The Impact of the <i>FKBP5</i> Gene Polymorphisms on the Relationship between Traumatic Life Events and Psychotic-Like Experiences in Non-Clinical Adults
Common variations of the <i>FKBP5</i> gene are implicated in psychotic disorders, by modulating the hypothalamic–pituitary–adrenal axis reactivity to stress. It has been demonstrated that some of them might moderate the effects of childhood trauma on psychosis proneness. However, these a...
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MDPI AG
2021-04-01
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| author | Filip Stramecki Dorota Frydecka Łukasz Gawęda Katarzyna Prochwicz Joanna Kłosowska Jerzy Samochowiec Krzysztof Szczygieł Edyta Pawlak Elżbieta Szmida Paweł Skiba Andrzej Cechnicki Błażej Misiak |
| author_facet | Filip Stramecki Dorota Frydecka Łukasz Gawęda Katarzyna Prochwicz Joanna Kłosowska Jerzy Samochowiec Krzysztof Szczygieł Edyta Pawlak Elżbieta Szmida Paweł Skiba Andrzej Cechnicki Błażej Misiak |
| author_sort | Filip Stramecki |
| collection | DOAJ |
| description | Common variations of the <i>FKBP5</i> gene are implicated in psychotic disorders, by modulating the hypothalamic–pituitary–adrenal axis reactivity to stress. It has been demonstrated that some of them might moderate the effects of childhood trauma on psychosis proneness. However, these associations have not been investigated with respect to traumatic life events (TLEs). Therefore, we aimed to explore whether the <i>FKBP5</i> polymorphisms moderate the effects of TLEs on the level of psychotic-like experiences (PLEs). A total of 535 non-clinical adults were approached for participation, and genotyping of six <i>FKBP5</i> polymorphisms (rs3800373, rs9470080, rs4713902, rs737054, rs1360780 and rs9296158) was performed. The Prodromal Questionnaire-16 (PQ-16) and the Traumatic Events Checklist (TEC) were administered to assess PLEs and TLEs, respectively. Among the rs1360780 CC homozygotes, a history of physical abuse was associated with significantly higher PQ-16 scores. This difference was not significant in the rs1360780 T allele carriers. Similarly, a history of physical abuse was associated with significantly higher PQ-16 scores in the rs9296158 GG homozygotes but not in the rs9296158 A allele carriers. Finally, emotional neglect was related to significantly higher PQ-16 scores in the rs737054 T allele carriers but not in the rs737054 CC homozygotes. The present study indicates that variation in the <i>FKBP5</i> gene might moderate the effects of lifetime traumatic events on psychosis proneness. |
| first_indexed | 2024-03-10T11:52:15Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T11:52:15Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
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| series | Brain Sciences |
| spelling | doaj.art-9399eb7cf22745948df78d15438a4fed2023-11-21T17:38:23ZengMDPI AGBrain Sciences2076-34252021-04-0111556110.3390/brainsci11050561The Impact of the <i>FKBP5</i> Gene Polymorphisms on the Relationship between Traumatic Life Events and Psychotic-Like Experiences in Non-Clinical AdultsFilip Stramecki0Dorota Frydecka1Łukasz Gawęda2Katarzyna Prochwicz3Joanna Kłosowska4Jerzy Samochowiec5Krzysztof Szczygieł6Edyta Pawlak7Elżbieta Szmida8Paweł Skiba9Andrzej Cechnicki10Błażej Misiak11Department of Psychiatry, Wroclaw Medical University, Pasteur Street 10, 50-367 Wroclaw, PolandDepartment of Psychiatry, Wroclaw Medical University, Pasteur Street 10, 50-367 Wroclaw, PolandClinical Neuroscience Lab, Institute of Psychology, Polish Academy of Sciences, Jaracza Street 1, 00-378 Warsaw, PolandInstitute of Psychology, Jagiellonian University, Ingardena 6 Street, 30-060 Krakow, PolandInstitute of Psychology, Jagiellonian University, Ingardena 6 Street, 30-060 Krakow, PolandDepartment of Psychiatry, Pomeranian Medical University, Broniewskiego 26 Street, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University, Broniewskiego 26 Street, 71-457 Szczecin, PolandDepartment of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla Street 12, 53-114 Wroclaw, PolandDepartment of Genetics, Wroclaw Medical University, Marcinkowskiego 1 Street, 50-368 Wroclaw, PolandDepartment of Genetics, Wroclaw Medical University, Marcinkowskiego 1 Street, 50-368 Wroclaw, PolandDepartment of Community Psychiatry, Medical College Jagiellonian University, Sikorskiego Place 2, 31-115 Krakow, PolandDepartment of Psychiatry, Wroclaw Medical University, Pasteur Street 10, 50-367 Wroclaw, PolandCommon variations of the <i>FKBP5</i> gene are implicated in psychotic disorders, by modulating the hypothalamic–pituitary–adrenal axis reactivity to stress. It has been demonstrated that some of them might moderate the effects of childhood trauma on psychosis proneness. However, these associations have not been investigated with respect to traumatic life events (TLEs). Therefore, we aimed to explore whether the <i>FKBP5</i> polymorphisms moderate the effects of TLEs on the level of psychotic-like experiences (PLEs). A total of 535 non-clinical adults were approached for participation, and genotyping of six <i>FKBP5</i> polymorphisms (rs3800373, rs9470080, rs4713902, rs737054, rs1360780 and rs9296158) was performed. The Prodromal Questionnaire-16 (PQ-16) and the Traumatic Events Checklist (TEC) were administered to assess PLEs and TLEs, respectively. Among the rs1360780 CC homozygotes, a history of physical abuse was associated with significantly higher PQ-16 scores. This difference was not significant in the rs1360780 T allele carriers. Similarly, a history of physical abuse was associated with significantly higher PQ-16 scores in the rs9296158 GG homozygotes but not in the rs9296158 A allele carriers. Finally, emotional neglect was related to significantly higher PQ-16 scores in the rs737054 T allele carriers but not in the rs737054 CC homozygotes. The present study indicates that variation in the <i>FKBP5</i> gene might moderate the effects of lifetime traumatic events on psychosis proneness.https://www.mdpi.com/2076-3425/11/5/561schizophreniageneticscortisolHPA axis |
| spellingShingle | Filip Stramecki Dorota Frydecka Łukasz Gawęda Katarzyna Prochwicz Joanna Kłosowska Jerzy Samochowiec Krzysztof Szczygieł Edyta Pawlak Elżbieta Szmida Paweł Skiba Andrzej Cechnicki Błażej Misiak The Impact of the <i>FKBP5</i> Gene Polymorphisms on the Relationship between Traumatic Life Events and Psychotic-Like Experiences in Non-Clinical Adults Brain Sciences schizophrenia genetics cortisol HPA axis |
| title | The Impact of the <i>FKBP5</i> Gene Polymorphisms on the Relationship between Traumatic Life Events and Psychotic-Like Experiences in Non-Clinical Adults |
| title_full | The Impact of the <i>FKBP5</i> Gene Polymorphisms on the Relationship between Traumatic Life Events and Psychotic-Like Experiences in Non-Clinical Adults |
| title_fullStr | The Impact of the <i>FKBP5</i> Gene Polymorphisms on the Relationship between Traumatic Life Events and Psychotic-Like Experiences in Non-Clinical Adults |
| title_full_unstemmed | The Impact of the <i>FKBP5</i> Gene Polymorphisms on the Relationship between Traumatic Life Events and Psychotic-Like Experiences in Non-Clinical Adults |
| title_short | The Impact of the <i>FKBP5</i> Gene Polymorphisms on the Relationship between Traumatic Life Events and Psychotic-Like Experiences in Non-Clinical Adults |
| title_sort | impact of the i fkbp5 i gene polymorphisms on the relationship between traumatic life events and psychotic like experiences in non clinical adults |
| topic | schizophrenia genetics cortisol HPA axis |
| url | https://www.mdpi.com/2076-3425/11/5/561 |
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