional citrate anticoagulation (RCA) is the gold standard of anticoagulation for continuous renal replacement therapy but is rarely used for intermittent hemodialysis (IHD) in ICU. Few studies assessed the safety and efficacy of RCA during IHD in ICU; however, no data are avail...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2021-01-01
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| Series: | Annals of Intensive Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13613-021-00803-x |
| _version_ | 1818676161235910656 |
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| author | Christophe Leroy Bruno Pereira Edouard Soum Claire Bachelier Elisabeth Coupez Laure Calvet Konstantinos Bachoumas Claire Dupuis Bertrand Souweine Alexandre Lautrette |
| author_facet | Christophe Leroy Bruno Pereira Edouard Soum Claire Bachelier Elisabeth Coupez Laure Calvet Konstantinos Bachoumas Claire Dupuis Bertrand Souweine Alexandre Lautrette |
| author_sort | Christophe Leroy |
| collection | DOAJ |
| description | Abstract Background Regional citrate anticoagulation (RCA) is the gold standard of anticoagulation for continuous renal replacement therapy but is rarely used for intermittent hemodialysis (IHD) in ICU. Few studies assessed the safety and efficacy of RCA during IHD in ICU; however, no data are available comparing RCA to heparin anticoagulation, which are commonly used for IHD. The aim of this study was to assess the efficacy and safety of RCA compared to heparin anticoagulation during IHD. Methods This retrospective single-center cohort study included consecutive ICU patients treated with either heparin anticoagulation (unfractionated or low-molecular-weight heparin) or RCA for IHD from July to September in 2015 and 2017. RCA was performed with citrate infusion according to blood flow and calcium infusion by diffusive influx from dialysate. Using a propensity score analysis, as the primary endpoint we assessed whether RCA improved efficacy, quantified with Kt/V from the ionic dialysance, compared to heparin anticoagulation. The secondary endpoint was safety. Exploratory analyses were performed on the changes in efficacy and safety between the implementation period (2015) and at long term (2017). Results In total, 208 IHD sessions were performed in 56 patients and were compared (124 RCA and 84 heparin coagulation). There was no difference in Kt/V between RCA and heparin (0.95 ± 0.38 vs. 0.89 ± 0.32; p = 0.98). A higher number of circuit clotting (12.9% vs. 2.4%; p = 0.02) and premature interruption resulting from acute high transmembrane pressure (21% vs. 7%; p = 0.02) occurred in the RCA sessions compared to the heparin sessions. In the propensity score-matching analysis, RCA was associated with an increased risk of circuit clotting (absolute differences = 0.10, 95% CI [0.03–0.18]; p = 0.008). There was no difference in efficacy and safety between the two time periods (2015 and 2017). Conclusion RCA with calcium infusion by diffusive influx from dialysate for IHD was easy to implement with stable long-term efficacy and safety but did not improve efficacy and could be associated with an increased risk of circuit clotting compared to heparin anticoagulation in non-selected ICU patients. Randomized trials to determine the best anticoagulation for IHD in ICU patients should be conducted in a variety of settings. |
| first_indexed | 2024-12-17T08:39:04Z |
| format | Article |
| id | doaj.art-9393263019564dddb62ea7fc4b7e5eca |
| institution | Directory Open Access Journal |
| issn | 2110-5820 |
| language | English |
| last_indexed | 2024-12-17T08:39:04Z |
| publishDate | 2021-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Annals of Intensive Care |
| spelling | doaj.art-9393263019564dddb62ea7fc4b7e5eca2022-12-21T21:56:24ZengSpringerOpenAnnals of Intensive Care2110-58202021-01-011111910.1186/s13613-021-00803-xComparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort studyChristophe Leroy0Bruno Pereira1Edouard Soum2Claire Bachelier3Elisabeth Coupez4Laure Calvet5Konstantinos Bachoumas6Claire Dupuis7Bertrand Souweine8Alexandre Lautrette9Medical Intensive Care Unit, Gabriel-Montpied University HospitalBiostatistics Unit (DRCI), Gabriel-Montpied University HospitalMedical Intensive Care Unit, Gabriel-Montpied University HospitalMedical Intensive Care Unit, Gabriel-Montpied University HospitalMedical Intensive Care Unit, Gabriel-Montpied University HospitalMedical Intensive Care Unit, Gabriel-Montpied University HospitalMedical Intensive Care Unit, Gabriel-Montpied University HospitalMedical Intensive Care Unit, Gabriel-Montpied University HospitalMedical Intensive Care Unit, Gabriel-Montpied University HospitalMedical Intensive Care Unit, Gabriel-Montpied University HospitalAbstract Background Regional citrate anticoagulation (RCA) is the gold standard of anticoagulation for continuous renal replacement therapy but is rarely used for intermittent hemodialysis (IHD) in ICU. Few studies assessed the safety and efficacy of RCA during IHD in ICU; however, no data are available comparing RCA to heparin anticoagulation, which are commonly used for IHD. The aim of this study was to assess the efficacy and safety of RCA compared to heparin anticoagulation during IHD. Methods This retrospective single-center cohort study included consecutive ICU patients treated with either heparin anticoagulation (unfractionated or low-molecular-weight heparin) or RCA for IHD from July to September in 2015 and 2017. RCA was performed with citrate infusion according to blood flow and calcium infusion by diffusive influx from dialysate. Using a propensity score analysis, as the primary endpoint we assessed whether RCA improved efficacy, quantified with Kt/V from the ionic dialysance, compared to heparin anticoagulation. The secondary endpoint was safety. Exploratory analyses were performed on the changes in efficacy and safety between the implementation period (2015) and at long term (2017). Results In total, 208 IHD sessions were performed in 56 patients and were compared (124 RCA and 84 heparin coagulation). There was no difference in Kt/V between RCA and heparin (0.95 ± 0.38 vs. 0.89 ± 0.32; p = 0.98). A higher number of circuit clotting (12.9% vs. 2.4%; p = 0.02) and premature interruption resulting from acute high transmembrane pressure (21% vs. 7%; p = 0.02) occurred in the RCA sessions compared to the heparin sessions. In the propensity score-matching analysis, RCA was associated with an increased risk of circuit clotting (absolute differences = 0.10, 95% CI [0.03–0.18]; p = 0.008). There was no difference in efficacy and safety between the two time periods (2015 and 2017). Conclusion RCA with calcium infusion by diffusive influx from dialysate for IHD was easy to implement with stable long-term efficacy and safety but did not improve efficacy and could be associated with an increased risk of circuit clotting compared to heparin anticoagulation in non-selected ICU patients. Randomized trials to determine the best anticoagulation for IHD in ICU patients should be conducted in a variety of settings.https://doi.org/10.1186/s13613-021-00803-xIntermittent hemodialysisRegional citrate anticoagulationICUHeparin anticoagulationRenal replacement therapy |
| spellingShingle | Christophe Leroy Bruno Pereira Edouard Soum Claire Bachelier Elisabeth Coupez Laure Calvet Konstantinos Bachoumas Claire Dupuis Bertrand Souweine Alexandre Lautrette Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study Annals of Intensive Care Intermittent hemodialysis Regional citrate anticoagulation ICU Heparin anticoagulation Renal replacement therapy |
| title | Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study |
| title_full | Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study |
| title_fullStr | Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study |
| title_full_unstemmed | Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study |
| title_short | Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study |
| title_sort | comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in icu patients a propensity score matched cohort study |
| topic | Intermittent hemodialysis Regional citrate anticoagulation ICU Heparin anticoagulation Renal replacement therapy |
| url | https://doi.org/10.1186/s13613-021-00803-x |
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