Risk factors for deep vein thrombosis even using low-molecular-weight heparin after total knee arthroplasty
Abstract Background With an increase in deep vein thrombosis (DVT) following total knee arthroplasty (TKA) in the Asian population, most surgeons today use a form of prophylactic anticoagulant agents in patients after TKA. Nevertheless, DVT occasionally develops even in these patients with prophylax...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Knee Surgery & Related Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43019-021-00109-z |
| _version_ | 1818364163267756032 |
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| author | Joon Kyu Lee Kee Byoung Lee Joong Il Kim Gun Tae Park Young Chang Cho |
| author_facet | Joon Kyu Lee Kee Byoung Lee Joong Il Kim Gun Tae Park Young Chang Cho |
| author_sort | Joon Kyu Lee |
| collection | DOAJ |
| description | Abstract Background With an increase in deep vein thrombosis (DVT) following total knee arthroplasty (TKA) in the Asian population, most surgeons today use a form of prophylactic anticoagulant agents in patients after TKA. Nevertheless, DVT occasionally develops even in these patients with prophylaxis. The purpose of this study was to identify the risk factors for DVT after TKA in cases of postoperative low-molecular-weight heparin (LMWH) use. Methods We designed a retrospective study with 103 patients who underwent primary TKA. From the second postoperative day, 60 mg of LMWH was subcutaneously injected into the patients daily. On the seventh postoperative day, patients had computed tomography angiography to check whether they had DVT. Regarding risk factors, we investigated patients’ gender, age, surgical site (unilateral/bilateral), body mass index, method of anesthesia, preoperative hypertension, diabetes, hypercholesterolemia status, and prothrombin time/international normalized ratio from electronic medical records. We analyzed the statistical significance of these risk factors. Results Statistically significant factors in the single-variable analysis were surgical site (unilateral/bilateral), body mass index, preoperative hypertension status, and anesthesia method. Multiple logistic regression analysis with these factors revealed that the surgical site (unilateral/bilateral, p = 0.024) and anesthesia method (p = 0.039) were significant factors for the occurrence of postoperative DVT after TKA. Conclusions Patients undergoing simultaneous bilateral TKAs and patients undergoing TKA with general anesthesia need more attention regarding DVT even with chemoprophylaxis using LMWH after TKA. |
| first_indexed | 2024-12-13T22:00:00Z |
| format | Article |
| id | doaj.art-93981d198cc843fbaa0b39e643a3bc4b |
| institution | Directory Open Access Journal |
| issn | 2234-2451 |
| language | English |
| last_indexed | 2024-12-13T22:00:00Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Knee Surgery & Related Research |
| spelling | doaj.art-93981d198cc843fbaa0b39e643a3bc4b2022-12-21T23:30:03ZengBMCKnee Surgery & Related Research2234-24512021-09-013311710.1186/s43019-021-00109-zRisk factors for deep vein thrombosis even using low-molecular-weight heparin after total knee arthroplastyJoon Kyu Lee0Kee Byoung Lee1Joong Il Kim2Gun Tae Park3Young Chang Cho4Department of Orthopaedic Surgery, Konkuk University Medical CenterDepartment of Orthopaedic Surgery, Cheongju St. Mary’s HospitalDepartment of Orthopaedic Surgery, Hallym University Kangnam Sacred Heart HospitalDepartment of Orthopaedic Surgery, Hallym University Sacred Heart HospitalDepartment of Orthopaedic Surgery, Konkuk University Medical CenterAbstract Background With an increase in deep vein thrombosis (DVT) following total knee arthroplasty (TKA) in the Asian population, most surgeons today use a form of prophylactic anticoagulant agents in patients after TKA. Nevertheless, DVT occasionally develops even in these patients with prophylaxis. The purpose of this study was to identify the risk factors for DVT after TKA in cases of postoperative low-molecular-weight heparin (LMWH) use. Methods We designed a retrospective study with 103 patients who underwent primary TKA. From the second postoperative day, 60 mg of LMWH was subcutaneously injected into the patients daily. On the seventh postoperative day, patients had computed tomography angiography to check whether they had DVT. Regarding risk factors, we investigated patients’ gender, age, surgical site (unilateral/bilateral), body mass index, method of anesthesia, preoperative hypertension, diabetes, hypercholesterolemia status, and prothrombin time/international normalized ratio from electronic medical records. We analyzed the statistical significance of these risk factors. Results Statistically significant factors in the single-variable analysis were surgical site (unilateral/bilateral), body mass index, preoperative hypertension status, and anesthesia method. Multiple logistic regression analysis with these factors revealed that the surgical site (unilateral/bilateral, p = 0.024) and anesthesia method (p = 0.039) were significant factors for the occurrence of postoperative DVT after TKA. Conclusions Patients undergoing simultaneous bilateral TKAs and patients undergoing TKA with general anesthesia need more attention regarding DVT even with chemoprophylaxis using LMWH after TKA.https://doi.org/10.1186/s43019-021-00109-zDeep vein thrombosisTotal knee arthroplastyAnticoagulant agentLow-molecular-weight-heparinRisk factor |
| spellingShingle | Joon Kyu Lee Kee Byoung Lee Joong Il Kim Gun Tae Park Young Chang Cho Risk factors for deep vein thrombosis even using low-molecular-weight heparin after total knee arthroplasty Knee Surgery & Related Research Deep vein thrombosis Total knee arthroplasty Anticoagulant agent Low-molecular-weight-heparin Risk factor |
| title | Risk factors for deep vein thrombosis even using low-molecular-weight heparin after total knee arthroplasty |
| title_full | Risk factors for deep vein thrombosis even using low-molecular-weight heparin after total knee arthroplasty |
| title_fullStr | Risk factors for deep vein thrombosis even using low-molecular-weight heparin after total knee arthroplasty |
| title_full_unstemmed | Risk factors for deep vein thrombosis even using low-molecular-weight heparin after total knee arthroplasty |
| title_short | Risk factors for deep vein thrombosis even using low-molecular-weight heparin after total knee arthroplasty |
| title_sort | risk factors for deep vein thrombosis even using low molecular weight heparin after total knee arthroplasty |
| topic | Deep vein thrombosis Total knee arthroplasty Anticoagulant agent Low-molecular-weight-heparin Risk factor |
| url | https://doi.org/10.1186/s43019-021-00109-z |
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