Diagnostic challenges in systemic amyloidosis: a case report with clinical and laboratorial pitfalls
Currently, there is growing evidence in the literature warning of misdiagnosis involving amyloidosis and chronic inflammatory demyelinating polyneuropathy (CIDP). Although inducing clinical manifestations outside the peripheral nervous system, light chain and transthyretin amyloidosis may initially...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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University of São Paulo
2021-10-01
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| Series: | Autopsy and Case Reports |
| Subjects: | |
| Online Access: | https://www.revistas.usp.br/autopsy/article/view/191243 |
| _version_ | 1818908484584865792 |
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| author | Angelina Maria Martins Lino Jussara Bianchi Castelli Roberta Shcolnik Szor Fabio Fernandes Vera Demarchi Aiello |
| author_facet | Angelina Maria Martins Lino Jussara Bianchi Castelli Roberta Shcolnik Szor Fabio Fernandes Vera Demarchi Aiello |
| author_sort | Angelina Maria Martins Lino |
| collection | DOAJ |
| description | Currently, there is growing evidence in the literature warning of misdiagnosis involving amyloidosis and chronic inflammatory demyelinating polyneuropathy (CIDP). Although inducing clinical manifestations outside the peripheral nervous system, light chain and transthyretin amyloidosis may initially present with peripheral neuropathy, which can be indistinguishable from CIDP, leading to a delay in the correct diagnosis. Besides, the precise identification of the amyloid subtype is often challenging. This case report exemplifies clinical and laboratory pitfalls in diagnosing amyloidosis and subtyping amyloid, exposing the patient to potentially harmful procedures |
| first_indexed | 2024-12-19T22:11:45Z |
| format | Article |
| id | doaj.art-9393e65cea74450e90766aa05796d76b |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-12-19T22:11:45Z |
| publishDate | 2021-10-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-9393e65cea74450e90766aa05796d76b2022-12-21T20:03:52ZengUniversity of São PauloAutopsy and Case Reports2236-19602021-10-0111Diagnostic challenges in systemic amyloidosis: a case report with clinical and laboratorial pitfallsAngelina Maria Martins Lino0 Jussara Bianchi Castelli1Roberta Shcolnik Szor2Fabio Fernandes3Vera Demarchi Aiello4 Universidade de São Paulo (USP), Hospital das Clínicas, Department of Neurology, Clinical Peripheral Nerve Group, São Paulo, SP, Brasil Universidade de São Paulo (USP), Instituto do Coração, Laboratory of Pathology, São Paulo, SP, Brasil Universidade de São Paulo (USP), Instituto do Câncer do Estado de São Paulo, São Paulo, SP, Brasil Universidade de São Paulo (USP), Instituto do Coração, Cardiomiopathy Group, São Paulo, SP, Brasil Universidade de São Paulo (USP), Instituto do Coração, Laboratory of Pathology, São Paulo, SP, BrasilCurrently, there is growing evidence in the literature warning of misdiagnosis involving amyloidosis and chronic inflammatory demyelinating polyneuropathy (CIDP). Although inducing clinical manifestations outside the peripheral nervous system, light chain and transthyretin amyloidosis may initially present with peripheral neuropathy, which can be indistinguishable from CIDP, leading to a delay in the correct diagnosis. Besides, the precise identification of the amyloid subtype is often challenging. This case report exemplifies clinical and laboratory pitfalls in diagnosing amyloidosis and subtyping amyloid, exposing the patient to potentially harmful procedureshttps://www.revistas.usp.br/autopsy/article/view/191243PolyradiculoneuropathyChronic Inflammatory DemyelinatingDiagnostic ErrorsAmyloidosisFamilialLight Chain Immunoglobulin Amyloidosis |
| spellingShingle | Angelina Maria Martins Lino Jussara Bianchi Castelli Roberta Shcolnik Szor Fabio Fernandes Vera Demarchi Aiello Diagnostic challenges in systemic amyloidosis: a case report with clinical and laboratorial pitfalls Autopsy and Case Reports Polyradiculoneuropathy Chronic Inflammatory Demyelinating Diagnostic Errors Amyloidosis Familial Light Chain Immunoglobulin Amyloidosis |
| title | Diagnostic challenges in systemic amyloidosis: a case report with clinical and laboratorial pitfalls |
| title_full | Diagnostic challenges in systemic amyloidosis: a case report with clinical and laboratorial pitfalls |
| title_fullStr | Diagnostic challenges in systemic amyloidosis: a case report with clinical and laboratorial pitfalls |
| title_full_unstemmed | Diagnostic challenges in systemic amyloidosis: a case report with clinical and laboratorial pitfalls |
| title_short | Diagnostic challenges in systemic amyloidosis: a case report with clinical and laboratorial pitfalls |
| title_sort | diagnostic challenges in systemic amyloidosis a case report with clinical and laboratorial pitfalls |
| topic | Polyradiculoneuropathy Chronic Inflammatory Demyelinating Diagnostic Errors Amyloidosis Familial Light Chain Immunoglobulin Amyloidosis |
| url | https://www.revistas.usp.br/autopsy/article/view/191243 |
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