Study of Sodium Valproate's Side Effects in 2 to 15 -Year-Old Children with Epilepsy or Migraine Disorders
Background: Valproic acid is a wide spectrum drug in treatment of different types of epilepsy and migraine disorders. However, few studies have been conducted concerning drug-related side effects and their importance, particularly among Iranian children. Methods: This prospective study was performe...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2016-08-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/6065 |
| _version_ | 1797759604387479552 |
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| author | Omid Yaghini Jafar Nasiri Parisa Nasr-Isfahani |
| author_facet | Omid Yaghini Jafar Nasiri Parisa Nasr-Isfahani |
| author_sort | Omid Yaghini |
| collection | DOAJ |
| description | Background: Valproic acid is a wide spectrum drug in treatment of different types of epilepsy and migraine disorders. However, few studies have been conducted concerning drug-related side effects and their importance, particularly among Iranian children.
Methods: This prospective study was performed on 217 children aged 2 to 15 years old during 2014-15. Simple sampling was used to select children referred to pediatric neurologist in special clinic of medical university of Isfahan, Iran. Required data including demographic data, cause and dose and duration of using sodium valproate and drug-related side effects were collected. One case developed acute pancreatitis and 2 patients passed away.
Findings: Out of 217 subjects, most common complication was weight gain in 112 patients (51.6%). Increasing appetite (31.8%), abdominal pain (16.1%), headache (6.0%) and educational decrease (4.1%) significantly related to increasing age and improving mood state (5.1%) related to decreasing age(P = 0.036). Vomiting (3.2%) and thrombocytopenia (1.8%) related to increasing dose of valproate (respectively, P = 0.0001, P = 0.020). Other complications were not associated with age and drug's dose.
Conclusion: Serious adverse reactions of sodium valproate as an antiepileptic drug is rare but physician should be careful about alarming signs in children to prevent severe complications. |
| first_indexed | 2024-03-12T18:46:50Z |
| format | Article |
| id | doaj.art-939a1dc845ee49c592769508a7456cb3 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T18:46:50Z |
| publishDate | 2016-08-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-939a1dc845ee49c592769508a7456cb32023-08-02T07:37:07ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2016-08-01343877077112260Study of Sodium Valproate's Side Effects in 2 to 15 -Year-Old Children with Epilepsy or Migraine DisordersOmid Yaghini0Jafar Nasiri1Parisa Nasr-Isfahani2Assistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranBackground: Valproic acid is a wide spectrum drug in treatment of different types of epilepsy and migraine disorders. However, few studies have been conducted concerning drug-related side effects and their importance, particularly among Iranian children. Methods: This prospective study was performed on 217 children aged 2 to 15 years old during 2014-15. Simple sampling was used to select children referred to pediatric neurologist in special clinic of medical university of Isfahan, Iran. Required data including demographic data, cause and dose and duration of using sodium valproate and drug-related side effects were collected. One case developed acute pancreatitis and 2 patients passed away. Findings: Out of 217 subjects, most common complication was weight gain in 112 patients (51.6%). Increasing appetite (31.8%), abdominal pain (16.1%), headache (6.0%) and educational decrease (4.1%) significantly related to increasing age and improving mood state (5.1%) related to decreasing age(P = 0.036). Vomiting (3.2%) and thrombocytopenia (1.8%) related to increasing dose of valproate (respectively, P = 0.0001, P = 0.020). Other complications were not associated with age and drug's dose. Conclusion: Serious adverse reactions of sodium valproate as an antiepileptic drug is rare but physician should be careful about alarming signs in children to prevent severe complications.http://jims.mui.ac.ir/index.php/jims/article/view/6065Valproic acidEpilepsyMigraineDrug-related side effectsChild |
| spellingShingle | Omid Yaghini Jafar Nasiri Parisa Nasr-Isfahani Study of Sodium Valproate's Side Effects in 2 to 15 -Year-Old Children with Epilepsy or Migraine Disorders مجله دانشکده پزشکی اصفهان Valproic acid Epilepsy Migraine Drug-related side effects Child |
| title | Study of Sodium Valproate's Side Effects in 2 to 15 -Year-Old Children with Epilepsy or Migraine Disorders |
| title_full | Study of Sodium Valproate's Side Effects in 2 to 15 -Year-Old Children with Epilepsy or Migraine Disorders |
| title_fullStr | Study of Sodium Valproate's Side Effects in 2 to 15 -Year-Old Children with Epilepsy or Migraine Disorders |
| title_full_unstemmed | Study of Sodium Valproate's Side Effects in 2 to 15 -Year-Old Children with Epilepsy or Migraine Disorders |
| title_short | Study of Sodium Valproate's Side Effects in 2 to 15 -Year-Old Children with Epilepsy or Migraine Disorders |
| title_sort | study of sodium valproate s side effects in 2 to 15 year old children with epilepsy or migraine disorders |
| topic | Valproic acid Epilepsy Migraine Drug-related side effects Child |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/6065 |
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